Journal of Pharmacological Sciences, 2015 Collagen I is the main component of extracellular matrix in cardiac fibrosis. Our previous studies have reported inhibition of farnesylpyrophosphate synthase prevents angiotensin II-induced cardiac fibrosis, while the exact molecular mechanism was still ...
, Xue Lv, Mei-Hui Wang
exaly +4 more sources
Differential requirements of protein geranylgeranylation for the virulence of human pathogenic fungi
Virulence, 2019 Protein prenylation is a crucial post-translational modification largely mediated by two heterodimeric enzyme complexes, farnesyltransferase and geranylgeranyltransferase type-I (GGTase-I), each composed of a shared α-subunit and a unique β-subunit ...
Ana Camila Oliveira Souza +2 more
exaly +3 more sources
Frontiers in Immunology, 2021 Precisely controlled lymphocyte migration is critically required for immune surveillance and successful immune responses. Lymphocyte migration is strictly regulated by chemokines and chemokine receptors.
Gregory Swan +2 more
exaly +3 more sources
GGPP-Mediated Protein Geranylgeranylation in Oocyte Is Essential for the Establishment of Oocyte-Granulosa Cell Communication and Primary-Secondary Follicle Transition in Mouse Ovary. [PDF]
PLoS Genetics, 2017 Folliculogenesis is a progressive and highly regulated process, which is essential to provide ova for later reproductive life, requires the bidirectional communication between the oocyte and granulosa cells.
Chen Jiang +12 more
doaj +2 more sources
Upregulated GBP2 exacerbates Parkinson's disease pathogenesis by impairing NIX-dependent mitophagy [PDF]
Redox BiologyParkinson's disease (PD), characterized by dopaminergic neuron loss, still lacks disease-modifying therapies due to incompletely understood mechanisms. Guanylate-binding proteins (GBPs) are well-known immune regulators, but their roles in PD are largely ...
Wenqi Cui, Tianlu Wang, Juan Feng
doaj +2 more sources
The structural basis for synergistic inhibition of geranylgeranyl diphosphate synthase with stereoisomeric triazole bisphosphonates [PDF]
Structural DynamicsSeveral incurable cancers are characterized by abnormal protein production and secretion. A prime example being multiple myeloma and its excessive production of non-functional antibodies (M protein).
Andrew Pham +2 more
doaj +5 more sources
Inhibition of Geranylgeranyl Transferase-I Decreases Cell Viability of HTLV-1-Transformed Cells
Viruses, 2011 Human T-cell leukemia virus type-1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL), an aggressive and highly chemoresistant malignancy.
Cynthia A. Pise-Masison +5 more
doaj +2 more sources
The effects of geranylgeranyl diphosphate synthase inhibitor treatment on osteoblast biology and application in a conditioned media model of myeloma bone disease [PDF]
Bone ReportsMyeloma bone disease (MBD) is characterized by tumor-induced osteoclast activation with concomitant suppression of osteoblast activity. Nitrogen bisphosphonates (NBPs), including zoledronic acid (ZA), are a mainstay of MBD treatment, due to their anti ...
Molly E. Muehlebach, Sarah A. Holstein
doaj +2 more sources
Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors
Molecules, 2017 The enzyme geranylgeranyl diphosphate synthase (GGDPS) catalyzes the synthesis of the 20-carbon isoprenoid geranylgeranyl diphosphate (GGPP). GGPP is the isoprenoid donor for protein geranylgeranylation reactions catalyzed by the enzymes geranylgeranyl ...
Staci L. Haney +3 more
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Updates on protein-prenylation and associated inherited retinopathies [PDF]
Frontiers in OphthalmologyMembrane-anchored proteins play critical roles in cell signaling, cellular architecture, and membrane biology. Hydrophilic proteins are post-translationally modified by a diverse range of lipid molecules such as phospholipids ...
Sudhat Ashok +3 more
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