Farnesyl-diphosphate farnesyltransferase 1

Results 71 to 80 of about 2,749 (133)

REDEFINING THE SCOPE OF PRENYLATION: DISCOVERY OF “FORBIDDEN” SUBSTRATE RECOGNITION AND DEVELOPMENT OF METHODS UTILIZING PRENYLATED PROTEINS [PDF]

, 2018
Post-translational modifications play a central role in controlling biological function and cell behavior through changes in protein structure, activity, and localization.
Blanden, Melanie Jane
core +1 more source

Induction And Regulation Of Autophagy By Novel Prenylation Inhibitors In Sts-26t Malignant Peripheral Nerve Sheath Tumor (mpnst) Cells [PDF]

, 2010
Prenylation pathways have been targeted via several different compounds that inhibit farnesyl transferase (FTase) and/or geranylgeranyl transferase (GGTase) enzymes in many cellular and animal models of cancer.
Sane, Komal Madhukar
core +1 more source

Molecular Recognition of Substrates by Protein Farnesyltransferase and Geranylgeranyltransferase-I. [PDF]

Prenylation is an important post-translational modification that targets proteins to the cellular membrane. Farnesyltransferase (FTase) catalyzes the attachment of the 15-carbon farnesyl moiety from farnesyldiphosphate to a cysteine near the C-terminus ...
Lamphear, Corissa L.
core

Mechanism of Catalysis and Inhibition of Mammalian Protein Farnesyltransferase. [PDF]

, 2007
Mammalian protein farnesyltransferase (FTase) catalyzes the transfer of a 15-carbon prenyl group from farnesyl diphosphate (FPP) to a cysteine residue near the carboxyl terminus of many proteins, including several key molecules involved in signal ...
Pais, June E.
core

Doctor of Philosophy [PDF]

, 2012
dissertationArchaea utilize the mevalonate (MVA) pathway for the biosynthesis of isopentenyl diphosphate (IPP) and its isomer, dimethylallyl diphosphate (DMAPP), the two building blocks of all isoprenoids.
Mabanglo, Mark Noel F.
core

Mutant drought phenotype investigation : a look into effects of protein prenylation on water utilization in conditions of varying soil saturation and gene knockout. [PDF]

, 2013
Plants respond to environmental stress, such as drought, with increases in levels of Abscisic Acid (ABA). This stress response allows greater survival rates but results in the plants producing lower seed yield and biomass.
Rasmussen, Casey
core +1 more source

Pre-loading of chlorophyll synthase with tetraprenyl diphosphate is an obligatory step in chlorophyll biosynthesis [PDF]