Results 81 to 90 of about 16,465,093 (249)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Transformational leadership strengthens work-family balance through interactional justice and trust in the police context

Discover Psychology
This study explores how Transformational Leadership (TFL) is related to work-family interaction—that is, the presence of work-family conflict (WFC) and work-family Enrichment (WFE)—within the Colombian Police, considering the mediating roles of ...
Iván D. Sánchez, Nathalie Peña-García, Mauricio Losada-Otálora   +2 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Examining the mediating role of self-efficacy in the relationship between perceived organizational support and work–family enrichment.

, 2022
Although some organizations have formally introduced flexible work arrangements (FWAs) to enhance work–family enrichment, research indicates that informal organizational characteristics, such as perceived organizational support (POS) to utilize FWAs, may
Siu, Oi-ling, Timms, Carolyn, Kalliath, Thomas, Chan, Xi Wen, Brough, Paula   +4 more
core   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Work-family Enrichment and Psychological Capital: Investigation of the Mediating Role of Stress Vulnerability

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Qum, 2020
Background and Objectives: Work-family enrichment is based on the assumption that work and family are interdependent since the gained experiences, skills, and opportunities from the workplace, improve an individualchr('39')s family life.
Fatemeh Taheri
doaj  

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Linking Work-Family Enrichment to Job Satisfaction through Job Well-Being and Family Support: A Moderated Mediation Analysis of Social Workers across India

, 2018
Social workers often experience stress from competing work and family demands, which negatively affects their job well-being and subsequently their job satisfaction. Yet, social workers can experience enrichment from participating in both work and family
Chan, Christopher, Kalliath, Thomas, Chan, Xi wen, Parveen Kalliath, Christopher Chan, Chan, Christopher C. A., Thomas Kalliath, Kalliath, Parveen, Xi Wen Chan   +8 more
core   +1 more source