Results 11 to 20 of about 5,118 (209)

Thematic review series: Lipid Posttranslational Modifications. Geranylgeranylation of Rab GTPases

Journal of Lipid Research, 2006
Rab GTPases require special machinery for protein prenylation, which include Rab escort protein (REP) and Rab geranylgeranyl transferase (RGGT). The current model of Rab geranylgeranylation proposes that REP binds Rab and presents it to RGGT.
Ka Fai Leung, Rudi Baron, Miguel C. Seabra   +2 more
doaj   +3 more sources

Liposomal simvastatin potentiates intranasal H1N1 influenza subunit vaccine via increasing transcytosis of antigen and submucosal dendritic cell recruitment [PDF]

Acta Pharmaceutica Sinica B
Intranasal vaccines specifically eliciting mucosal immunity in the upper respiratory tract have shown advantages in protecting against respiratory virus invasion.
Afeng Yang, Chen Zhang, Aihua Wu, Jiaojiao Xu, Hongzheng Lin, Zhe Li, Tingting Li, Yunlu Li, Ningshao Xia, Xunlong Shi, Tianying Zhang, Wei Lu   +11 more
doaj   +2 more sources

Mevalonate pathway inhibition reduces bladder cancer metastasis by modulating RhoB protein stability and integrin β1 localization [PDF]

Communications Biology
The progression and outcome of bladder cancer (BLCA) are critically affected by the propensity of tumor metastasis. Our previous study revealed that activation of the mevalonate (MVA) pathway promoted migration of BLCA cells; however, the exact mechanism
Gang Wang, Tianchen Peng, Liang Chen, Kangping Xiong, Lingao Ju, Kaiyu Qian, Yi Zhang, Yu Xiao, Xinghuan Wang   +8 more
doaj   +2 more sources

Geranylgeranylated SCFFBXO10 regulates selective outer mitochondrial membrane proteostasis and function [PDF]

Cell Reports
Summary: Compartment-specific cellular membrane protein turnover is not well understood. We show that FBXO10, the interchangeable component of the cullin-RING-ligase 1 complex, undergoes lipid modification with geranylgeranyl isoprenoid at cysteine953 ...
Sameer Ahmed Bhat, Zahra Vasi, Liping Jiang, Shruthi Selvaraj, Rachel Ferguson, Sanaz Salarvand, Anish Gudur, Ritika Adhikari, Veronica Castillo, Hagar Ismail, Avantika Dhabaria, Beatrix Ueberheide, Shafi Kuchay   +12 more
doaj   +2 more sources

Statin-induced increases in atrophy gene expression occur independently of changes in PGC1α protein and mitochondrial content [PDF]

, 2015
One serious side effect of statin drugs is skeletal muscle myopathy. Although the mechanism(s) responsible for statin myopathy remains to be fully determined, an increase in muscle atrophy gene expression and changes in mitochondrial content and/or ...
Goodman, Craig, Lee-Young, RS, McConell, Glenn, Pol, D, Russell, AP, Snow, RJ, Zacharewicz, E   +6 more
core   +15 more sources

Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase [PDF]

Journal of Biological Chemistry, 2009
Rab geranylgeranyl transferase (RGGT) catalyzes the post-translational geranylgeranyl (GG) modification of (usually) two C-terminal cysteines in Rab GTPases. Here we studied the mechanism of the Rab geranylgeranylation reaction by bisphosphonate analogs in which one phosphonate group is replaced by a carboxylate (phosphonocarboxylate, PC).
Baron, Rudi A., Tavaré, Richard, Figueiredo, Ana C., Błazewska, Katarzyna M., Kashemirov, Boris A., McKenna, Charles E., Ebetino, Frank H., Taylor, Adam, Rogers, MIchael J., Coxon, Fraser P., C Seabra, Miguel   +10 more
openaire   +6 more sources

GGPS1 Promoter Variant (rs3806394) Is Associated With Larger Simple Renal Cysts via Reduced GGPPS Expression. [PDF]

Hum Mutat
Objective We are aimed at investigating the association between the size of simple renal cyst (SRC) and the expression of geranylgeranyl pyrophosphate synthase (GGPPS), which can induce renal cyst formation after its deletion. Methods Seventy‐seven patients who received renal cyst decortication were enrolled.
Wang K, Tang T, Xu T, Chen Z, Gou L, Wang Y, Wang D, Wu J, Wang X, Xue B, Xu X.   +10 more
europepmc   +2 more sources

GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary. [PDF]

PLoS Genetics, 2017
Folliculogenesis is a progressive and highly regulated process, which is essential to provide ova for later reproductive life, requires the bidirectional communication between the oocyte and granulosa cells.
Chen Jiang, Fan Diao, Yong-Juan Sang, Na Xu, Rui-Lou Zhu, Xiu-Xing Wang, Zhong Chen, Wei-Wei Tao, Bing Yao, Hai-Xiang Sun, Xing-Xu Huang, Bin Xue, Chao-Jun Li   +12 more
doaj   +1 more source

Design and Evaluation of Bivalent K-Ras Inhibitors That Target the CAAX Binding Site and the Acidic Surface of Farnesyltransferase and Geranylgeranyltransferase I. [PDF]

Chemistry
Chemical inhibition of K‐Ras posttranslational prenylation represents a promising strategy against aggressive cancers. A structure‐based design produces piperidine‐based peptidomimetics conjugated to cationic modules, effectively inhibiting FTase and GGTase I at single‐digit nanomolar concentrations.
Horiuchi N, Omer R, Sugino F, Ogino N, Inoue Y, Aslamuzzaman K, Suzuki T, Sebti SM, Ohkanda J.   +8 more
europepmc   +2 more sources

CAAX Geranylgeranyl Transferase Transfers Farnesyl as Efficiently as Geranylgeranyl to RhoB [PDF]

Journal of Biological Chemistry, 1995
RhoB, a small GTP-binding protein, was shown previously to contain farnesyl (C-15) as well as geranylgeranyl (C-20) groups (Adamson, P., Marshall, C. J., Hall, A., and Tilbrook, P. A. (1992) J. Biol. Chem. 267, 20033-20038). The COOH-terminal sequence of the protein is CCKVL.
S A, Armstrong, V C, Hannah, J L, Goldstein, M S, Brown   +3 more
openaire   +2 more sources