Results 21 to 30 of about 3,218 (202)

Lysophosphatidylcholine Increases Na+/Ca2+ Exchanger Expression via RhoB-Geranylgeranylation in H9c2 Cells

Journal of Pharmacological Sciences, 2009
The expression levels of the Na+/Ca2+ exchanger type 1 (NCX1) change under various cardiac pathophysiological conditions, but the mechanism is unknown. We previously demonstrated that lysophosphatidylcholine (LPC) increased NCX1 expression by activating ...
Sachiko Maeda, Kazuho Sakamoto, Isao Matsuoka, Takahiro Iwamoto, Junko Kimura   +4 more
doaj   +2 more sources

Liposomal simvastatin potentiates intranasal H1N1 influenza subunit vaccine via increasing transcytosis of antigen and submucosal dendritic cell recruitment [PDF]

Acta Pharmaceutica Sinica B
Intranasal vaccines specifically eliciting mucosal immunity in the upper respiratory tract have shown advantages in protecting against respiratory virus invasion.
Afeng Yang, Chen Zhang, Aihua Wu, Jiaojiao Xu, Hongzheng Lin, Zhe Li, Tingting Li, Yunlu Li, Ningshao Xia, Xunlong Shi, Tianying Zhang, Wei Lu   +11 more
doaj   +2 more sources

Development of an image-based screening system for inhibitors of the plastidial MEP pathway and of protein geranylgeranylation [v1; ref status: indexed, http://f1000r.es/4vt]

F1000Research, 2015
We have recently established an in vivo visualization system for the geranylgeranylation of proteins in a stably transformed tobacco BY-2 cell line, which involves expressing a dexamethasone-inducible GFP fused to the prenylable, carboxy-terminal basic ...
Michael Hartmann, Elisabet Gas-Pascual, Andrea Hemmerlin, Michel Rohmer, Thomas J. Bach   +4 more
doaj   +2 more sources

Synergistic Effect of Geranylgeranyltransferase Inhibitor, GGTI, and Docetaxel on the Growth of Prostate Cancer Cells [PDF]

Prostate Cancer, 2012
Most advanced prostate cancers progress to castration resistant prostate cancer (CRPC) after a few years of androgen deprivation therapy and the prognosis of patients with CRPC is poor.
Bin Han, Naohiro Fujimoto, Mizuki Kobayashi, Tetsuro Matsumoto   +3 more
doaj   +2 more sources

Mevalonate pathway inhibition reduces bladder cancer metastasis by modulating RhoB protein stability and integrin β1 localization [PDF]

Communications Biology
The progression and outcome of bladder cancer (BLCA) are critically affected by the propensity of tumor metastasis. Our previous study revealed that activation of the mevalonate (MVA) pathway promoted migration of BLCA cells; however, the exact mechanism
Gang Wang, Tianchen Peng, Liang Chen, Kangping Xiong, Lingao Ju, Kaiyu Qian, Yi Zhang, Yu Xiao, Xinghuan Wang   +8 more
doaj   +2 more sources

Geranylgeranylated SCFFBXO10 regulates selective outer mitochondrial membrane proteostasis and function [PDF]

Cell Reports
Summary: Compartment-specific cellular membrane protein turnover is not well understood. We show that FBXO10, the interchangeable component of the cullin-RING-ligase 1 complex, undergoes lipid modification with geranylgeranyl isoprenoid at cysteine953 ...
Sameer Ahmed Bhat, Zahra Vasi, Liping Jiang, Shruthi Selvaraj, Rachel Ferguson, Sanaz Salarvand, Anish Gudur, Ritika Adhikari, Veronica Castillo, Hagar Ismail, Avantika Dhabaria, Beatrix Ueberheide, Shafi Kuchay   +12 more
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Inhibition of Rho and Rac geranylgeranylation by atorvastatin is critical for preservation of endothelial junction integrity.

PLoS ONE, 2013
BackgroundSmall GTPases (guanosine triphosphate, GTP) are involved in many critical cellular processes, including inflammation, proliferation, and migration.
Hongbing Xiao, Xiong Qin, Ding Ping, Keqiang Zuo   +3 more
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Phosphonocarboxylates Inhibit the Second Geranylgeranyl Addition by Rab Geranylgeranyl Transferase [PDF]

Journal of Biological Chemistry, 2009
Rab geranylgeranyl transferase (RGGT) catalyzes the post-translational geranylgeranyl (GG) modification of (usually) two C-terminal cysteines in Rab GTPases. Here we studied the mechanism of the Rab geranylgeranylation reaction by bisphosphonate analogs in which one phosphonate group is replaced by a carboxylate (phosphonocarboxylate, PC).
Baron, Rudi A., Tavaré, Richard, Figueiredo, Ana C., Błazewska, Katarzyna M., Kashemirov, Boris A., McKenna, Charles E., Ebetino, Frank H., Taylor, Adam, Rogers, MIchael J., Coxon, Fraser P., C Seabra, Miguel   +10 more
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CAAX Geranylgeranyl Transferase Transfers Farnesyl as Efficiently as Geranylgeranyl to RhoB [PDF]

Journal of Biological Chemistry, 1995
RhoB, a small GTP-binding protein, was shown previously to contain farnesyl (C-15) as well as geranylgeranyl (C-20) groups (Adamson, P., Marshall, C. J., Hall, A., and Tilbrook, P. A. (1992) J. Biol. Chem. 267, 20033-20038). The COOH-terminal sequence of the protein is CCKVL.
S A, Armstrong, V C, Hannah, J L, Goldstein, M S, Brown   +3 more
openaire   +2 more sources

Geranylgeranyl diphosphate synthase: Role in human health, disease and potential therapeutic target

Clinical and Translational Medicine, 2023
Geranylgeranyl diphosphate synthase (GGDPS), an enzyme in the isoprenoid biosynthesis pathway, is responsible for the production of geranylgeranyl pyrophosphate (GGPP).
Molly E. Muehlebach, Sarah A. Holstein
doaj   +1 more source