Results 41 to 50 of about 52,688 (314)

Potent Liver‐Tropic mRNA Lipid Nanoparticles: ApoE‐Mediated Delivery Through a Low‐Density Lipoprotein Receptor Independent Uptake Mechanism

Advanced Materials, EarlyView.
Helper and ionizable lipids play a crucial role in determining ApoE binding and subsequent liver tropism and LDLR‐mediated uptake. Ionizable lipids primarily govern the LDLR‐independent uptake pathway. This complementary interplay between lipid components ultimately governs LNP delivery performance and therapeutic efficacy in the liver.
Ashish Sarode, Christian Ortiz, Tadeh Derstepanian, Natalia Vargas‐Montoya, Priyal Patel, Nikita Khadse, Saikat Manna, Ryan Landis, Joseph Skaleski, Lianne Boeglin, Hongfeng Deng, Anusha Dias, Hong Wang, Debora Barreiros Petropolis, Barak Yahalom, Shrirang Karve, Frank DeRosa   +16 more
wiley   +1 more source

Clinically Actionable Hypercholesterolemia and Hypertriglyceridemia in Children with Nonalcoholic Fatty Liver Disease [PDF]

, 2018
OBJECTIVE: To determine the percentage of children with nonalcoholic fatty liver disease (NAFLD) in whom intervention for low-density lipoprotein cholesterol or triglycerides was indicated based on National Heart, Lung, and Blood Institute guidelines.
Adina Alazraki, Ajay K. Jain, Alan Wells, Albert Hernandez, Alex Towbin, Ali Mencin, Alice Sternberg, Ann Klipsch, Ann Scheimann, April Carr, Averell Sherker, Bradley Aouizerat, Camille Langlois, Claude Sirlin, Craig Bross, Cynthia A. Behling, Cynthia Rigsby, Daniel Podberesky, David E. Kleiner, Debra King, Diana Lopez-Graham, Edward C. Doo, Elena Reynoso, Elizabeth M. Brunt, Emily Ragozzino, Emily Rothbaum Perito, Erin Hallinan, Evelyn Hsu, Gerald Behr, Girish Subbarao, Hannah Awai, James Tonascia, Janet Freebersyser, Janis Durelle, Jay H. Hoofnagle, Jay H. Lefkowitch, Jean P. Molleston, Jeanne M. Clark, Jeffrey B. Schwimmer, Jennifer Collins, Jesse Courtier, Jessica Cruz Munos, Jinping Lai, Joan Siegner, Joel E. Lavine, Jonathan A. Africa, Jose Derdoy, Joy Ito, Kara Cooper, Karen Murray, Katherine Yates, Kathleen Lake, Kathryn E. Harlow, Kathryn Fowler, Kevin P. May, Kim Cecil, Kimberlee Bernstein, Kimberly Kafka, Kimberly P. Newton, Kristin Bramlage, Kristina Wriston, Kumar Sandrasegaran, Laura Miriel, Laura Walker, Laura Wilson, Leanel Maldonado, Linda D. Ferrell, Lisa Sharda, Lixin Zhu, Maria Cordero, Mariana Dominguez Villarreal, Mark H. Fishbein, Mark Van Natta, Matthew Yeh, Melissa Paiz, Melissa Young, Michael Middleton, Michele Donithan, Milana Isaacson, Miriam B. Vos, Molly Bozic, Natasha Feier, Nicholas Raviele, Oscar W. Cummings, Pat Osmack, Patricia H. Belt, Patricia R. Robuck, Patricia Ugalde-Nicalo, Patrika Tsai, Peter F. Whitington, Philip Rosenthal, Rajesh Krisnamurthy, Randolph Otto, Rebecca Cleeton, Rebecca Torrance, Rohit Kohli, Rory Mahabir, Ryan Gill, Ryan Himes, Saeed Mohammad, Sarah Barlow, Sarah Barlow, Saul Karpen, Sherry Brown, Simon Horslen, Sonja Williams, Stavra A. Xanthakos, Stephanie DeVore, Stephanie H. Abrams, Susan S. Baker, Susan Stewart, Susan Torretta, Theresa Cattoor   +112 more
core   +2 more sources

Construction of a Multitissue Cell Atlas Reveals Cell‐Type‐Specific Regulation of Molecular and Complex Phenotypes in Pigs

