Results 111 to 120 of about 92,750,489 (255)

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Context-specific stressors, work-related social support and work-family conflict : a mediation study [PDF]

, 2013
Understanding the antecedents of work-family conflict is important as it allows organisations to effectively engage in work design for professional employees.
Teo, Stephen, Newton, Cameron J., Soewanto, Karina   +2 more
core  

Unique circulating miRNAome signatures captured with distinct molecular states in Lynch syndrome and sporadic colorectal cancer

Molecular Oncology, EarlyView.
Circulating microRNA profiles distinguish nonmalignant Lynch syndrome from cancer‐associated Lynch syndrome, sporadic colorectal cancer, and healthy controls. Age‐stratified analysis reveals disease‐specific regulatory states, and a six‐miRNA panel shows concordant separation in an independent colorectal tissue cohort.
Ramadhani Salum Chambuso, Md Shohel Ul Islam, Rosa M Xicola, Raj Ramesar, Xavier Llor, Sinclair Steele   +5 more
wiley   +1 more source

How Guilt Drives Emotional Exhaustion in Work–Pet Family Conflict

Animals
Work–pet family conflict has emerged as a novel form of work–life conflict, reflecting the increasingly significant role that pets play in modern families.
Ana Junça-Silva
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

The Silent Threat in Women’s Health: Work and Family Conflict

Women's Health Reports
Aim: This study aimed to examine the level of work–family conflict and the factors affecting it among women academic and administrative staff working at the university. Materials and Methods: The study is descriptive and cross-sectional.
Sevil Cıcek Ozdemır, Selmin Senol
doaj   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Inter-Role Conflict Cycle: Family Distress in Work–Family Dynamics with Job and Home Demands

This study examined the longitudinal relationship between work–family conflict (WFC) and family–work conflict (FWC), with a focus on the moderating role of job demands and home demands, and the mediating role of family distress within dyads (i.e., actor [
Idris, Mohd Awang, Ratnaningsih, Ika Zenita   +1 more
core   +1 more source

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers

Molecular Oncology, EarlyView.
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
Marion David, Arthur Karaulic, Audrey Bennetot, Clémence Fournier, Quentin Odet, Arthur Gouraud, Isabelle Bourget, Cédric Gaggioli, Sandy Giuliano, Frédéric Luciano, Olivier Léger, Zaki Sellam, Gilles Pagès   +12 more
wiley   +1 more source

Relationship between Work-Family Conflict and Intention to leave among Nurses

نشریه پرستاری ایران, 2014
Background & Aim: Nowadays hospitals bear with the financial and human costs because of nurses’ turnover. Many factors affect nurses’ turnover and work-family conflict is one of these variables.
F Sharifzadeh, A Mohammadi Mahmouei, H Alizadeh, S Khani Pordanjani, F Heshmati   +4 more
doaj