Results 81 to 90 of about 11,937 (188)

Expression of NAC6 Transcription Factor and Its Impact on Carotenoid Metabolism in Postharvest Mango Fruit [PDF]

Shipin Kexue
The NAC transcription factors play an important regulatory role in plant growth and development. In order to explore the impact of NAC6 on carotenoid metabolism in postharvest mango fruit, this study investigated changes in the carotenoid contents as ...
LIANG Minhua, LIANG Ruijin, YANG Zhenfeng, DENG Hongling
doaj   +1 more source

Denosumab Offers Relatively Lower Initial Protection Against Osteoporotic Vertebral Fractures in Treatment‐Naive Patients Compared With Zoledronate

Clinical Pharmacology &Therapeutics, Volume 120, Issue 1, Page 139-149, July 2026.
We compared the initial efficacy of denosumab (Dmab) and zoledronate (ZOL) in treatment‐naive patients with osteoporosis. This cohort study, based on TriNetX data, evaluated the risks of fractures and mortality using Kaplan–Meier survival analyses, with hazard ratios (HRs) and 95% confidence intervals (CIs).
Ko‐Hsiu Lu, Shiow‐Ing Wang, Shun‐Fa Yang   +2 more
wiley   +1 more source

Multi‐Induction Strategies in Crops: Mechanisms, Synergistic Effects, and Sustainable Applications for Enhanced Secondary Metabolite Production

Food Frontiers, Volume 7, Issue 4, July 2026.
This review analyzes single/combined abiotic (light, water, nutrients, hormones) and biotic (microbes, yeast) elicitors regulating signaling, gene expression, and metabolism to boost plant secondary metabolites. It highlights synergistic multielicitor strategies for crop quality and functional foods, while critically addressing current limitations and ...
Yifei Sun, Daoyan Xiao, Xingyue Li, Zhaofei Wang, Maoqin Xia, Chao Song, Hong‐Lei Li   +6 more
wiley   +1 more source

Pharmacophore Mapping of Thienopyrimidine-Based Monophosphonate (ThP-MP) Inhibitors of the Human Farnesyl Pyrophosphate Synthase.

Journal of Medicinal Chemistry, 2017
The human farnesyl pyrophosphate synthase (hFPPS), a key regulatory enzyme in the mevalonate pathway, catalyzes the biosynthesis of the C-15 isoprenoid farnesyl pyrophosphate (FPP).
Jaeok Park, C. Leung, A. Matralis, Cyrus M Lacbay, Michail Tsakos, Guillermo Fernández de Trocóniz, A. Berghuis, Y. Tsantrizos   +7 more
semanticscholar   +1 more source

Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host

Reviews in Medical Virology, Volume 36, Issue 4, July 2026.
ABSTRACT Between mosquitoes and birds, West Nile virus (WNV) is a neurotropic flavivirus, an arthropod‐borne pathogen involved in an enzootic cycle. Additionally, it can infect both people and horses, leading to severe illness. Since 1999, WNV has spread across North and South America, including Mexico and the Caribbean.
E. Cimini, E. Tartaglia, F. Cristofanelli, S. Gili, F. Maggi   +4 more
wiley   +1 more source

Production of borneol, camphor, and bornyl acetate using engineered Saccharomyces cerevisiae

Metabolic Engineering Communications
Microbial production of bicyclic monoterpenes is of great interest because their production primarily utilizes non-sustainable resources. Here, we report an engineered Saccharomyces cerevisiae yeast that produces bicyclic monoterpenes, including borneol,
Masahiro Tominaga, Kazuma Kawakami, Hiro Ogawa, Tomomi Nakamura, Akihiko Kondo, Jun Ishii   +5 more
doaj   +1 more source

Human Isoprenoid Synthase Enzymes as Therapeutic Targets

Frontiers in Chemistry, 2014
The complex biochemical network known as the mevalonate pathway is responsible for the biosynthesis of all isoprenoids in the human body, which consists of a vast array of metabolites that are vital for proper cellular functions.
Jaeok ePark, Alexios eMatralis, Albert M. Berghuis, Youla S Tsantrizos   +3 more
doaj   +1 more source

Overexpression of the Trichoderma brevicompactum tri5 Gene: Effect on the Expression of the Trichodermin Biosynthetic Genes and on Tomato Seedlings

Toxins, 2011
Trichoderma brevicompactum IBT 40841 produces trichodermin, a trichothecene-type toxin that shares most of the steps of its biosynthesis with harzianum A, another trichothecene produced by several Trichoderma species.
Josefina Aleu, Isidro G. Collado, Santiago Gutierrez, Enrique Monte, Javier Moraga, Monica G. Malmierca, Anamariela Tijerino, Rosa Hermosa, Rosa E. Cardoza   +8 more
doaj   +1 more source

A cDNA Encoding Farnesyl Pyrophosphate Synthase in White Lupin [PDF]

Plant Physiology, 1995
S, Attucci, S M, Aitken, R K, Ibrahim, P J, Gulick   +3 more
openaire   +2 more sources

Mevalonate pathway inhibition reduces bladder cancer metastasis by modulating RhoB protein stability and integrin β1 localization

Communications Biology
The progression and outcome of bladder cancer (BLCA) are critically affected by the propensity of tumor metastasis. Our previous study revealed that activation of the mevalonate (MVA) pathway promoted migration of BLCA cells; however, the exact mechanism
Gang Wang, Tianchen Peng, Liang Chen, Kangping Xiong, Lingao Ju, Kaiyu Qian, Yi Zhang, Yu Xiao, Xinghuan Wang   +8 more
doaj   +1 more source