Results 111 to 120 of about 1,613,013 (264)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Children of same-sex couples in the United Kingdom [PDF]
, 2008 To further develop an understanding of psychological and social functioning of children raised by lesbian couples, the current investigation compared 18 students ages 12 through 16 raised in families led by female same-sex couples who were identified ...
Noret, N, Poteat, V P, Rivers, I
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Adolescent interpersonal problem solving and family functioning
, 1983 The relationship between family functioning and interpersonal problem solving during adolescence are investigated in this study. Two self-report questionnaires were administered to a sample of 413 adolescents (183 boys and 230 girls aged between 14 and ...
Roelofse, P. R.
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Life Domain Research Report Series: School and Employment (2010 UPDATE) [PDF]
, 2008 Earlier research by the Partnerships for Children and Families Project on the daily living realities of youth and children involved with mental health services, particularly residential treatment, revealed the ongoing and pervasive nature of difficulties
Cameron, Gary +3 more
core +2 more sources
Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition
Molecular Oncology, EarlyView.We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li +10 more
wiley +1 more source
Comparing Family Functioning Levels in Individuals Using the MMPI-2 [PDF]
, 2009 Previous research has demonstrated a relationship between poor family functioning (i.e. poor communication, a lack of bonding and cohesion, and family conflict) and problems within individual areas (i.e. juvenile delinquency, social adjustment, substance
Kaverman, Kristen
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Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
The impact of Sure Start local programmes on seven year olds and their families [PDF]
, 2012 This research report presents the findings of a longitudinal study into the impact of Sure Start local programmes (SSLPs) on 7-year-olds and their families.
Belsky, Jay +2 more
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