Results 51 to 60 of about 2,749 (133)

Differential gene expression toward species of Aristolochia impairing the performance of the Troidini butterfly Battus polydamas

Entomologia Experimentalis et Applicata, Volume 173, Issue 7, Page 696-707, July 2025.
We studied the response of Battus polydamas (Papilionidae) larvae fed on Aristolochia ringens (containing several diterpenes) and Aristolochia gigantea (containing sesquiterpenes and acyclic monoterpenoids but no diterpenoids or aristolochic acids). We assessed larval performance on fitness components such as survival and differential gene expression ...
Karina L. Silva‐Brandão, Clécio Fernando Klitzke, Marcelo M. Brandão, José Roberto Trigo   +3 more
wiley   +1 more source

Human γδ T Cell Function Is Impaired Upon Mevalonate Pathway Inhibition

Immunology, Volume 175, Issue 3, Page 300-322, July 2025.
Mevalonate pathway is important for the effector function of gammadelta T cells. Inhibition of the pathway in vivo and in vitro impairs cytokine and cytotoxic molecule production by mainly affecting protein prenylation and disturbing intracellular signalling in Vdelta2 T cells. Created with Biorender.
Tsz Kin Suen, Burcu Al, Thomas Ulas, Nico Reusch, Harsh Bahrar, Siroon Bekkering, Jaydeep Bhat, Dieter Kabelitz, Joachim L. Schultze, Frank L. van de Veerdonk, Jeanine Roeters van Lennep, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea, Katarzyna Placek   +14 more
wiley   +1 more source

Screening of prenyldiphosphate mimetics for their potential to inhibit 4-hydroxybenzoate oligoprenyl transferase [PDF]

, 2017
4-Hydroxybenzoat-Oligoprenyl-Transferase (UbiA-Prenyltransferase) ist ein wichtiges Enzym in der Ubichinon-Biosynthese von E. coli. Es katalysiert die Prenylierung von 4-Hydroxybenzoat (4-HB) an Position 3 zu 3-Oligoprenyl-4-Hydroxybenzoat ...
Msonga, Amina
core   +1 more source

A Biosynthetic and Taxonomic Atlas of the Global Lichen Holobiont

Environmental Microbiology, Volume 27, Issue 6, June 2025.
This analysis of 794 publicly available lichen shotgun metagenomic datasets, covering 467 unique lichen species from 34 countries, revealed that lichens are complex holobionts. They harbour a variety of fungal, algal, and bacterial players with remarkable biosynthetic capabilities.
Samantha C. Waterworth, Susan Egbert, John Sorensen, Barry R. O'Keefe, John A. Beutler   +4 more
wiley   +1 more source

Impact of Mutational Status on Intracellular Effects of Cell‐Permeable CaaX Peptides in Pancreatic Cancer Cells

ChemBioChem, Volume 26, Issue 10, May 27, 2025.
This work deals with intracellular effects of cell‐permeable CaaX‐peptides, designed to influence prenylated proteins like KRas. The results show that after CaaX‐1 treatment, not only KRas expression and signaling are specifically altered in mutated pancreatic cancer cells, but also plasma membrane localization of KRas is affected.
Merlin Klußmann, Martin Matijass, Ines Neundorf   +2 more
wiley   +1 more source

EXPANDING THE POTENTIAL PRENYLOME: PRENYLATION OF SHORTENED TARGET SUBSTRATES BY FTASE AND DEVELOPMENT OF FRET-BASED SYSTEM FOR DETECTING POTENTIALLY “SHUNTED” PROTEINS [PDF]

, 2020
Protein prenylation is a posttranslational modification involving the attachment of a C15 or C20 isoprenoid group to a cysteine residue near the C-terminus of the target substrate by protein farnesyltransferase (FTase) or protein ...
Ashok, Sudhat
core   +1 more source

Disturbing Cholesterol/Sphingolipid Metabolism by Squalene Epoxidase Arises Crizotinib Hepatotoxicity

Advanced Science, Volume 12, Issue 14, April 10, 2025.
Crizotinib induces excessive accumulation of squalene epoxidase (SQLE) by blocking its autophagic degradation. This accumulation disrupts cholesterol and sphingolipid metabolism, leading to hepatic steatosis or hepatocyte apoptosis, respectively. Autophagy activators, such as metformin, or SQLE enzymatic inhibitors, like terbinafine, possesses the ...
Hao Yan, Xiangliang Huang, Yourong Zhou, Yuan Mu, Shaoyin Zhang, Yashi Cao, Wentong Wu, Zhifei Xu, Xueqin Chen, Xiaochen Zhang, Xiaohong Wang, Xiaochun Yang, Bo Yang, Qiaojun He, Peihua Luo   +14 more
wiley   +1 more source

Valproic acid induces ferroptosis and suppresses the proliferation of MDA-MB-231 cells by targeting FDFT1

Frontiers in Pharmacology
IntroductionValproic acid (VPA) constitutes a branched-chain, short-chain fatty acid that serves as an antiepileptic medication. It has been increasingly recognized that VPA has presented potential anti-tumor properties, including breast cancer. However,
Shuxian Zhang, Jiazhuo Liu, Yisong Yang, Ran Tao, Xin Ren, Xingzhi Zhou, Shuangping Liu   +6 more
doaj   +1 more source

The Role of Cholesterol Metabolism and Its Regulation in Tumor Development

Cancer Medicine, Volume 14, Issue 7, April 2025.
ABSTRACT Background Within the tumor microenvironment, tumor cells undergo metabolic reprogramming of cholesterol due to intrinsic cellular alterations and changes in the extracellular milieu. Furthermore, cholesterol reprogramming within this microenvironment influences the immune landscape of tumors, facilitating immune evasion and consequently ...
Yongmei Wu, Wenqian Song, Min Su, Jing He, Rong Hu, Youbo Zhao   +5 more
wiley   +1 more source

Identification of a Novel Class of Farnesylation Targets by Structure-Based Modeling of Binding Specificity [PDF]

, 2011
Farnesylation is an important post-translational modification catalyzed by farnesyltransferase (FTase). Until recently it was believed that a C-terminal CaaX motif is required for farnesylation, but recent experiments have revealed larger substrate ...
A Bairoch, A Brauers, A Fersht, AD Cox, AJ Krzysiak, AJ Ridley, Amy E. Keating, B Kuhlman, B Raveh, C Price, C Pucharcos, CA Rohl, CA Smith, Carol A. Fierke, CJ Marshall, Corissa L. Lamphear, CT Price, DJ Mandell, E Petsalaki, EL Humphris, FL Zhang, FS Buckner, G Grigoryan, H Ozawa, HW Fu, I Levental, J Colicelli, J Rizo, James L. Hougland, JE Pais, JE Pais, JL Hougland, JL Hougland, JM Troutman, JS Pickett, JT Snyder, K Kaufmann, KA Hicks, KL Terry, KT Lane, L Goldschmidt, L Nallan, L Tsyba, M Ashburner, M Dorn, M McGavin, MR Brouns, Nir London, Ora Schueler-Furman, P Kota, PJ Casey, PJ Kersey, R Das, S Chaudhury, S Ivanov, S Maurer-Stroh, S Maurer-Stroh, S Maurer-Stroh, SB Long, SF Sousa, SM Sebti, SM Sebti, TS Reid, W Huang da, WA Schroder, WR Tschantz, X Fu, Y Kho   +67 more
core   +4 more sources