Results 81 to 90 of about 53,176 (324)

Causal Effects of Hydrophilic Bile Acids on Carfilzomib‐Related Cardiovascular Events in Multiple Myeloma: A Mendelian Randomization Study

Clinical Pharmacology &Therapeutics, EarlyView.
Carfilzomib is highly effective in the treatment of multiple myeloma, but it has been associated with cardiovascular adverse events that impact patient outcomes. Our prior global metabolomic analyses indicated an association between hydrophilic bile acids and carfilzomib‐cardiotoxicity risk, although a causal relationship remained to be determined ...
Samia Shabnaz, Eric Farber‐Eger, Marwa Tantawy, Neyousha Shahisavandi, Timothy J. Garrett, Samuel M. Rubinstein, Michael G. Fradley, Mohammed E. Alomar, Danny DeAvila, Kenneth H Shain, R. Frank Cornell, Daniel Lenihan, Qing Lu, Quinn S Wells, Rachid C. Baz, Yan Gong   +15 more
wiley   +1 more source

Prevalence and pharmacologic management of familial hypercholesterolemia in an unselected contemporary cohort of patients with stable coronary artery disease [PDF]

, 2018
INTRODUCTION: Familial hypercholesterolemia (FH) is an inherited disorder characterized by elevated plasma levels of low-density lipoprotein cholesterol (LDL-C) associated with premature cardiovascular disease. METHODS: Using the data from the START
A., Gulizia, Arca, M., Bosco, B., Callerame, M., Colivicchi, F., De Luca, L, Di, Lenarda, Gonzini, L., Lettica, G. V., Lucci, D., Temporelli, P. L.   +10 more
core   +1 more source

SPARCL1 and NT‐proBNP as biomarkers of right ventricular‐to‐pulmonary artery uncoupling in pulmonary hypertension

ESC Heart Failure, Volume 12, Issue 2, Page 1416-1426, April 2025.
Abstract Aims SPARCL1 was recently identified as a biomarker of right ventricular (RV) maladaptation in patients with pulmonary hypertension (PH), and N‐terminal pro‐brain natriuretic protein (NT‐proBNP) is an established biomarker of RV failure in PH. The present study investigated whether NT‐proBNP and SPARCL1 concentrations are associated with load ...
Oliver Dörr, Stanislav Keranov, Paulina van Wickern, Holger Nef, Christian Hamm, Pascal Bauer, Christian Troidl, Samuel Sossalla, Sandra Voss, Christoph Liebetrau, Manuel J. Richter, Henning Gall, Werner Seeger, Ardeschir Ghofrani, Athiththan Yogeswaran, Khodr Tello   +15 more
wiley   +1 more source

Familial hypercholesterolemia supravalvular aortic stenosis and extensive atherosclerosis

Indian Heart Journal, 2018
Familial hypercholesterolemia is an autosomally dominant disorder caused by various mutations in low-density lipoprotein receptor genes. This can lead to premature coronary atherosclerosis and cardiac-related death.
Rajpal Prajapati, Vikas Agrawal
doaj   +1 more source

Familial hypercholesterolemia: current status of the problem, treatment, and prevention

Кардиоваскулярная терапия и профилактика, 2020
Familial hypercholesterolemia is the most common hereditary disease characterized by an increase in low density lipoprotein cholesterol levels and the premature development of atherosclerosis-related cardiovascular diseases.
S. A. Bliznyuk, M. G. Bubnova, M. V. Ezhov   +2 more
doaj   +1 more source

Portuguese Familial Hypercholesterolemia Study: presentation of the study and preliminary results [PDF]

, 2006
Familial hypercholesterolemia (FH) is an autosomal dominant genetic disorder caused, in the majority of cases, by a partial or total lack of functional low density lipoprotein receptors (LDLR).
Bourbon, M., Investigadores do Estudo Português de Hipercolesterolemia Familiar, Rato, Q.   +2 more
core  

