Results 71 to 80 of about 6,653 (163)

Human Isoprenoid Synthase Enzymes as Therapeutic Targets

Frontiers in Chemistry, 2014
The complex biochemical network known as the mevalonate pathway is responsible for the biosynthesis of all isoprenoids in the human body, which consists of a vast array of metabolites that are vital for proper cellular functions.
Jaeok ePark, Alexios eMatralis, Albert M. Berghuis, Youla S Tsantrizos   +3 more
doaj   +1 more source

Overexpression of the Trichoderma brevicompactum tri5 Gene: Effect on the Expression of the Trichodermin Biosynthetic Genes and on Tomato Seedlings

Toxins, 2011
Trichoderma brevicompactum IBT 40841 produces trichodermin, a trichothecene-type toxin that shares most of the steps of its biosynthesis with harzianum A, another trichothecene produced by several Trichoderma species.
Josefina Aleu, Isidro G. Collado, Santiago Gutierrez, Enrique Monte, Javier Moraga, Monica G. Malmierca, Anamariela Tijerino, Rosa Hermosa, Rosa E. Cardoza   +8 more
doaj   +1 more source

A cDNA Encoding Farnesyl Pyrophosphate Synthase in White Lupin [PDF]

Plant Physiology, 1995
S, Attucci, S M, Aitken, R K, Ibrahim, P J, Gulick   +3 more
openaire   +2 more sources

Mevalonate pathway inhibition reduces bladder cancer metastasis by modulating RhoB protein stability and integrin β1 localization

Communications Biology
The progression and outcome of bladder cancer (BLCA) are critically affected by the propensity of tumor metastasis. Our previous study revealed that activation of the mevalonate (MVA) pathway promoted migration of BLCA cells; however, the exact mechanism
Gang Wang, Tianchen Peng, Liang Chen, Kangping Xiong, Lingao Ju, Kaiyu Qian, Yi Zhang, Yu Xiao, Xinghuan Wang   +8 more
doaj   +1 more source

Bisphosphonates used for the treatment of bone disorders inhibit squalene synthase and cholesterol biosynthesis.

Journal of Lipid Research, 1992
Some bisphosphonates used for the treatment of bone disorders are also potent inhibitors of squalene synthase, a critical enzyme for sterol biosynthesis.
D Amin, SA Cornell, SK Gustafson, SJ Needle, JW Ullrich, GE Bilder, MH Perrone   +6 more
doaj   +1 more source

Functional analysis of Pogostemon cablin farnesyl pyrophosphate synthase gene and its binding transcription factor PcWRKY44 in regulating biosynthesis of patchouli alcohol. [PDF]

Front Plant Sci, 2022
Wang X, Tang Y, Huang H, Wu D, Chen X, Li J, Zheng H, Zhan R, Chen L.   +8 more
europepmc   +1 more source

Metabolic engineering of Saccharomyces cerevisiae for enhanced taxadiene production

Microbial Cell Factories
Background Metabolic engineering enables the sustainable and cost-efficient production of complex chemicals. Efficient production of terpenes in Saccharomyces cerevisiae can be achieved by recruiting an intermediate of the mevalonate pathway. The present
Hulya Karaca, Murat Kaya, Handan Açelya Kapkac, Serkan Levent, Yusuf Ozkay, Secil Deniz Ozan, Jens Nielsen, Anastasia Krivoruchko   +7 more
doaj   +1 more source

Rubber Elongation by Farnesyl Pyrophosphate Synthases Involves a Novel Switch in Enzyme Stereospecificity

Journal of Biological Chemistry, 1989
A prenyltransferase purified from the commercial rubber tree, Hevea brasiliensis, that elongates existing cis-polyisoprene rubber molecules also catalyzes the formation of all trans-farnesyl pyrophosphate (t,t-FPP) from dimethylallyl pyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP).
D R, Light, R A, Lazarus, M S, Dennis
openaire   +2 more sources

Methyl jasmonate induces triterpenoid biosynthesis in Inonotus baumii

Biotechnology & Biotechnological Equipment, 2017
In this work, methyl jasmonate (MeJA), as an exogenous elicitor, was used to investigate the feasibility of enhancing triterpenoid biosynthesis in Inonotus baumii.
Tingting Sun, Li Zou, Linfang Zhang, Jian Zhang, Xutong Wang   +4 more
doaj   +1 more source

Influence of Nutrient (NPK) Factors on Growth, and Pharmacodynamic Component Biosynthesis of Atractylodes chinensis: An Insight on Acetyl-CoA Carboxylase (ACC), 3-Hydroxy-3-Methylglutaryl-CoA Reductase (HMGR), and Farnesyl Pyrophosphate Synthase (FPPS) Signaling Responses. [PDF]

Front Plant Sci, 2022
Sun J, Luo H, Jiang Y, Wang L, Xiao C, Weng L.   +5 more
europepmc   +1 more source