Lack of Prenylated Proteins, Autophagy Impairment and Apoptosis in SH-SY5Y Neuronal Cell Model of Mevalonate Kinase Deficiency [PDF]
Cellular Physiology and Biochemistry, 2017 Background/Aims: Mevalonate Kinase Deficiency (MKD), is a hereditary disease due to mutations in mevalonate kinase gene (MVK). MKD has heterogeneous clinical phenotypes: the correlation between MVK mutations and MKD clinical phenotype is still to be ...
Paola Maura Tricarico +4 more
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Frontiers in Immunology, 2021 Precisely controlled lymphocyte migration is critically required for immune surveillance and successful immune responses. Lymphocyte migration is strictly regulated by chemokines and chemokine receptors.
Gregory Swan +11 more
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The structural basis for synergistic inhibition of geranylgeranyl diphosphate synthase with stereoisomeric triazole bisphosphonates [PDF]
Structural DynamicsSeveral incurable cancers are characterized by abnormal protein production and secretion. A prime example being multiple myeloma and its excessive production of non-functional antibodies (M protein).
Andrew Pham +2 more
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Upregulated GBP2 exacerbates Parkinson's disease pathogenesis by impairing NIX-dependent mitophagy [PDF]
Redox BiologyParkinson's disease (PD), characterized by dopaminergic neuron loss, still lacks disease-modifying therapies due to incompletely understood mechanisms. Guanylate-binding proteins (GBPs) are well-known immune regulators, but their roles in PD are largely ...
Wenqi Cui, Tianlu Wang, Juan Feng
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Zoledronic acid treatment impairs protein geranyl-geranylation for biological effects in prostatic cells [PDF]
BMC Cancer, 2006 Background Nitrogen-containing bisphosphonates (N-BPs) have been designed to inhibit osteoclast-mediated bone resorption. However, it is now accepted that part of their anti-tumor activities is related to interference with the mevalonate pathway. Methods
Weinbaum Carolyn +6 more
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Geranylgeranyl diphosphate synthase: Role in human health, disease and potential therapeutic target [PDF]
Clinical and Translational Medicine, 2023 Geranylgeranyl diphosphate synthase (GGDPS), an enzyme in the isoprenoid biosynthesis pathway, is responsible for the production of geranylgeranyl pyrophosphate (GGPP).
Molly E. Muehlebach, Sarah A. Holstein
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Differential requirements of protein geranylgeranylation for the virulence of human pathogenic fungi
Virulence, 2019 Protein prenylation is a crucial post-translational modification largely mediated by two heterodimeric enzyme complexes, farnesyltransferase and geranylgeranyltransferase type-I (GGTase-I), each composed of a shared α-subunit and a unique β-subunit ...
Ana Camila Oliveira Souza +9 more
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Journal of Pharmacological Sciences, 2015 Collagen I is the main component of extracellular matrix in cardiac fibrosis. Our previous studies have reported inhibition of farnesylpyrophosphate synthase prevents angiotensin II-induced cardiac fibrosis, while the exact molecular mechanism was still ...
Yang Ye +6 more
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Updates on protein-prenylation and associated inherited retinopathies [PDF]
Frontiers in OphthalmologyMembrane-anchored proteins play critical roles in cell signaling, cellular architecture, and membrane biology. Hydrophilic proteins are post-translationally modified by a diverse range of lipid molecules such as phospholipids ...
Sudhat Ashok +3 more
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The effects of geranylgeranyl diphosphate synthase inhibitor treatment on osteoblast biology and application in a conditioned media model of myeloma bone disease [PDF]
Bone ReportsMyeloma bone disease (MBD) is characterized by tumor-induced osteoclast activation with concomitant suppression of osteoblast activity. Nitrogen bisphosphonates (NBPs), including zoledronic acid (ZA), are a mainstay of MBD treatment, due to their anti ...
Molly E. Muehlebach, Sarah A. Holstein
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