Results 11 to 20 of about 114,798 (264)
Molecular tuning of farnesoid X receptor partial agonism [PDF]
Nature Communications, 2019 The ligand-activated transcription factor farnesoid X receptor (FXR) acts as a cellular sensor for bile acids and is of interest as a drug target. Here the authors employ X-ray crystallography and NMR to characterize the molecular determinants of FXR ...
Daniel Merk +14 more
doaj +4 more sources
The Farnesoid X Receptor: Good for BADSummary [PDF]
Cellular and Molecular Gastroenterology and Hepatology, 2016 Diarrhea is a feature of several chronic intestinal disorders that are associated with increased delivery of bile acids into the colon. Although the prevalence of bile acid diarrhea is high, affecting approximately 1% of the adult population, current ...
Stephen J. Keely, Julian R.F. Walters
doaj +6 more sources
Aquaporin-8 ameliorates hepatic steatosis through farnesoid X receptor in obese mice [PDF]
iScience, 2023 Summary: Aquaporin-8(AQP8), is a transmembrane channel protein that abounds in liver, which mainly promotes water transport, modulating bile acid formation. However, its role in hepatic lipid metabolism remains unclear.
Minqi Xiang +11 more
doaj +4 more sources
Farnesoid X receptor represses hepatic lipase gene expression [PDF]
Journal of Lipid Research, 2004 The farnesoid X receptor (FXR) is a nuclear receptor that regulates gene expression in response to bile acids (BAs). FXR plays a central role in BA, cholesterol, and lipoprotein metabolism.
Audrey Sirvent +7 more
doaj +4 more sources
Computational study of novel natural agonists targeting farnesoid X receptor [PDF]
Scientific ReportsThe farnesoid X receptor (FXR) is a crucial therapeutic target for treating non-alcoholic steatohepatitis (NASH). Although obeticholic acid (OCA) as a FXR agonist presents good efficacy, the safety data such as severe pruritus should be carefully ...
Xindan Hu, Junliang Ge, Ying Wen
doaj +2 more sources
Farnesoid X receptor and fibroblast growth factor 15/19 as pharmacological targets
Liver Research, 2021 The farnesoid X receptor (FXR) is a nuclear receptor and transcriptional regulator activated by bile acids or synthetic FXR agonists. FXR is expressed highly in the liver and intestine where modulation of FXR critically regulates the expression of genes ...
Syeda Maliha, Grace L. Guo
doaj +2 more sources
Farnesoid X receptor and liver X receptor ligands initiate formation of coated platelets [PDF]
Arteriosclerosis, Thrombosis, and Vascular Biology, 2017 The liver X receptors (LXRs) and farnesoid X receptor (FXR) have been identified in human platelets. Ligands of these receptors have been shown to have nongenomic inhibitory effects on platelet activation by platelet agonists.
Alberio L +15 more
core +7 more sources
Farnesoid X receptor activation inhibits pancreatic carcinogenesis. [PDF]
Biochim Biophys Acta Mol Basis Dis, 2023 Farnesoid X receptor (FXR), a member of the nuclear receptor superfamily that controls bile acid (BA) homeostasis, has also been proposed as a tumor suppressor for breast and liver cancer. However, its role in pancreatic ductal adenocarcinoma (PDAC) tumorigenesis remains controversial.
Xu Z +10 more
europepmc +3 more sources
Experimental and Molecular Medicine, 2023 The prevalence of kidney diseases has been increasing worldwide due to the aging population and has results in an increased socioeconomic burden as well as increased morbidity and mortality.
Dong-Hyun Kim +6 more
semanticscholar +1 more source
Bacterial metabolites directly modulate farnesoid X receptor activity [PDF]
Nutrition & Metabolism, 2015 The farnesoid X receptor (FXR), a ligand-activated transcription factor belonging to the adopted orphan receptor, plays an important role in maintaining health of the liver and intestine. In this study, we identified individual bacterial strains that directly modulated the activation of intestinal FXR.The FXR stimulatory potential of 38 bacterial ...
Satoshi Tsuneda +2 more
core +4 more sources