Results 21 to 30 of about 5,118 (209)

Geranylgeranyl Switching Regulates [PDF]

Structure, 2003
AbstractRab GTPases, key regulators of membrane targeting and fusion, require the covalent attachment of geranylgeranyl lipids to their C terminus for function. To elucidate the role of lipid in Rab recycling, we have determined the crystal structure of Rab guanine nucleotide dissociation inhibitor (αGDI) in complex with a geranylgeranyl (GG) ligand ...
An, Yu, Shao, Ying, Alory, Christelle, Matteson, Jeanne, Sakisaka, Toshiaki, Chen, Wei, Gibbs, Richard A, Wilson, Ian A, Balch, William E   +8 more
openaire   +1 more source

Inhibition of Geranylgeranyl Transferase-I Decreases Cell Viability of HTLV-1-Transformed Cells

Viruses, 2011
Human T-cell leukemia virus type-1 (HTLV-1) is the etiological agent of adult T-cell leukemia (ATL), an aggressive and highly chemoresistant malignancy.
Cynthia A. Pise-Masison, Kyung-Jin Jung, John N. Brady, Claudio Fenizia, Katherine M. McKinnon, Dustin C. Edwards   +5 more
doaj   +1 more source

The effector domain of Rab6, plus a highly hydrophobic C terminus, is required for Golgi apparatus localization [PDF]

, 1994
C-terminal lipid modifications are essential for the interaction of Ras-related proteins with membranes. While all Ras proteins are farnesylated and some palmitoylated, the majority of other Ras-related proteins are geranylgeranylated.
Beranger, F., Paterson, H., Powers, S., de Gunzburg, J., Hancock, J. F.   +4 more
core   +1 more source

Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome

Journal of Lipid Research, 2009
Hutchinson-Gilford progeria syndrome (HGPS) is caused by the synthesis of a truncated prelamin A, commonly called progerin, that contains a carboxyl-terminal farnesyl lipid anchor.
Brandon S.J. Davies, Shao H. Yang, Emily Farber, Roger Lee, Suzanne B. Buck, Douglas A. Andres, H. Peter Spielmann, Brian J. Agnew, Fuyuhiko Tamanoi, Loren G. Fong, Stephen G. Young   +10 more
doaj   +1 more source

Recent Advances in the Development of Mammalian Geranylgeranyl Diphosphate Synthase Inhibitors

Molecules, 2017
The enzyme geranylgeranyl diphosphate synthase (GGDPS) catalyzes the synthesis of the 20-carbon isoprenoid geranylgeranyl diphosphate (GGPP). GGPP is the isoprenoid donor for protein geranylgeranylation reactions catalyzed by the enzymes geranylgeranyl ...
Staci L. Haney, Veronica S. Wills, David F. Wiemer, Sarah A. Holstein   +3 more
doaj   +1 more source

Statins and protein prenylation in cancer cell biology and therapy [PDF]

, 2012
El pdf del artículo es la versión post-print.The use of statins has scaled up to become one of the most prescribed medicines in the world and have been very useful in the manegement of cardiovascular diseases and related mortality.
Fernández-Checa, José C., García-Ruiz, Carmen, Morales, Albert   +2 more
core   +2 more sources

Synthesis of the 6-Substituted Imidazo[1,2-a]Pyridine-3-yl-2- Phosphonopropionic Acids as Potential Inhibitors of Rab Geranylgeranyl Transferase

Frontiers in Chemistry, 2021
Twelve phosphonopropionates derived from 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid (3-IPEHPC) were synthesized and evaluated for their activity as inhibitors of protein geranylgeranylation.
Damian Kusy, Aleksandra Marchwicka, Joanna Małolepsza, Katarzyna Justyna, Katarzyna Justyna, Edyta Gendaszewska-Darmach, Katarzyna Magdalena Błażewska   +6 more
doaj   +1 more source

Inhibition of the mevalonate pathway augments the activity of pitavastatin against ovarian cancer cells [PDF]

, 2017
Only 40% of patients with advanced ovarian cancer survive more than 5 years. We have previously shown that pitavastatin induces regression of ovarian cancer xenografts in mice.
Abdullah, MI, Abed, MN, Richardson, A
core   +1 more source

Geranylgeranyl pyrophosphate depletion by statins compromises skeletal muscle insulin sensitivity

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Statins are widely prescribed cholesterol‐lowering drugs but have been shown to increase the risk of type 2 diabetes mellitus. However, the molecular mechanisms underlying the diabetogenic effect of statins are still not fully understood ...
Lai Wang, Zuguo Zheng, Lijun Zhu, Lingchang Meng, Hanling Liu, Keke Wang, Jun Chen, Ping Li, Hua Yang   +8 more
doaj   +1 more source

Statins and the vasculopathy of systemic sclerosis: potential therapeutic agents? [PDF]

, 2006
It has been postulated that endothelial cell injury is the initiating event in the pathogenesis of systemic sclerosis, causing attraction, attachment, migration and infiltration of activated T-cells and subsequent production of cytokines and growth ...
Derk, Chris T., Jimenez, Sergio A.
core   +2 more sources