Farnesoid X Receptor Agonists as Therapeutic Target for Cardiometabolic Diseases
Frontiers in Pharmacology, 2020 Cardiometabolic diseases are characterized as a combination of multiple risk factors for cardiovascular disease (CVD) and metabolic diseases including diabetes mellitus and dyslipidemia.
Chao Li +6 more
doaj +1 more source
Ligand-biased ensemble receptor docking (LigBEnD): a hybrid ligand/receptor structure-based approach. [PDF]
, 2017 Ligand docking to flexible protein molecules can be efficiently carried out through ensemble docking to multiple protein conformations, either from experimental X-ray structures or from in silico simulations.
Abagyan, Ruben +2 more
core +2 more sources
Farnesoid X receptor agonist for the treatment of chronic hepatitis B: A safety study
Journal of Viral Hepatitis, 2021 The nuclear farnesoid X receptor (FXR) regulates bile acid homeostasis and is a drug target for metabolic liver diseases. FXR also plays an important role in hepatitis B virus (HBV) DNA transcription.
Robin Erken +13 more
semanticscholar +1 more source
Farnesoid X receptor, the bile acid sensing nuclear receptor, in liver regeneration
Acta Pharmaceutica Sinica B, 2015 The liver is unique in regenerative potential, which could recover the lost mass and function after injury from ischemia and resection. The underlying molecular mechanisms of liver regeneration have been extensively studied in the past using the partial ...
Guodong Li, Grace L. Guo
doaj +1 more source
Bile acids at the cross-roads of gut microbiome–host cardiometabolic interactions [PDF]
, 2017 This work is supported in part by the APC Microbiome Institute (under Science Foundation Ireland [SFI] Grant Number: SFI/12/RC/2273) and by Enterprise Ireland Commercialization Fund (Contract Reference: CF/2013/3030A/B).peer-reviewedWhile basic and ...
Caplice, Noel M +2 more
core +3 more sources
Neurochemical Research, 2021 Neuroinflammation plays an important role in the onset and progression of neurodegenerative diseases. Microglia-mediated neuroinflammation have been proved to be the main reason for causing the neurodegenerative diseases. Ganoderic acid A (GAA), isolated
Yue Jia +5 more
semanticscholar +1 more source
Gut Microbial Metabolism and Nonalcoholic Fatty Liver Disease. [PDF]
, 2019 The gut microbiome, the multispecies community of microbes that exists in the gastrointestinal tract, encodes several orders of magnitude more functional genes than the human genome. It also plays a pivotal role in human health, in part due to metabolism
Lynch, Susan V +3 more
core +1 more source
The relationship between gut microbiota and spontaneous bacterial peritonitis in patients with liver cirrhosis - a literature review [PDF]
, 2019 Gut microbiota is an essential component in the pathogenesis of liver cirrhosis and its complications. There is a direct relationship between the gut and the liver called the gutliver axis through which bacteria can reach the liver through the portal ...
Fierbinteanu Braticevici, Carmen +9 more
core +3 more sources
Farnesoid X Receptor as Target for Therapies to Treat Cholestasis-Induced Liver Injury
Cells, 2021 Recent studies on liver disease burden worldwide estimated that cirrhosis is the 11th most common cause of death globally, and there is a great need for new therapies to limit the progression of liver injuries in the early stages.
A. Petrescu, S. DeMorrow
semanticscholar +1 more source
Role of metabolic nuclear receptors in acute liver injury and drug-induced hepatotoxicity
Pharmacological ResearchMetabolic nuclear receptors (NRs) are ligand-activated transcription factors central to metabolic homeostasis and detoxification. While their roles in chronic liver diseases have been reviewed, comprehensive reviews specifically addressing the role of ...
Liangliang Nie +4 more
doaj +1 more source