Farnesoid X receptor (FXR): Structures and ligands
Computational and Structural Biotechnology Journal, 2021 Farnesoid X receptor (FXR) is a bile acid activated nuclear receptor (BAR) and is mainly expressed in the liver and intestine. Upon ligand binding, FXR regulates key genes involved in the metabolic process of bile acid synthesis, transport and ...
Longying Jiang +4 more
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Natural Products Targeting Liver X Receptors or Farnesoid X Receptor [PDF]
Frontiers in Pharmacology, 2022 Nuclear receptors (NRs) are a superfamily of transcription factors induced by ligands and also function as integrators of hormonal and nutritional signals.
Jianglian She +9 more
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Farnesoid X Receptor Agonists: A Promising Therapeutic Strategy for Gastrointestinal Diseases [PDF]
Gastro Hep Advances, 2023 Farnesoid X receptor (FXR) agonists have emerged as a promising therapeutic strategy for the management of various gastrointestinal (GI) diseases, including primary biliary cholangitis, nonalcoholic fatty liver disease, inflammatory bowel disease ...
Mohammad Almeqdadi, Fredric D. Gordon
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Targeting farnesoid X receptor as aging intervention therapy [PDF]
Acta Pharmaceutica Sinica BEnvironmental toxicants have been linked to aging and age-related diseases. The emerging evidence has shown that the enhancement of detoxification gene expression is a common transcriptome marker of long-lived mice, Drosophila melanogaster, and ...
Lijun Zhang +12 more
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Farnesoid X receptor activation by bile acids suppresses lipid peroxidation and ferroptosis [PDF]
Nature Communications, 2023 Ferroptosis is a regulated cell death modality that occurs upon iron-dependent lipid peroxidation. Recent research has identified many regulators that induce or inhibit ferroptosis; yet, many regulatory processes and networks remain to be elucidated.
Juliane Tschuck +15 more
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Tissue specific induction of p62/Sqstm1 by farnesoid X receptor. [PDF]
PLoS ONE, 2012 Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily and is a ligand-activated transcription factor essential for maintaining liver and intestinal homeostasis.
Jessica A Williams +8 more
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Farnesoid X Receptor, Bile Acid Metabolism, and Gut Microbiota
Metabolites, 2022 Obesity, type 2 diabetes, and non-alcoholic fatty liver disease (NAFLD) are characterized by the concepts of lipo- and glucotoxicity. NAFLD is characterized by the accumulation of different lipidic species within the hepatocytes. Bile acids (BA), derived
Hideki Mori +7 more
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Farnesoid X receptor: From Structure to Function and Its Pharmacology in Liver Fibrosis. [PDF]
Aging Dis, 2023 The farnesoid X receptor (FXR), a ligand-activated transcription factor, plays a crucial role in regulating bile acid metabolism within the enterohepatic circulation.
Ding C +12 more
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Stimulation of the farnesoid X receptor promotes M2 macrophage polarization
Frontiers in Immunology, 2023 FXR is a key molecule that modulates anti-inflammatory activity in the intestinal-liver axis. Although FXR has pleiotropic functions including regulation of liver inflammation and activation of macrophages, it remains unclear whether it is involved in ...
Thiranut Jaroonwitchawan +11 more
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Targeting Farnesoid X receptor (FXR) for developing novel therapeutics against cancer
Molecular Biomedicine, 2021 Cancer is one of the lethal diseases that arise due to the molecular alterations in the cell. One of those alterations associated with cancer corresponds to differential expression of Farnesoid X receptor (FXR), a nuclear receptor regulating bile ...
Sosmitha Girisa +5 more
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