Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
Next steps for the East, Central and Southern Africa College of Family Physicians (ECSA-CFP)
African Journal of Primary Health Care & Family MedicineNo abstract available.
Innocent K. Besigye +4 more
doaj +1 more source
The role of histone modifications in transcription regulation upon DNA damage
FEBS Letters, EarlyView.This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley +1 more source
A Patient Centered Intervention to Promote Primary Care Based Screening for Diabetic Retinopathy [PDF]
, 2018 Diabetic Retinopathy is the leading cause of blindness in patient\u27s age 25-74 in the world. Onset of disease is insidious and early intervention is the only way to reduce morbidity.
Earle, William B
core +1 more source
Systemic Racism and Health Disparities: A Statement from Editors of Family Medicine Journals [PDF]
, 2020 Sexton
openalex +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Responses of Diabetes Mellitus Patients Who Used Complementary Medicine [PDF]
, 2016 Diabetes Mellitus as a chronic disease tend to seek appropriate medical treatment to heal the condition. Health-seek searched can be either medical treatment or Complementary and Alternative Medicine.
Agil, M. (Mangestuti) +4 more
core
Mechanisms of parasite‐mediated disruption of brain vessels
FEBS Letters, EarlyView.Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira +3 more
wiley +1 more source
Family Medicine Symposium (FMGSS) 2023
McGill Journal of Medicine, 2023 Family Medicine Graduate Student Society at McGill University
doaj +1 more source
Teaching evidence based medicine in family medicine
Acta Medica Academica, 2012 The concept of evidence based medicine (EBM) as the integrationof clinical expertise, patient values and the best evidence was introduced by David Sackett in the 1980’s.
Davorka Vrdoljak
doaj