Results 121 to 130 of about 13,953,274 (395)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Does one have to be queer to care for queer patients? A qualitative interview study with general practitioners in Germany

European Journal of General Practice
Background LGBT* (lesbian, gay, bisexual, trans, others) individuals are known to experience poorer health and restricted access to healthcare compared to cisgender-heterosexual individuals.Objective As General Practitioners (GPs) are a patient’s first ...
Malte Radde, Philip Oeser, Anna Sophia Wittenstein, Eric Blumenauer, Marc Sebastian Melz, Wolfram J. Herrmann   +5 more
doaj   +1 more source

Onward Migration from an Aspirations–Capabilities Framework: The Multi-sited Transnational Practices of Sudanese Families Across Europe, Sudan and Beyond [PDF]

, 2022
Ester Serra Mingot
openalex   +1 more source

Ethical issues in family practice [PDF]

, 2001
The Raison d'etre principles in biomedical ethics have clearly become what are referred to as the four principles. These can be summarized as the Principles of Beneficence, Nonmaleficence, Respect for Autonomy and Justice.
Mallia, Pierre
core  

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Professional development of medical students – piloting a longitudinal curriculum at Jena University Hospital (LongProf)

GMS Journal for Medical Education
Background: Professionalism is an important prerequisite for the quality of medical care with specific competencies anchored in the National Competence-Based Learning Objectives Catalogue Medicine 2.0.
Schmidt, Konrad, Siller, Katharina, Rißmann, Jens, Andlauer, Marie, Feustel, Jana, Klein, Friederike, Petruschke, Inga, Schulz, Sven   +7 more
doaj   +1 more source

South African Family Practice incorporating Geneeskunde!

South African Family Practice, 2003
No abstract available.
Pierre J.T. de Villiers, Douw Greef
doaj   +1 more source

A Review of Instruments for Assessing Family History [PDF]

, 1998
The influence of family history on one\u27s development has long been a focus of psychological theory, research, and practice. In recent years, however, conceptualizations of family influences on development have evolved considerably, and there has also ...
Melchert, Timothy P.
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Factors Influencing Immunization Status in Primary Care Clinics

, 2002
Background and Objectives: National standards and goals for childhood immunization rates are well established. Yet, despite clear standards and goals, physicians do not achieve the desired rate (90%) for immunization coverage. This study examined factors
Dailey, Amy B., Meires, Jan, Page, David
core