Results 41 to 50 of about 3,218 (202)

Inhibition of geranylgeranylation mediates sensitivity to CHOP-induced cell death of DLBCL cell lines.

, 2011
Prenylation is a post-translational hydrophobic modification of proteins, important for their membrane localization and biological function. The use of inhibitors of prenylation has proven to be a useful tool in the activation of apoptotic pathways in ...
Fjordén, Karin, Drott, Kristina, Malin Ageberg, Johan Linderoth, Lindén, Ola, Linderoth, Johan, Jerkeman, Mats, Ola Lindén, Mats Jerkeman, Kristina Drott, Ageberg, Malin, Karin Rydström   +11 more
core   +2 more sources

The role of lipid post-translational modification in plant developmental processes

Frontiers in Plant Science, 2014
Most eukaryotic proteins are post-translationally modified, and modification has profound effects on protein function. One key modification is the attachment of a lipid group to certain amino acids; this typically facilitates subcellular targeting ...
Mark Paul Running
doaj   +1 more source

A quantitative method to measure geranylgeranyl diphosphate (GGPP) and geranylgeranyl monophosphate (GGP) in tomato (Solanum lycopersicum) fruit

Plant Methods, 2023
Abstract Background Isoprenoids are a very large class of metabolites playing a key role in plant physiological processes such as growth, stress resistance, fruit flavor, and color. In chloroplasts and chromoplasts, the diterpene compound geranylgeranyl diphosphate (GGPP) is the metabolic ...
Zita, Wayne, Shanmugabalaji, Venkatasalam, Ezquerro-Urzanqui, Miguel, Kessler, Felix, Glauser, Gaetan, RODRIGUEZ-CONCEPCION, Manuel   +5 more
openaire   +5 more sources

Probing the druggability of membrane-bound Rab5 by molecular dynamics simulations

Journal of Enzyme Inhibition and Medicinal Chemistry, 2017
Rab5 is a small GTPase and a key regulator in early endosomal trafficking. Rab5 and its effectors are involved in a large number of infectious diseases and certain types of cancer.
Eileen Edler, Matthias Stein
doaj   +1 more source

Lack of Prenylated Proteins, Autophagy Impairment and Apoptosis in SH-SY5Y Neuronal Cell Model of Mevalonate Kinase Deficiency

Cellular Physiology and Biochemistry, 2017
Background/Aims: Mevalonate Kinase Deficiency (MKD), is a hereditary disease due to mutations in mevalonate kinase gene (MVK). MKD has heterogeneous clinical phenotypes: the correlation between MVK mutations and MKD clinical phenotype is still to be ...
Paola Maura Tricarico, Alessandra Romeo, Rossella Gratton, Sergio Crovella, Fulvio Celsi   +4 more
doaj   +1 more source

Mevalonate metabolism-dependent protein geranylgeranylation regulates thymocyte egress

, 2020
Thymocyte egress is a critical determinant of T cell homeostasis and adaptive immunity. Despite the roles of G protein–coupled receptors in thymocyte emigration, the downstream signaling mechanism remains poorly defined.
Neale, G., Bergö, Martin O.,, Du, X., Guy, C., Dhungana, Y., Zeng, H., Chi, H., Liu, S.   +7 more
core   +1 more source

Involvement of geranylgeranylation of Rho and Rac GTPases in adipogenic and RANKL expression, which was inhibited by simvastatin [PDF]

, 2013
Simvastatin suppresses myoblast differentiation via inhibition of Rac GTPase, which is involved in the mevalonic acid pathway that produces cholesterol.
Ohara-Nemoto, Y., T. Miyazaki, Miyazaki, T., T. T. Baba, Nemoto, T. K, Baba, T. T, T. K. Nemoto, Y. Ohara‐Nemoto   +7 more
core   +1 more source

The effect of MEP pathway and other inhibitors on the intracellular localization of a plasma membrane-targeted, isoprenylable GFP reporter protein in tobacco BY-2 cells [v2; ref status: indexed, http://f1000r.es/2af]

F1000Research, 2013
We have established an in vivo visualization system for the geranylgeranylation of proteins in a stably transformed tobacco BY-2 cell line, based on the expression of a dexamethasone-inducible GFP fused to the carboxy-terminal basic domain of the rice ...
Michael Hartmann, Andrea Hemmerlin, Elisabet Gas-Pascual, Esther Gerber, Denis Tritsch, Michel Rohmer, Thomas J Bach   +6 more
doaj   +1 more source

The effect of MEP pathway and other inhibitors on the intracellular localization of a plasma membrane-targeted, isoprenylable GFP reporter protein in tobacco BY-2 cells [v1; ref status: indexed, http://f1000r.es/yx]

F1000Research, 2013
We have established an in vivo visualization system for the geranylgeranylation of proteins in a stably transformed tobacco BY-2 cell line, based on the expression of a dexamethasone-inducible GFP fused to the carboxy-terminal basic domain of the rice ...
Michael Hartmann, Andrea Hemmerlin, Elisabet Gas-Pascual, Esther Gerber, Denis Tritsch, Michel Rohmer, Thomas J Bach   +6 more
doaj   +1 more source

Geranylgeranyl Transferase-I Knockout Inhibits Oxidative Injury of Vascular Smooth Muscle Cells and Attenuates Diabetes-Accelerated Atherosclerosis

Journal of Diabetes Research, 2020
The proliferation of vascular smooth muscle cells (VSMCs) induced by oxidative injury is one of the main features in diabetes-accelerated atherosclerosis.
Guo-Ping Chen, Jian Yang, Guo-Feng Qian, Wei-Wei Xu, Xiao-Qin Zhang   +4 more
doaj   +1 more source