Results 81 to 90 of about 52,035 (209)

Mitochondrial Localization of Cx26 Promotes Colorectal Cancer Malignancy and Exposes a Fatal Vulnerability to Drug Targeting

Advanced Science, EarlyView.
Mitochondrial localization of Cx26 emerges as a double‐edged sword in colorectal cancer. PIMT‐mediated methylation of Cx26 promotes its mitochondrial localization and stability. Mitochondrial Cx26 then facilitates ER‐mitochondria communication and Ca2+ signaling, thereby promoting metastatic progression. Bortezomib exploits this malignant adaptation by
Jie Wang, Lu Chen, Jia Qin, Xiaoning Wang, Sunlan Ye, Ning An, Mei Bai, Yan Shen, Xuefeng Wu, Qiang Xu   +9 more
wiley   +1 more source

Focal adhesion kinase promotes ribosome biogenesis to drive advanced thyroid cancer cell growth and survival

Frontiers in Oncology
IntroductionAdvanced thyroid cancer, including papillary (PTC) and anaplastic thyroid cancer (ATC), are the leading causes of endocrine cancer deaths. Thus, there is a critical need to identify novel therapeutic targets to improve standard of care. Focal
Meghan D. Kellett, Vibha Sharma, Madeline E. Sherlock, Umarani Pugazhenthi, Madison M. Rose, Molishree U. Joshi, Molishree U. Joshi, Monika Dzieciatkowska, Vu Nguyen, Philip Reigan, Kirk C. Hansen, Jeffrey S. Kieft, Rebecca E. Schweppe, Rebecca E. Schweppe   +13 more
doaj   +1 more source

Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549

, 2015
Background: Fangchinoline as a novel anti-tumor agent has been paid attention in several types of cancers cells except lung cancer. Here we have investigated the effect of fangchinoline on A549 cells and its underlying mechanism.Purpose: The purpose of ...
Tingting Zhang (264633), Kaiwen Wang (838527), Xiaoming Li (7401), Bingyu Guo (838525), Jingyuan Su (838526)   +4 more
core   +1 more source

FAK Mediated Coordination of Extracellular Matrix Remodeling and Cellular Mechanics Impairs Nanomedicine Delivery in Solid Tumors

Advanced Science, EarlyView.
FAK orchestrates a mechanical barrier limiting nanomedicine accumulation in solid tumors by coupling ECM remodeling with cytoskeletal tension. Genetic or pharmacological FAK inhibition dismantles this barrier, enhances clathrin‐mediated uptake and penetration, and overcomes delivery limitations to improve antitumor efficacy.
Tian Zhao, Hao Wu, Yujie Qin, Jingfei Zhu, Ye Huang, Wei Chen, Jiaxuan Yu, Xiang Qin, Shun Li, Junjie Li, Tingting Li, Yiyao Liu   +11 more
wiley   +1 more source

Pola dasar pembangunan daerah kabupaten daerah Tingk.II Fak-Fak 1989/1990-1993/1994

, 1989
VI. 69 hlm.
Pemerintah Daerah Tingk.II Fak-fak
core  

Western blot analysis of focal adhesion kinase expression in FAK−/− osteoblasts transiently transfected with the wild-type focal adhesion kinase (WT FAK) construct.

, 2013
Actin was used as a loading control. Expression in FAK−/−, FAK+/+, and MC3T3 osteoblast-like cells is shown as controls. WT FAK protein expression is similar to FAK expression in FAK+/+ and MC3T3 cells.
Kristen L. Lee (306199), Nikitha Reddy Yereddi (306200), Shefali Kumar (306202), W. Joyce Tang (306203), Jennifer T. Blundo (306197), Jae-Beom Kim (25395), Alesha B. Castillo (306196), Eugene Jang (306201), Sarah Zarrin (306204), Julia C. Chen (306198), Christopher R. Jacobs (306205)   +10 more
core   +1 more source

Translational Macrophage Mechano‐Immunotherapy for Next‐Generation Implantable Biomaterials

Advanced NanoBiomed Research, EarlyView.
This review explores how macrophage mechanosensing drives inflammation, fibrosis and foreign body responses to implanted biomaterials. It examines emerging pharmacological strategies to modulate mechanotransduction, alongside biomaterial platforms for localised drug delivery, clinical translation, regulatory considerations and standardised testing ...
Xueying Xu, Ian L. Chin, Richard P. Tan
wiley   +1 more source

Degradation and Dephosphorylation of Focal Adhesion Kinase During Okadaic Acid-Induced Apoptosis in Human Neuroblastoma Cells

Neoplasia: An International Journal for Oncology Research, 2003
Focal adhesion kinase (FAK) prevents apoptosis in many cell types. We have reported that tyrosine residues in FAK are dephosphorylated and FAK is degraded during mannitol-induced apoptosis in human neuroblastoma cells.
Bhumsoo Kim, Cynthia M. van Golen, Eva L. Feldman   +2 more
doaj   +1 more source

Endothelial FAK is required for tumour angiogenesis [PDF]

, 2010
Focal adhesion kinase (FAK) is a cytoplasmic tyrosine kinase that plays a fundamental role in integrin and growth factor mediated signalling and is an important player in cell migration and proliferation, processes vital for angiogenesis.
Parsons, Maddy; id_orcid, Hart, Ian, Vassiliki Kostourou, Fruttiger, Marcus, Louise E. Reynolds, Ian Hart, Shalini Jadeja, Stephen Robinson, Reynolds, Louise E., Koutourou, Vassiliki, Robinson, Stephen, Hodivala-Dilke, Kairbaan M., Holdivala-Dilke, Kairbaan M, Reynolds, Louise.E, Parsons, Maddy, Tavora, Bernardo, Kairbaan M. Hodivala‐Dilke, Robinson, Stephen D., Silvia Batista, Jadeja, Shalini, Maddy Parsons, Batista, Silvia, Bernardo Tavora, Tavore, Bernardo, Kostourou, Vassiliki, Marcus Fruttiger   +25 more
core   +1 more source

Biomimetic Nanomedicine for Aging‐Impaired Bone Regeneration: From Microenvironmental Dysfunction to Precision Therapeutics

Advanced NanoBiomed Research, EarlyView.
Aging disrupts the cellular, immune, vascular, and neural processes required for bone regeneration. This review connects these pathological barriers with biomimetic nanomedicine design, highlighting strategies for cellular rejuvenation, immune modulation, vascular regeneration, and neuro–bone coupling.
Zeyu Wang, He Zhang, Simo Liu, Rui Wang, Yiran Wei, Kailu Zheng, Yanming Guo, Min Li, Dian Yuan, Yuxin Liu, Lifang Feng, Yongping Ma, Yan Liu   +12 more
wiley   +1 more source