Advanced Science, EarlyView.
This research conducts an in‐depth investigation of cell‐type‐specific regulatory mechanisms underlying molecular and complex phenotypes through integrative analysis of multitissue single‐nucleus RNA sequencing, bulk RNA‐seq, and genome‐wide association study (GWAS) data in pigs.
Lijuan Chen, Houcheng Li, Jinyan Teng, Zhen Wang, Xiaolu Qu, Zhe Chen, Xiaodian Cai, Haonan Zeng, Zhonghao Bai, Jinghui Li, Xiangchun Pan, Leyan Yan, Fei Wang, Lin Lin, Yonglun Luo, Goutam Sahana, Mogens Sandø Lund, Maria Ballester, Daniel Crespo‐Piazuelo, Peter Karlskov‐Mortensen, Merete Fredholm, Alex Clop, Marcel Amills, Crystal Loving, Christopher K. Tuggle, Ole Madsen, Jiaqi Li, Zhe Zhang, George E. Liu, Jicai Jiang, Lingzhao Fang, Guoqiang Yi   +31 more
wiley   +1 more source

Increased Blood Flow and Tendon Swelling Precedes Vascular Expansion and Tissue Matrix Changes In Early Human Tendinopathy: A Potential Window for Superior Treatment Response

Advanced Science, EarlyView.
Human participants with early‐ or chronic‐stage tendinopathy and healthy controls are investigated using ultrasound Doppler, 3T and 7T MRI, and tendon biopsies. Tendon swelling and hyperperfusion are evident early, while vascular growth and extracellular matrix changes are most pronounced in chronic tendinopathy. Early intervention may provide superior
Max F. R. Merkel, Nikolaj M. Malmgaard‐Clausen, Marius Lendal, Hartwig R. Siebner, René B. Svensson, Stephanie G. Dakin, Marcus Krüger, Luisa Schmidt, Jakob Agergaard, Ching‐Yan Chloé Yeung, S. Peter Magnusson, Michael Kjaer   +11 more
wiley   +1 more source

Assessing the effect of statins in lowering the risk of stroke and preventing cerebral ischemia in patients with hypercholesterolemia [PDF]

, 2017
Numerous analyses have explored the role of statins in reducing stroke incidence, reducing cerebral ischemia in hypercholesterolemic patients, and preventing ischemic stroke.
AlSulaiman, Wafa
core  

Metabolomic study of the LDL receptor null mouse fed a high-fat diet reveals profound perturbations in choline metabolism that are shared with ApoE null mice [PDF]

, 2010
Failure to express or expression of dysfunctional low-density lipoprotein receptors (LDLR) causes familial hypercholesterolemia in humans, a disease characterized by elevated blood cholesterol concentrations, xanthomas, and coronary heart disease ...
Benson, G. Martin, C. Connor, Susan, C. Grimsditch, David, G. Reid, David, Kian Kai, Cheng, L. Griffin, Julian   +5 more
core   +1 more source

Label‐Free Leukocyte Biophysical Profiling Using Impedance‐Deformability Cytometry for Rapid Cardiovascular Risk Stratification

Advanced Science, EarlyView.
This study presents an impedance‐based single‐cell profiling platform that quantifies the electrical and mechanical properties of neutrophils across in vitro, in vivo, and clinical samples. The approach reveals distinct biophysical alterations associated with type 2 diabetes (T2DM) and cardiovascular complications, suggesting its potential utility for ...
Linwei He, Hui Min Tay, Feng Chen, Hong Sheng Cheng, Liang De Wang, Qiqi Nam, Arunachalam Thannirmalai, Lingyan Gong, Aram J. Chung, Nguan Soon Tan, King Ho Holden Li, Rinkoo Dalan, Siu Ling Wong, Han Wei Hou   +13 more
wiley   +1 more source

Familial hypercholesterolemia

Indian Heart Journal
Familial hypercholesterolemia is a common genetic disorder of autosomal inheritance associated with elevated LDL-cholesterol. It is estimated to affect 1:250 individuals in general population roughly estimated to be 5 million in India.
J.P.S. Sawhney, Kushal Madan
doaj   +1 more source

Prevalence of familial hypercholesterolemia in patients with acute coronary syndrome [PDF]

Medicinski Glasnik
Aim To investigate the prevalence of familial hypercholesterolemia in patients with acute coronary syndrome (ACS). Methods The study included fifteen patients with first or repeated ACS and treated/nontreated dyslipidaemia admitted to the Department of ...
Željka Dragila, Matea Lozert, Silvija Canecki-Varžić, Kristina Selthofer-Relatić   +3 more
doaj   +1 more source

Prevalence and pharmacologic management of familial hypercholesterolemia in an unselected contemporary cohort of patients with stable coronary artery disease [PDF]

, 2018
INTRODUCTION: Familial hypercholesterolemia (FH) is an inherited disorder characterized by elevated plasma levels of low-density lipoprotein cholesterol (LDL-C) associated with premature cardiovascular disease. METHODS: Using the data from the START
A., Gulizia, Arca, M., Bosco, B., Callerame, M., Colivicchi, F., De Luca, L, Di, Lenarda, Gonzini, L., Lettica, G. V., Lucci, D., Temporelli, P. L.   +10 more
core   +1 more source