Results 91 to 100 of about 11,937 (188)

Bisphosphonates used for the treatment of bone disorders inhibit squalene synthase and cholesterol biosynthesis.

Journal of Lipid Research, 1992
Some bisphosphonates used for the treatment of bone disorders are also potent inhibitors of squalene synthase, a critical enzyme for sterol biosynthesis.
D Amin, SA Cornell, SK Gustafson, SJ Needle, JW Ullrich, GE Bilder, MH Perrone   +6 more
doaj   +1 more source

Metabolic engineering of Saccharomyces cerevisiae for enhanced taxadiene production

Microbial Cell Factories
Background Metabolic engineering enables the sustainable and cost-efficient production of complex chemicals. Efficient production of terpenes in Saccharomyces cerevisiae can be achieved by recruiting an intermediate of the mevalonate pathway. The present
Hulya Karaca, Murat Kaya, Handan Açelya Kapkac, Serkan Levent, Yusuf Ozkay, Secil Deniz Ozan, Jens Nielsen, Anastasia Krivoruchko   +7 more
doaj   +1 more source

Virtual Screening for the Selection of New Candidates to Trypanosoma cruzi Farnesyl Pyrophosphate Synthase Inhibitors

, 2018
Chagas disease is a tropical parasitic disease that is caused by Trypanosoma cruzi and causes 12,000 deaths per year, mainly in Latin America. The available drugs for treating have severe limitations, including poor efficacy and high toxicity. One way to
L. Oliveira, J. S. C. Araújo, David Bacelar Costa Júnior, Manoelito C S Junior, A. Júnior, F. H. Leite   +5 more
semanticscholar   +1 more source

Methyl jasmonate induces triterpenoid biosynthesis in Inonotus baumii

Biotechnology & Biotechnological Equipment, 2017
In this work, methyl jasmonate (MeJA), as an exogenous elicitor, was used to investigate the feasibility of enhancing triterpenoid biosynthesis in Inonotus baumii.
Tingting Sun, Li Zou, Linfang Zhang, Jian Zhang, Xutong Wang   +4 more
doaj   +1 more source

Rubber Elongation by Farnesyl Pyrophosphate Synthases Involves a Novel Switch in Enzyme Stereospecificity

Journal of Biological Chemistry, 1989
A prenyltransferase purified from the commercial rubber tree, Hevea brasiliensis, that elongates existing cis-polyisoprene rubber molecules also catalyzes the formation of all trans-farnesyl pyrophosphate (t,t-FPP) from dimethylallyl pyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP).
D R, Light, R A, Lazarus, M S, Dennis
openaire   +2 more sources

Sesquiterpene synthases from Inonotus obliquus: functional characterization and β-farnesene production

Mycology
The medicinal mushroom Inonotus obliquus is renowned for producing a wide array of pharmacologically active terpenoids, yet the enzymatic basis for this diversity remains partially elusive.
Yingce Duan, Jiaxuan Liu, Zheyong Xue, Pengchao Wang, Jie Zhang, Chengwei Liu   +5 more
doaj   +1 more source

Production of the Anticancer Compound Withaferin A from Genetically Transformed Hairy Root Cultures of

Natural Product Communications, 2018
Withanolides (WTDs), well-known medicinally important compounds of Withania somnifera , including the anticancer compound withaferin A (WFA), are biosynthesized from their dedicated precursor squalene.
Zeynab Yousefian, Behnaz Hosseini, Hassan Rezadoost, Javier Palazón, Mohammad Hossein Mirjalili   +4 more
doaj   +1 more source

The role of protein prenylation inhibition through targeting FPPS by zoledronic acid in the prevention of renal fibrosis in rats

Scientific Reports
Renal fibrosis (RF) represents the most widespread pathological condition in chronic kidney disease (CKD). Recently, protein prenylation has been implicated in the fibrosis’s progression. The research examined the renoprotective effect of zoledronic acid
Reham Hussein Mohamed, Dina S. Abdelrahim, Nesma Hussein Abdel Hay, Nesma Mohamed Fawzy, Doaa Karem M. M., Dalia Ahmed Yousef Yehia, Omnia M. AbdelMaksoud, Yomna M. Tamim   +7 more
doaj   +1 more source

Regulation of Steroidal Alkaloid Biosynthesis in Bulbs of Fritillaria thunbergii Miq. By Shading and Potassium Application: Integrating Transcriptomics and Metabolomics Analyses

Biology
Fritillaria thunbergii Miq., a medicinal plant rich in steroidal alkaloids, produces bulbs that clear heat, resolve phlegm, and detoxify. However, excessive yield-oriented cultivation has reduced the number of F.
Jia Liu, Zixuan Zhu, Leran Wang, Qiang Yuan, Honghai Zhu, Xiaoxiao Sheng, Kejie Zhang, Bingbing Liang, Huizhen Jin, Shumin Wang, Wenjun Weng, Hui Wang, Ning Sui   +12 more
doaj   +1 more source

Farnesyl Pyrophosphate Synthase Is an Essential Enzyme in Trypanosoma brucei [PDF]

Journal of Biological Chemistry, 2003
Andrea Montalvetti, Alexis Fernandez, John M. Sanders, Subhash Ghosh, Erin Van Brussel, Eric Oldfield, Roberto Docampo   +6 more
openaire   +1 more source