Results 1 to 10 of about 3,218 (202)

Development of an image-based screening system for inhibitors of the plastidial MEP pathway and of protein geranylgeranylation [v2; ref status: indexed, http://f1000r.es/5p9]

F1000Research, 2015
In a preceding study we have recently established an in vivo visualization system for the geranylgeranylation of proteins in a stably transformed tobacco BY-2 cell line, which involves expressing a dexamethasone-inducible GFP fused to the prenylable ...
Michael Hartmann, Elisabet Gas-Pascual, Andrea Hemmerlin, Michel Rohmer, Thomas J. Bach   +4 more
doaj   +2 more sources

Identification of Geranylgeranyl-Modified Proteins in HeLa Cells [PDF]

Science, 1990
Previous studies have shown that animal cells contain isoprenoid-modified proteins and that one of these proteins, lamin B, contains a thioether-linked farnesyl group that is attached to cysteine. In the present study, a novel isoprenoid-modification was identified by labeling HeLa cells with [ 3 H]mevalonic acid ...
C C, Farnsworth, M H, Gelb, J A, Glomset
openaire   +2 more sources

Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: implication for therapy. [PDF]

PLoS ONE, 2012
The cancer killing efficacy of standard chemotherapeutic agents such as cisplatin (CDDP) is limited by their side effects to normal tissues. Therefore, research efforts optimizing the safety and efficacy of those agents are clinically relevant.
Yandong Shi, Emanuela Felley-Bosco, Thomas M Marti, Rolf A Stahel   +3 more
doaj   +1 more source

Zoledronic acid inhibits TSC2-null cell tumor growth via RhoA/YAP signaling pathway in mouse models of lymphangioleiomyomatosis

Cancer Cell International, 2020
Background This study is to investigate the effects of zoledronic acid (ZA) on TSC2-null cell proliferation and on the tumor progression and recurrence in mouse models of lymphangioleiomyomatosis (LAM).
Dandan Zhao, Jing Wu, Yinjuan Zhao, Wei Shao, Qi Cheng, Xiaoyan Shao, Xianwen Yuan, Juan Ye, Jianpu Gao, Meiling Jin, Chaojun Li, Xiaolin Chen, Yue Zhao, Bin Xue   +13 more
doaj   +1 more source

RABGGTB plays a critical role in ALS pathogenesis

Brain Research Bulletin
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with unknown causes, which mainly affects motor neurons in the anterior horn of the spinal cord, brain stem, and cerebral cortex, also known as motor neuron disease.
Haiyang Ma, Jia Huo, Cheng Xin, Jing Yang, Qi Liu, Hui Dong, Rui Li, Yaling Liu   +7 more
doaj   +1 more source

Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells

BMC Cancer, 2006
Background Nitrogen-containing bisphosphonates (N-BPs) have been designed to inhibit osteoclast-mediated bone resorption. However, it is now accepted that part of their anti-tumor activities is related to interference with the mevalonate pathway. Methods
Weinbaum Carolyn, Faye JC, Lajoie-Mazenc I, Pradines A, Thoulouzan M, Goffinet M, Séronie-Vivien S   +6 more
doaj   +1 more source

Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy

Cell Reports, 2015
Balance between cell growth and proliferation determines cell size homeostasis, but little is known about how metabolic pathways are involved in the maintenance of this balance.
Teemu P. Miettinen, Mikael Björklund
doaj   +1 more source

Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11.

PLoS Biology, 2014
Vesicular trafficking plays a key role in tuning the activity of Notch signaling. Here, we describe a novel and conserved Rab geranylgeranyltransferase (RabGGT)-α-like subunit that is required for Notch signaling-mediated lateral inhibition and cell fate
Wu-Lin Charng, Shinya Yamamoto, Manish Jaiswal, Vafa Bayat, Bo Xiong, Ke Zhang, Hector Sandoval, Gabriela David, Stephen Gibbs, Hsiang-Chih Lu, Kuchuan Chen, Nikos Giagtzoglou, Hugo J Bellen   +12 more
doaj   +1 more source

Metabolic Stress Induces Caspase-3 Mediated Degradation and Inactivation of Farnesyl and Geranylgeranyl Transferase Activities in Pancreatic β-Cells

Cellular Physiology and Biochemistry, 2016
Background/Aims: At least 300 prenylated proteins are identified in the human genome; the majority of which partake in a variety of cellular processes including growth, differentiation, cytoskeletal organization/dynamics and vesicle trafficking. Aberrant
Rajakrishnan Veluthakal, Daleep K. Arora, Marc L. Goalstone, Renu A. Kowluru, Anjaneyulu Kowluru   +4 more
doaj   +1 more source

Inhibition of protein geranylgeranylation and farnesylation protects against graft-versus-host disease via effects on CD4 effector T cells

Haematologica, 2013
Despite advances in immunosuppressive regimens, acute graft-versus-host disease remains a frequent complication of allogeneic hematopoietic cell transplantation.
Anne-Kathrin Hechinger, Kristina Maas, Christoph Dürr, Franziska Leonhardt, Gabriele Prinz, Reinhard Marks, Ulrike Gerlach, Maike Hofmann, Paul Fisch, Jürgen Finke, Hanspeter Pircher, Robert Zeiser   +11 more
doaj   +1 more source