Results 51 to 60 of about 114,798 (264)

Nuclear Receptors as Targets for Drug Development: Regulation of Cholesterol and Bile Acid Metabolism by Nuclear Receptors

Journal of Pharmacological Sciences, 2005
Nuclear receptors are ligand-dependent transcription factors that recently have been shown to play important roles in the metabolism of cholesterol and bile acids.
Makoto Makishima
doaj   +1 more source

Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice [PDF]

Carcinogenesis, 2006
The farnesoid X receptor (FXR) controls the synthesis and transport of bile acids (BAs). Mice lacking expression of FXR, designated Fxr-null, have elevated levels of serum and hepatic BAs and an increase in BA pool size. Surprisingly, at 12 months of age, male and female Fxr-null mice had a high incidence of degenerative hepatic lesions, altered cell ...
Insook, Kim, Keiichirou, Morimura, Yatrik, Shah, Qian, Yang, Jerrold M, Ward, Frank J, Gonzalez   +5 more
openaire   +2 more sources

Bile Acids and Their Value for Central Nervous System

Российский журнал гастроэнтерологии, гепатологии, колопроктологии, 2022
Aim. A review to highlight the bile acids importance as steroid mediators of nervous system activity and show the nervous system involvement in cholesterol metabolism and bile acids production.Key points.
Yu. O. Shulpekova, P. E. Tkachenko, E. N. Shirokova, I. V. Damulin   +3 more
doaj   +1 more source

Mast Cells Regulate Ductular Reaction and Intestinal Inflammation in Cholestasis Through Farnesoid X Receptor Signaling

Hepatology, 2021
Cholestasis is characterized by increased total bile acid (TBA) levels, which are regulated by farnesoid X receptor (FXR)/FGF15. Patients with primary sclerosing cholangitis (PSC) typically present with inflammatory bowel disease (IBD). Mast cells (MCs) (
Vik Meadows, Lindsey Kennedy, B. Ekser, Konstantina Kyritsi, Debjyoti Kundu, Tianhao Zhou, Lixian Chen, L. Pham, Nan Wu, Jennifer Demieville, Laura A Hargrove, S. Glaser, G. Alpini, H. Francis   +13 more
semanticscholar   +1 more source

Regulation of bile acid receptor activity

Liver Research, 2018
Many receptors can be activated by bile acids (BAs) and their derivatives. These include nuclear receptors farnesoid X receptor (FXR), pregnane X receptor (PXR), and vitamin D receptor (VDR), as well as membrane receptors Takeda G protein receptor 5 ...
Yu-Jui Yvonne Wan, Lili Sheng
doaj   +1 more source

Effect of a Farnesoid X-receptor Agonist on Postprandial Lipemia in Rats Fed a Supraphysiological Fat Dozes

Разработка и регистрация лекарственных средств, 2023
Introduction. One of the most progressive directions of the modern stage of development of biology is the deepening of knowledge about the mechanisms of regulation of metabolic processes, in particular about signal molecules that transmit information to ...
Yu. N. Alekhin, O. S. Popova, V. S. Ponamarev, P. A. Parshin   +3 more
doaj   +1 more source

The Brain-Gut-Microbiome Axis. [PDF]

, 2018
Preclinical and clinical studies have shown bidirectional interactions within the brain-gut-microbiome axis. Gut microbes communicate to the central nervous system through at least 3 parallel and interacting channels involving nervous, endocrine, and ...
Kalani, Amir, Martin, Clair R, Mayer, Emeran A, Osadchiy, Vadim   +3 more
core   +2 more sources

Altered ethanol metabolism and increased oxidative stress enhance alcohol‐associated liver injury in farnesoid X receptor‐deficient mice

Liver international (Print), 2022
Pharmacological activation of farnesoid X receptor (FXR) ameliorates liver injury, steatosis and inflammation in mouse models of alcoholic liver disease (ALD), but the underlying mechanisms of the protective effect of FXR against ALD remain unclear.
C. Morel, Vivek K. Chowdhary, Prashanth Thevkar Nagesh, Marcelle Ribeiro, Danielle Hawryluk, D. Catalano, L. Adorini, G. Szabo   +7 more
semanticscholar   +1 more source

Identification of PLTP as an LXR target gene and apoE as an FXR target gene reveals overlapping targets for the two nuclear receptors

Journal of Lipid Research, 2002
Affymetrix microarray data and Northern blot assays demonstrated that phospholipid transfer protein (PL222222222216) was induced 6-fold when either murine or human macrophages were incubated in the presence of ligands for the liver X receptor (LXR) and ...
Puiying A. Mak, Heidi R. Kast-Woelbern, Andrew M. Anisfeld, Peter A. Edwards   +3 more
doaj   +1 more source

The FXR agonist obeticholic acid inhibits the cancerogenic potential of human cholangiocarcinoma [PDF]

, 2019
Cholangiocarcinoma (CCA) is an aggressive cancer with high resistance to chemotherapeutics. CCA is enriched in cancer stem cells, which correlate with aggressiveness and prognosis.
Adorini, L., Alvaro, D., Berloco, P. B., Bragazzi, M., Cardinale, V., Carpino, G., Costantini, D., De Rose, A. M., Di Matteo, S., Gaudio, E., Giorgi, A., Giuliante, F., Giulitti, F., Grazi, G., Manzi, E., Melandro, F., Napoletano, C., Nevi, L., Overi, D., Safarikia, S.   +19 more
core   +3 more sources