Homozygous familial hypercholesterolaemia: new insights and guidance for clinicians to improve detection and clinical management. A position paper from the Consensus Panel on Familial Hypercholesterolaemia of the European Atherosclerosis Society [PDF]

, 2014
AIMS: Homozygous familial hypercholesterolaemia (HoFH) is a rare life-threatening condition characterized by markedly elevated circulating levels of low-density lipoprotein cholesterol (LDL-C) and accelerated, premature atherosclerotic cardiovascular ...
Averna, M, AVERNA, Maurizio, Boileau, C, Boileau, C, Boren, J, Boren, J, Bruckert, E, Bruckert, E, Catapano, A, Catapano, A, Chapman, M, Chapman, M, Chapman, M, Cuchel, M, Cuchel, M, Defesche, J, Defesche, J, Descamps, O, Descamps, O, Ginsberg, H, Ginsberg, H, Ginsberg, H, Hegele, R, Hegele, R, Hovingh, G, Hovingh, G, Humphries, S, Humphries, S, Kovanen, P, Kovanen, P, Kuivenhoven, J, Kuivenhoven, J, Masana, L, Masana, L, Nordestgaard, B, Nordestgaard, B, Pajukanta, P, Pajukanta, P, Parhofer, K, Parhofer, K, Raal, F, Raal, F, Ray, K, Ray, K, Santos, R, Santos, R, Stalenhoef, A, Stalenhoef, A, Steinhagen Thiessen, E, Steinhagen Thiessen, E, Stroes, E, Stroes, E, Taskinen, M, Taskinen, M, Tybjaerg Hansen, A, Tybjaerg Hansen, A, Watts, G, Watts, G, Wiegman, A, Wiegman, A, Wiklund, O, Wiklund, O.   +61 more
core   +1 more source

Cardiovascular toxicity induced by TKIs in patients with chronic myeloid leukaemia: Are women and men different?

ESC Heart Failure, Volume 12, Issue 2, Page 1447-1454, April 2025.
This study analyzes 148 patients (66 women and 82 men) with chronic myeloid leukemia treated with tyrosine kinase inhibitors, focusing on cardiovascular adverse events. The risk assessment, performed using the HFA/ICOS score, reveals sex‐specific differences: venous thrombosis is more common in women, while arterial thrombosis predominates in men.
Cristina Madaudo, Daniela Di Lisi, Antonio Cannatà, Federica Manfrè, Celeste Vullo, Marco Santoro, Ciro Botta, Salvatrice Mancuso, Sergio Siragusa, Alfredo Ruggero Galassi, Giuseppina Novo   +10 more
wiley   +1 more source

Prevalence of Severe Hypercholesterolemia and Familial Hypercholesterolemia Phenotype in Patients with Acute Coronary Syndrome

Medicina
Background and Objectives: Atherosclerotic cardiovascular disease is one of the most common causes of death and disability around the world. Hypercholesterolemia is an established and widely prevalent risk factor; however, the prevalence of severe ...
Urtė Aliošaitienė, Aleksandras Laucevičius, Urtė Smailytė, Egidija Rinkūnienė, Roma Puronaitė, Jūratė Barysienė, Žaneta Petrulionienė   +6 more
doaj   +1 more source

Serum NfL, GFAP, and p‐tau217 in adults with drug‐resistant epilepsy and intellectual disabilities: Signs of ongoing neural injury

Epilepsia, EarlyView.
Abstract Objective Adults with epilepsy and intellectual disabilities (IDs) may be at increased risk of dementia, but clinical evaluation is complex and use of conventional biomarkers is often considered too invasive. We explored abnormality of serum neurofilament light chain (NfL), glial fibrillary acidic protein (GFAP), and phosphorylated tau‐217 (p ...
Hadassa Kwetsie, Inge M. W. Verberk, Jans S. van Ool, Anneke J. J. Rampen, Rebecca Z. Rousset, Nicole I. Wolf, Dederieke A. M. Maes‐Festen, Clara D. M. van Karnebeek, Charlotte E. Teunissen, Erik Boot, Agnies M. van Eeghen   +10 more
wiley   +1 more source