Results 1 to 10 of about 8,375 (152)

Human Fanconi anemia complementation group a protein stimulates the 5' flap endonuclease activity of FEN1. [PDF]

PLoS ONE, 2013
In eukaryotic cells, Flap endonuclease 1 (FEN1) is a major structure-specific endonuclease that processes 5' flapped structures during maturation of lagging strand DNA synthesis, long patch base excision repair, and rescue of stalled replication forks ...
Liangyue Qian, Fenghua Yuan, Paola Rodriguez-Tello, Suyog Padgaonkar, Yanbin Zhang   +4 more
doaj   +5 more sources

Damage-dependent regulation of MUS81-EME1 by Fanconi anemia complementation group A protein. [PDF]

Nucleic Acids Res, 2014
MUS81-EME1 is a DNA endonuclease involved in replication-coupled repair of DNA interstrand cross-links (ICLs). A prevalent hypothetical role of MUS81-EME1 in ICL repair is to unhook the damage by incising the leading strand at the 3' side of an ICL lesion.
Benitez A, Yuan F, Nakajima S, Wei L, Qian L, Myers R, Hu JJ, Lan L, Zhang Y.   +8 more
europepmc   +4 more sources

A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M [PDF]

Nature Genetics, 2005
Fanconi anemia is a genetic disease characterized by genomic instability and cancer predisposition. Nine genes involved in Fanconi anemia have been identified; their products participate in a DNA damage-response network involving BRCA1 and BRCA2 (refs. 2,3).
Meetei, A R, Medhurst, Al, Ling, C, Xue, Y, Singh, T R, Bier, P, Steltenpool, J, Stone, S, Dokal, I, Mathew, C G, Hoatlin, M, Joenje, H, de Winter, J P, Wang, W   +13 more
openaire   +6 more sources

Identification of FANCG as a prognostic factor for prostate cancer [PDF]

European Journal of Medical Research
Background To ascertain role of the fanconi anemia complementation group G (FANCG) gene in prostate cancer (PCa) and the suitability of the FANCG gene as a prognostic biomarker for PCa.
Wenlong Gao, Peng Liu, Han Xinyue, Yuanjie Niu, Wu Yi   +4 more
doaj   +2 more sources

Betulinic Acid Suppresses UBE2T Expression via MAPK/ERK Inhibition to Block FANCI and FANCD2 Monoubiquitination in Glioblastoma. [PDF]

J Cell Mol Med
ABSTRACT Platinum‐based chemotherapy remains a cornerstone of glioma treatment, yet resistance driven by the Fanconi anaemia (FA) DNA repair pathway limits efficacy. Here, we identified betulinic acid (BA) as a potent inhibitor of FA pathway activation.
Bao Y, Wang M.
europepmc   +2 more sources

FANCD2 limits acetaldehyde‐induced genomic instability during DNA replication in esophageal keratinocytes

Molecular Oncology, 2021
Individuals with Fanconi anemia (FA), a rare genetic bone marrow failure syndrome, have an increased risk of young‐onset head and neck squamous cell carcinomas (SCCs) and esophageal SCC.
Jasmine D. Peake, Chiaki Noguchi, Baicheng Lin, Amber Theriault, Margaret O'Connor, Shivani Sheth, Koji Tanaka, Hiroshi Nakagawa, Eishi Noguchi   +8 more
doaj   +1 more source

Fanconi Anemia Complementation Group A (FANCA) Protein Has Intrinsic Affinity for Nucleic Acids with Preference for Single-stranded Forms [PDF]

Journal of Biological Chemistry, 2012
The Fanconi anemia complementation group A (FANCA) gene is one of 15 disease-causing genes and has been found to be mutated in ∼60% of Fanconi anemia patients. Using purified protein, we report that human FANCA has intrinsic affinity for nucleic acids.
Fenghua, Yuan, Liangyue, Qian, Xinliang, Zhao, Jesse Y, Liu, Limin, Song, Gennaro, D'Urso, Chaitanya, Jain, Yanbin, Zhang   +7 more
openaire   +2 more sources

Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair [PDF]

Proceedings of the National Academy of Sciences, 2012
The Fanconi anemia (FA) pathway participates in interstrand cross-link (ICL) repair and the maintenance of genomic stability. The FA core complex consists of eight FA proteins and two Fanconi anemia-associated proteins (FAAP24 and FAAP100). The FA core complex has ubiquitin ligase activity responsible for monoubiquitination of the FANCI-FANCD2 (ID ...
Chen, J, Leung, JWC, Wang, Y, Fong, KW, Huen, MSY, Li, L   +5 more
openaire   +4 more sources

FANCD2 as a novel prognostic biomarker correlated with immune and drug therapy in Hepatitis B-related hepatocellular carcinoma

European Journal of Medical Research, 2023
Background Ferroptosis is related to the immunosuppression of tumors and plays a critical role in cancer progression. Fanconi anemia complementation group D2 (FANCD2) is a vital gene that regulates ferroptosis.
Xiaowei Tang, Bei Luo, Shu Huang, Jiao Jiang, Yuan Chen, Wensen Ren, Xiaomin Shi, Wei Zhang, Lei Shi, Xiaolin Zhong, Muhan Lü   +10 more
doaj   +1 more source

A deficiency in a 230 kDa DNA repair protein in Fanconi anemia complementation group A cells is corrected by the FANCA cDNA [PDF]

Carcinogenesis, 1999
Cells from individuals with the cancer-prone, inherited disorder Fanconi anemia (FA) are hypersensitive to DNA interstrand cross-linking agents and this hypersensitivity correlates with a defect in ability to repair this type of damage to their DNA. We have isolated a DNA endonuclease complex from the nuclei of normal human cells which is involved in ...
D W, Brois, L W, McMahon, N I, Ramos, L M, Anglin, C E, Walsh, M W, Lambert   +5 more
openaire   +2 more sources