Results 61 to 70 of about 340,370 (339)

Evinacumab for Homozygous Familial Hypercholesterolemia.

New England Journal of Medicine, 2020
BACKGROUND Homozygous familial hypercholesterolemia is characterized by premature cardiovascular disease caused by markedly elevated levels of low-density lipoprotein (LDL) cholesterol.
F. Raal, R. Rosenson, L. Reeskamp, G. Hovingh, John P. Kastelein, P. Rubba, Shazia Ali, P. Banerjee, Kuo-Chen Chan, D. Gipe, N. Khilla, R. Pordy, D. Weinreich, G. Yancopoulos, Yi Zhang, D. Gaudet   +15 more
semanticscholar   +1 more source

Universal screening for familial hypercholesterolemia in 2 populations.

Genetics in Medicine, 2022
PURPOSE In Europe, >2 million individuals with familial hypercholesterolemia (FH) are currently undiagnosed. Effective screening strategies for FH diagnosis in childhood are urgently needed.
U. Šuštar, O. Kordonouri, M. Mlinarič, J. Kovač, S. Arens, K. Sedej, B. Jenko Bizjan, K. Trebušak Podkrajšek, T. Danne, T. Battelino, U. Grošelj   +10 more
semanticscholar   +1 more source

Targeted genetic testing for familial hypercholesterolaemia using next generation sequencing:a population-based study [PDF]

, 2014
BACKGROUND: Familial hypercholesterolaemia (FH) is a common Mendelian condition which, untreated, results in premature coronary heart disease. An estimated 88% of FH cases are undiagnosed in the UK.
Soutar, Anne K., Shona M Kerr, Jennifer Biggs, Anne K Soutar, Aitman, Timothy J., Porteous, David J, Morris, Andrew D., Morris, Andrew D, Scotland, Generation, Blair H Smith, Generation Scotland, Smith, Blair H, Anna F Dominiczak, Thomas, Ellen, Soutar, Anne K, Vandrovcova, Jana, Kerr, Shona M, Kerr, Shona M., Archie Campbell, Biggs, Jennifer, Norsworthy, Penny J, David J Porteous, Laurence Game, Thomas, Ellen R. A., Game, Laurence, Penny J Norsworthy, Smith, Blair H., Norsworthy, Penny J., Campbell, Archie, Porteous, David J., Aitman, Timothy J, Ellen RA Thomas, Dominiczak, Anna F, Smith, Blair H.; id_orcid, Jana Vandrovcova, ?, ?, Dominiczak, Anna F., Thomas, Ellen RA, Timothy J Aitman, Andrew D Morris   +39 more
core   +1 more source

Phase Ib study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis

Hepatology, EarlyView., 2022
Phase 1b study of anlotinib combined with TQB2450 in pretreated advanced biliary tract cancer and biomarker analysis. Abstract Background and Aims We evaluated the efficacy and safety of the antiangiogenic tyrosine kinase inhibitor anlotinib plus TQB2450, a programmed death‐ligand 1 inhibitor in pretreated advanced biliary tract cancers (BTCs ...
Jun Zhou, Yongkun Sun, Wen Zhang, Jiajia Yuan, Zhi Peng, Wei Wang, Jifang Gong, Lin Yang, Yanshuo Cao, Hong Zhao, Chao Chen, Weifeng Wang, Lin Shen, Aiping Zhou   +13 more
wiley   +1 more source

Treatment and follow-up of coronary artery disease in a child with homozygous familial hypercholesterolemia

Medicine Science, 2022
Familial hypercholesterolemia is a metabolic disease caused by a mutation in the low-density lipoprotein receptor gene. It carries early atherosclerosis and coronary artery disease risks.
Mehmet Oncul, Cemsit Karakurt, Ozlem Elkiran, Aysehan Akinci, Nevzat Erdil   +4 more
doaj   +1 more source

Worldwide Prevalence of Familial Hypercholesterolemia: Meta-Analyses of 11 Million Subjects.

Journal of the American College of Cardiology, 2020
BACKGROUND Despite the greater prevalence of familial hypercholesterolemia (FH) in subjects with ischemic heart disease (IHD), premature IHD, and severe hypercholesterolemia (low-density lipoprotein ≥190 mg/dl), overall prevalence estimates are not ...
Sabina O. Beheshti, C. M. Madsen, A. Varbo, B. Nordestgaard   +3 more
semanticscholar   +1 more source

The LDLR, APOB, and PCSK9 Variants of Index Patients with Familial Hypercholesterolemia in Russia

Genes, 2021
Familial hypercholesterolemia (FH) is a common autosomal codominant disorder, characterized by elevated low-density lipoprotein cholesterol levels causing premature atherosclerotic cardiovascular disease.
A. Meshkov, Alexandra Ershova, A. Kiseleva, E. Zotova, E. Sotnikova, A. Petukhova, A. Zharikova, P. Malyshev, T. Rozhkova, A. Blokhina, A. Limonova, V. Ramensky, M. Divashuk, Z. Khasanova, A. Bukaeva, O. Kurilova, O. Skirko, M. Pokrovskaya, V. Mikova, E. Snigir, A. Akinshina, S. Mitrofanov, Daria Kashtanova, V. Makarov, V. Kukharchuk, S. Boytsov, S. Yudin, O. Drapkina   +27 more
semanticscholar   +1 more source

Evaluation of the Frequency of Familial Hypercholesterolemia: A Single-Center Experience

Endocrinology Research and Practice, 2019
Objective: Familial hypercholesterolemia is an autosomal dominant disease associated with elevated low-density lipoprotein cholesterol and increased premature atherosclerosis.
Mehmet Ali EREN, Ataman GÖNEL, İsmail KOYUNCU, Ahmet Cebeli GÖKAY, Tevfik SABUNCU   +4 more
doaj   +1 more source

Familial hypercholesterolemia: Clarifications [PDF]

Cleveland Clinic Journal of Medicine, 2020
To the Editor : The article by Shah and colleagues[1][1] is an excellent review of familial hypercholesterolemia (FH) and highlights an underdiagnosed condition on which clinicians can make a significant impact.
openaire   +2 more sources

Familial Hypercholesterolemia: JACC Focus Seminar 4/4.

Journal of the American College of Cardiology, 2021
Detecting familial hypercholesterolemia (FH) early and "normalizing" low-density lipoprotein (LDL) cholesterol values are the 2 pillars for effective cardiovascular disease prevention in FH.
J. Brandts, K. Ray
semanticscholar   +1 more source