Results 31 to 40 of about 114,798 (264)

Hepatocellular cystathionine γ lyase/hydrogen sulfide attenuates nonalcoholic fatty liver disease by activating farnesoid X receptor

Hepatology, 2022
Hydrogen sulfide (H2S) plays a protective role in NAFLD. However, whether cystathionine γ lyase (CSE), a dominant H2S generating enzyme in hepatocytes, has a role in the pathogenesis of NAFLD is currently unclear.
Wenjing Xu, Changting Cui, Chunmei Cui, Zhenzhen Chen, Haizeng Zhang, Qinghua Cui, Guoheng Xu, Ji-Mim Fan, Yu Han, Liangjie Tang, G. Targher, C. Byrne, M. Zheng, Liming Yang, Jun Cai, B. Geng   +15 more
semanticscholar   +1 more source

Farnesoid-X receptor as a therapeutic target for inflammatory bowel disease and colorectal cancer

Frontiers in Pharmacology, 2022
Farnesoid-X receptor (FXR), as a nuclear receptor activated by bile acids, is a vital molecule involved in bile acid metabolism. Due to its expression in immune cells, FXR has a significant effect on the function of immune cells and the release of ...
Mengjiao Zhou, Danfeng Wang, Xiang Li, Ying Cao, Chengxue Yi, Dickson Kofi Wiredu Ocansey, Yuling Zhou, Fei Mao   +7 more
semanticscholar   +1 more source

Farnesoid X receptor: docking model validation [PDF]

, 2008
Abreu, Rui M.V., Ferreira, Isabel C.F.R., Froufe, Hugo J.C.   +2 more
core   +2 more sources

Guggulsterone –Farnesoid X receptor interaction [PDF]

Journal of Pharmacognosy and Phytochemistry, 2018
The present investigation entitled “Correlation, path analysis, heritability and genetic advance for morpho-physiological characters in bread wheat (Triticum aestivum L.)” was undertaken to study the Correlation, path analysis, heritability and genetic advance for grain yield and its components in F1 generation of wheat through Line X Tester ...
Prutha Parmar, Swarali Bhoir, Pravin P Naik, Sandeep Waghulde, Nilesh Gorde, MK Kale   +5 more
openaire   +1 more source

Mesenchymal Stromal Cells Overexpressing Farnesoid X Receptor Exert Cardioprotective Effects Against Acute Ischemic Heart Injury by Binding Endogenous Bile Acids

Advancement of science, 2022
Bile acid metabolites have been increasingly recognized as pleiotropic signaling molecules that regulate cardiovascular functions, but their role in mesenchymal stromal cells (MSC)‐based therapy has never been investigated.
Yu-yi Xia, Xin-Yue Xu, Yongzheng Guo, Chen Lin, Xiaoming Xu, Fuyang Zhang, M. Fan, Tingting Qi, Congye Li, Guangyu Hu, Lu Peng, Shan Wang, Ling Zhang, C. Hai, R. Liu, Wenjun Yan, L. Tao   +16 more
semanticscholar   +1 more source

Microbiota-induced obesity requires farnesoid X receptor [PDF]

Gut, 2016
ObjectiveThe gut microbiota has been implicated as an environmental factor that modulates obesity, and recent evidence suggests that microbiota-mediated changes in bile acid profiles and signalling through the bile acid nuclear receptor farnesoid X receptor (FXR) contribute to impaired host metabolism.
Parséus, Ava, Sommer, Nina, Sommer, Felix, Caesar, Robert, Molinaro, Antonio, Ståhlman, Marcus, Greiner, Thomas U, Perkins, Rosie, Bäckhed, Gert Fredrik   +8 more
openaire   +4 more sources

Regulation of Multidrug Resistance-associated Protein 2 (ABCC2) by the Nuclear Receptors Pregnane X Receptor, Farnesoid X-activated Receptor, and Constitutive Androstane Receptor*

Journal of Biological Chemistry, 2002
The multidrug resistance-associated protein 2 (MRP2, ABCC2), mediates the efflux of several conjugated compounds across the apical membrane of the hepatocyte into the bile canaliculi.
H. R. Kast, B. Goodwin, Paul T. Tarr, Stacey A. Jones, A. Anisfeld, C. Stoltz, P. Tontonoz, S. Kliewer, T. Willson, P. Edwards   +9 more
semanticscholar   +1 more source

The Farnesoid X Receptor as a Master Regulator of Hepatotoxicity

International Journal of Molecular Sciences, 2022
The nuclear receptor farnesoid X receptor (FXR, NR1H4) is a bile acid (BA) sensor that links the enterohepatic circuit that regulates BA metabolism and elimination to systemic lipid homeostasis.
M. Rausch, Sophia L. Samodelov, M. Visentin, G. Kullak-Ublick   +3 more
semanticscholar   +1 more source

Gender Differences in Bile Acids and Microbiota in Relationship with Gender Dissimilarity in Steatosis Induced by Diet and FXR Inactivation. [PDF]

, 2017
This study aims to uncover how specific bacteria and bile acids (BAs) contribute to steatosis induced by diet and farnesoid X receptor (FXR) deficiency in both genders.
French, Samuel W, Gonzalez, Frank J, Jena, Prasant Kumar, Kalanetra, Karen M, Krishnan, Viswanathan V, Liu, Hui-Xin, Mills, David A, Sheng, Lili, Wan, Yu-Jui Yvonne   +8 more
core   +1 more source

DOT1L Epigenetically Regulates Autophagy and Mitochondria Fusion in Cell Lines of Renal Cancer

Technology in Cancer Research & Treatment, 2023
Objectives DOT1L, a histone methylase, is overexpression in renal cell cancer. However, the role and detailed molecular mechanism of DOT1L involved in renal cancer development remain unknown.
Yanguang Hou MD, Jiachen Liu MD, Shiyu Huang MD, Lei Wang MD, Juncheng Hu PhD, Xiuheng Liu MD, PhD   +5 more
doaj   +1 more source