Results 101 to 110 of about 9,308 (197)

C-terminus Proteolysis and Palmitoylation Cooperate for Optimal Plasma Membrane Localization of RasA in Aspergillus fumigatus

Frontiers in Microbiology, 2018
RasA is a major regulator of fungal morphogenesis and virulence in Aspergillus fumigatus. The proper localization of RasA to the plasma membrane is essential for the formation of invasive hyphae during infection.
Qusai Al Abdallah, Adela Martin-Vicente, Ana Camila Oliveira Souza, Wenbo Ge, Jarrod R. Fortwendel   +4 more
doaj   +1 more source

Wirkung des Farnesyltransferaseinhibitors BZA-5B auf das Wachstum humaner Bronchialkarzinomzellen [PDF]

, 2005
Ras-Mutationen werden in zirka 30% aller malignen Tumoren nachgewiesen. Es sind drei verschiedene ras-Gene bekannt, nämlich H-, K- und N-ras. Am häufigsten wird eine Mutation des K-ras-Gens nachgewiesen, dieses macht beim Bronchialkarzinom mehr als 95 ...
Langhans, Andrea Gabriele, Schuermann, Marcus (Prof. Dr.)   +1 more
core   +1 more source

Thematic review series: Lipid Posttranslational Modifications. Fighting parasitic disease by blocking protein farnesylation

Journal of Lipid Research, 2006
Protein farnesylation is a form of posttranslational modification that occurs in most, if not all, eukaryotic cells. Inhibitors of protein farnesyltransferase (PFTIs) have been developed as anticancer chemotherapeutic agents.
Richard T. Eastman, Frederick S. Buckner, Kohei Yokoyama, Michael H. Gelb, Wesley C. Van Voorhis   +4 more
doaj   +1 more source

Exploration of Aspergillus fumigatus Ras pathways for novel antifungal drug targets

Frontiers in Microbiology, 2015
Ras pathway signaling is a critical virulence determinant for pathogenic fungi. Localization of Ras to the plasma membrane (PM) is required for Ras network interactions supporting fungal growth and virulence. For example, loss of A.
Qusai eAl Abdallah, Jarrod R Fortwendel
doaj   +1 more source

The truncated prelamin A in Hutchinson-Gilford progeria syndrome alters segregation of A-type and B-type lamin homopolymers. [PDF]

, 2006
Hutchinson-Gilford progeria syndrome (HGPS) is a dominant autosomal premature aging syndrome caused by the expression of a truncated prelamin A designated progerin.
Buendia, Brigitte, Coppey-Moisan, Maïté, Courvalin, Jean-Claude, Delbarre, Erwan, Gaillard, Claire, Tramier, Marc   +5 more
core   +1 more source

New target therapies in hepatocellular carcinoma : a study in cell lines in culture [PDF]

, 2010
Trabalho final do 6º Ano Médico com vista à atribuição do grau de Mestre no âmbito do Ciclo de Estudos de Mestrado Integrado em MedicinaO carcinoma hepatocelular é uma doença complexa e devastadora que se mantém resistente à quimioterapia convencional. O
Araújo, Ana Maria Faria
core  

Characterisation of an alternative splice variant of LKB1

, 2010
The LKB1 protein kinase has previously been implicated in a number of major physiological processes including cell proliferation, polarity and energy metabolism.
Denison, Fiona Clare, Denison, Fiona Clare   +1 more
core   +1 more source

Weaving a pattern from disparate threads: lamin function in nuclear assembly and DNA replication [PDF]

, 1994
The major residual structure that remains associated with the nuclear envelope following extraction of isolated nuclei or oocyte germinal vesicles with non-ionic detergents, nucleases and high salt is the lamina (Fawcett, 1966; Aaronson and Blobel ...
Bridger, JM, Cox, LS, Hutchison, CJ, Kill, IR   +3 more
core  

ISEV2025 Abstract Book

Journal of Extracellular Vesicles, Volume 14, Issue S1, October 2025.
wiley   +1 more source

Artificial Multidomain Ribosomally Synthesized and Post-translationally Modified Peptide Enzymes for Farnesylated Peptide Library Generation. [PDF]

ACS Synth Biol
Lacerna N, Schmidt EW.
europepmc   +1 more source