Results 61 to 70 of about 7,761,607 (342)
AAA+ protein unfoldases—the Moirai of the proteome
FEBS Letters, EarlyView.AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley +1 more source
The Dilemma of Falls in Older Persons: Never Forget to Investigate the Syncope
Medicina, 2021 Background and objectives: Falls represent a major cause of morbidity, hospitalizations, and mortality in older persons. The identification of risk conditions for falling is crucial.
Francesca Perego +6 more
doaj +1 more source
Physical activity programs for balance and fall prevention in elderly
Medicine, 2019 Background: Due to demographic changes the world's population is progressively ageing. The physiological decay of the elderly adult may lead to a reduction in the ability to balance and an increased risk of falls becoming an important issue among the ...
E. Thomas +6 more
semanticscholar +1 more source
, 2014 The European Rooms in Miniature, by Mrs. James Ward Thorne, exhibited at John Herron Art Institute contain the depth of reality and the realm of fantasy.
Fall, Carol
core +1 more source
Analyzing Cloud Optical Properties Using Sky Cameras
, 2017 Clouds play a significant role in the fluctuation of solar radiation received by the earth's surface. It is important to study the various cloud properties, as it impacts the total solar irradiance falling on the earth's surface.
Dev, Soumyabrata +3 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Algorithms, 2023 Falls are a major problem in hospitals, and physical or chemical restraints are commonly used to “protect” patients in hospitals and service users in hostels, especially elderly patients with dementia.
Ye-Jiao Mao +4 more
doaj +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source