Results 71 to 80 of about 1,694,002 (297)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
The Influence Of Cereal Share In Crop Rotations On The Grain Yield And Quality Of Winter Wheat
Agriculture, 2015 The aim of our study is to find out the influence of different share of cereals and various fertilisation on the grain yield and quality of winter wheat.
Babulicová Mária, Gavurníková Soňa
doaj +1 more source
Trends In Long-term Unemployment [PDF]
, 2015 Long-term unemployment reached historically high levels following the Great Recession of 2007–2009. Both the number and share of the unemployed who are long-term unemployed typically continue to increase after a recession ends, before falling during a ...
Kosanovich, Karen +1 more
core +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Features of formation, filling and ripening of triticale, wheat, and rye grain
Agrisost, 2020 Context: Triticale (×Triticosecale Wittm.) is a crop valued for food and forage usage. However, excessive precipitation during harvesting cereals, typical for Central regions of Non-Cherozem zone, leads to pre-harvest sprouting and enzyme-mycosis ...
Yuliya Kotenko +3 more
doaj
Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Journal of the Indian Academy of Geriatrics, 2020 Objective: This study aimed to report the fear of falling and assess its associations with several fall-related characteristics and functional fitness parameters among older adults living in the rest home. Methods: Seventy-eight older adults aged between
H Tuna +3 more
doaj +1 more source
Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer
Molecular Oncology, EarlyView.PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta +10 more
wiley +1 more source
Food and Energy SecurityModern agriculture is a complex system that demands real‐time and large‐scale quantification of trait values for evidence‐based decisions. However, high‐profile traits determining market values often lack high‐throughput phenotyping technologies to ...
Bosen Zhang +10 more
doaj +1 more source