Results 1 to 10 of about 52,688 (314)

Metformin Ameliorates Cognitive Deficits and Neuroinflammation in a Mouse Model of Familial Hypercholesterolemia. [PDF]

Neurochem Res
do Nascimento NB, Farias HR, Schons T, Padilha APZ, Costa MV, Peres AM, da Silva LDS, Dantas RM, Ramos JMO, Rodrigues MS, Telles F, Guma FTCR, Moreira JCF, Bast RKSS, de Bem AF, de Oliveira J.   +15 more
europepmc   +3 more sources

Life Course Approach for Managing Familial Hypercholesterolemia [PDF]

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Treatment of familial hypercholesterolemia is directed toward the moment of the medical encounter. However, risk for heart disease as a consequence of having familial hypercholesterolemia is related to lifelong exposure to elevated low‐density ...
Samuel S. Gidding, Dirk J. Blom, Brian McCrindle, Uma Ramaswami, Raul D. Santos, Gerald F. Watts, Albert Wiegman   +6 more
doaj   +2 more sources

Thirty percent of children and young adults with familial hypercholesterolemia treated with statins have adherence issues

American Journal of Preventive Cardiology, 2021
Objective: To assess adherence to lipid lowering therapy (LLT), reasons for poor adherence, and achievement of LDL-C treatment goals in children and young adults with familial hypercholesterolemia (FH).
Gisle Langslet, Anja K. Johansen, Martin P. Bogsrud, Ingunn Narverud, Hilde Risstad, Kjetil Retterstøl, Kirsten B. Holven   +6 more
doaj   +1 more source

Web-Based Tool (FH Family Share) to Increase Uptake of Cascade Testing for Familial Hypercholesterolemia: Development and Evaluation

JMIR Human Factors, 2022
BackgroundFamilial hypercholesterolemia, a prevalent genetic disorder, remains significantly underdiagnosed in the United States.
Hana Bangash, Ahmed Makkawy, Justin H Gundelach, Alexandra A Miller, Kimberly A Jacobson, Iftikhar J Kullo   +5 more
doaj   +1 more source

Effectiveness and safety of PCSK9 inhibitor therapy in patients with familial hypercholesterolemia within a therapeutic program in Poland: Preliminary multicenter data

Cardiology Journal, 2022
BACKGROUND: In Poland, treatment with proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors has become available free of charge in a therapeutic program. Assessed herein, is the efficacy and safety of alirocumab and evolocumab in patients with
Krzysztof Chlebus, Barbara Cybulska, Piotr Dobrowolski, Marzena Romanowska-Kocejko, Marta Żarczyńska-Buchowiecka, Natasza Gilis-Malinowska, Aneta Stróżyk, Justyna Borowiec-Wolna, Marcin Pajkowski, Beata Bobrowska, Renata Rajtar-Salwa, Aleksandra Kwapiszewska, Małgorzata Waluś-Miarka, Magdalena Chmara, Rafał Gałąska, Maciej Małecki, Tomasz Zdrojewski, Marcin Gruchała   +17 more
doaj   +1 more source

Young women with familial hypercholesterolemia have higher LDL-cholesterol burden than men: Novel data using repeated measurements during 12-years follow-up

Atherosclerosis Plus, 2023
Background and aims: The concentration and the duration of exposure to low-density lipoprotein cholesterol (LDL-C) (LDL-C burden) is an important determinant of risk for cardiovascular disease and thresholds has recently been estimated.
Anja K. Johansen, Martin P. Bogsrud, Jacob J. Christensen, Amanda Rundblad, Ingunn Narverud, Stine Ulven, Gisle Langslet, Kjetil Retterstøl, Kirsten B. Holven   +8 more
doaj   +1 more source

A comprehensive metabolic profiling of the metabolically healthy obesity phenotype

Lipids in Health and Disease, 2020
Background The ever-increasing prevalence of obesity constitutes a major health problem worldwide. A subgroup of obese individuals has been described as “metabolically healthy obese” (MHO).
Vibeke H. Telle-Hansen, Jacob J. Christensen, Gulla Aase Formo, Kirsten B. Holven, Stine M. Ulven   +4 more
doaj   +1 more source

The effects of cholesterol accumulation on Achilles tendon biomechanics: A cross-sectional study.

PLoS ONE, 2021
Familial hypercholesterolemia, a common genetic metabolic disorder characterized by high cholesterol levels, is involved in the development of atherosclerosis and other preventable diseases.
Kipling Squier, Alexander Scott, Michael A Hunt, Liam R Brunham, David R Wilson, Hazel Screen, Charlie M Waugh   +6 more
doaj   +1 more source

Familial Hypercholesterolemia

罕见病研究, 2023
Familial hypercholesterolemia (FH) is a group of autosomal co-dominant genetic diseases mainly characterized by abnormal low-density lipoprotein related metabolism.
FENG Siqin, TANG Muyun, WU Wei, ZHANG Shuyang   +3 more
doaj   +1 more source

Searching for new genes associated with the familial hypercholesterolemia phenotype using whole-genome sequencing and machine learning

Вавиловский журнал генетики и селекции, 2023
One of the most common congenital metabolic disorders is familial hypercholesterolemia. Familial hyper-cholesterolemia is a condition caused by a type of genetic defect leading to a decreased rate of removal of low-density lipoproteins from the ...
D. E. Ivanoshchuk, A. B. Kolker, O. V. Timoshchenko, S. E. Semaev, E. V. Shakhtshneider   +4 more
doaj   +1 more source