Results 121 to 130 of about 219,223 (326)
Advanced Science, EarlyView.Fibrotic scarring persistently challenges urethral reconstruction. This study introduces a conformal, wearable ultrasound bioelectronic system that overcomes this by reprogramming fibroblast fate. The device activates a developmental Wnt–FGF10 axis, driving fibroblasts toward a regenerative FGF10+ phenotype that promotes angiogenesis and matrix ...
Mingming Yu +7 more
wiley +1 more source
FAK expression in neuroblastoma
Journal of Surgical Research, 2003 Abstract Purpose: Focal adhesion kinase (FAK) is an anti-apoptotic protein tyrosine kinase that is over expressed in many human tumors, but it has not been well characterized in neuroblastoma. Previous studies have shown that neuroblastoma cells cultured with VEGF or in coculture with hepatocytes are resistant to apoptotic stimuli.
University of Florida Department of Surgery, Gainesville, FL, USA ( host institution ) +5 more
openaire +2 more sources
Artificial Intelligence for Bone: Theory, Methods, and Applications
Advanced Intelligent Discovery, EarlyView.Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan +3 more
wiley +1 more source
Talin1 Promotes Prostate Cancer Invasion and Metastasis via AKT Signaling and Anoikis Resistance [PDF]
, 2009 Talin1 is an integrin regulatory protein that mediates integrin interactions with the extracellular matrix (ECM). This study investigated the significance of talin1 in prostate cancer progression to metastasis in vitro and in vivo.
Natasha Kyprianou +2 more
core +1 more source
FAK-Mediated Signaling Controls Amyloid Beta Overload, Learning and Memory Deficits in a Mouse Model of Alzheimer’s Disease [PDF]
, 2022 Bisan Saleh +6 more
openalex +1 more source
British Journal of Clinical Pharmacology, EarlyView.With multiple disease‐modifying therapies now available, treatment switching has become an important clinical consideration in the management of spinal muscular atrophy (SMA). While some switches are prompted by suboptimal clinical response, more commonly they are driven by treatment burden, convenience, or adverse events.
Andrej Belančić +4 more
wiley +1 more source
PLoS ONE, 2015 Cancer cell motility is a key phenomenon regulating invasion and metastasis. Focal adhesion kinase (FAK) plays a major role in cellular adhesion and metastasis of various cancers.
Pasupathi Sundaramoorthy +10 more
doaj +1 more source
HMM word-to-phrase alignment with dependency constraints [PDF]
, 2010 In this paper, we extend the HMMwordto-phrase alignment model with syntactic dependency constraints. The syntactic dependencies between multiple words in one language are introduced into the model in a bid to produce coherent alignments.
Ma, Yanjun, Way, Andy
core +1 more source
British Journal of Clinical Pharmacology, EarlyView.Aim Metabolic liver disease, including nonalcoholic fatty liver disease (NAFLD) and nonalcoholic steatohepatitis, is a major cause of chronic liver dysfunction worldwide, creating an urgent need for effective treatments. This systematic literature review (SLR) and network meta‐analysis (NMA) systematically reviews and compares the efficacy and safety ...
Andrej Belančić +8 more
wiley +1 more source