Results 91 to 100 of about 4,028,565 (349)

The anticancer effect of the HDAC inhibitor belinostat is enhanced by inhibitors of Bcl‐xL or Mcl‐1 in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine   +10 more
wiley   +1 more source

Recycling the evidence: Different approaches to the reanalysis of elite life histories [PDF]

open access: yes, 2008
The chapter considers the re-analysis of a specific data set, the life histories of a select group of pioneers of geriatric medicine collected by Professor Margot Jefferys' in 1991.
Bornat, Joanna, Wilson, Gail
core  

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

Radiology and family medicine [PDF]

open access: yes, 1997
published_or_final_versio
Peh, WCG
core  

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

open access: yesMolecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton   +17 more
wiley   +1 more source

Education in Family Medicine : What has been achieved? [PDF]

open access: yes, 2012
Contents: Education... historical landmarks - Pierre Mallia; The Malta College of Family Doctors and the Royal College of General Practitioners - John V.
Agius, Dominic   +2 more
core  

Teaching Family Medicine - what, why and where

open access: yesSouth African Family Practice, 2003
Inaugural address as Professor in Family Medicine, University of Pretoria, 28th May 2002. Julia Blitz-Lindeque graduated with MBBCh from Wits.
J.J. Blitz-Lindeque
doaj   +1 more source

Dose‐dependent induction of epithelial‐mesenchymal transition in 3D melanoma models by non‐thermal plasma treatment

open access: yesMolecular Oncology, EarlyView.
Non‐thermal plasma treatment of melanoma cells induced epithelial‐mesenchymal transition (EMT) in a dose‐dependent fashion. This report highlights the critical need to further investigate potential adverse effects of non‐thermal plasma for cancer therapy and to optimize treatment parameters for clinical translation. Despite the promising results of non‐
Eline Biscop   +10 more
wiley   +1 more source

[Review of] Louise Erdrich. Love Medicine [PDF]

open access: yes, 1986
Love Medicine brings together the stories of the Kashpaws and Lamartines, two Chippewa families of North Dakota. Two major themes, love and death, produce both the continuity of the novel and of family traditions that are the foundation of each character\
Brydon, Barbara
core   +1 more source

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