Results 61 to 70 of about 5,118 (209)

Alteration of RhoA Prenylation Ameliorates Cardiac and Vascular Remodeling in Spontaneously Hypertensive Rats

Cellular Physiology and Biochemistry, 2016
Background: In our previous study, farnesyl pyrophosphate synthase (FPPS) was shown to be increased in spontaneously hypertensive rats (SHR) and in mice with angiotensin-II induced cardiac hypertrophy.
Jian Yang, Yu-Ning Chen, Zao-Xian Xu, Yun Mou, Liang-Rong Zheng   +4 more
doaj   +1 more source

Modulation of triglyceride and cholesterol ester synthesis impairs assembly of infectious hepatitis C virus [PDF]

, 2014
In hepatitis C virus infection, replication of the viral genome and virion assembly are linked to cellular metabolic processes. In particular, lipid droplets, which store principally triacylglycerides (TAGs) and cholesterol esters (CEs), have been ...
Hague, Charlotte V., Liefhebber, Jolanda M.P., McLauchlan, John, Wakelam, Michael J.O., Zhang, Qifeng   +4 more
core   +1 more source

Cdc25‐Mediated Activation of the Small GTPase RasB Is Essential for Hyphal Fusion and Symbiotic Infection of Epichloë festucae

Molecular Plant Pathology, Volume 27, Issue 1, January 2026.
A conserved Cdc25–RasB signalling pathway, essential for hyphal fusion and host infection, is repurposed in Epichloë festucae to maintain a stable mutualistic symbiosis with grass hosts. ABSTRACT Epichloë festucae is a filamentous endophytic fungus that symbiotically colonises the intercellular spaces of aerial tissues in perennial ryegrass without ...
Mariko Inagaki, Shota Kamiya, Ayane Okamura, Atsushi Miura, Yuka Kayano, Aiko Tanaka, Daigo Takemoto   +6 more
wiley   +1 more source

Changes in serum and synovial fluid biomarkers after acute injury (NCT00332254) [PDF]

, 2010
INTRODUCTION: Acute trauma involving the anterior cruciate ligament is believed to be a major risk factor for the development of post-traumatic osteoarthritis 10 to 20 years post-injury.
Carl R Flannery, Jonathan B Catterall, Thomas V Stabler, Virginia B Kraus   +3 more
core   +2 more sources

Causal Association Between Plasma Proteins and Pericarditis: A Mendelian Randomization Study With Therapeutic Target Identification

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Background Observational studies demonstrate that pro‐inflammatory cytokines play a critical role in pericarditis. However, the causal association between circulating plasma proteins and pericarditis remains unestablished. Objective This research aimed to assess the causal association between plasma proteins and pericarditis and to investigate ...
Zhexuan Chen, Zongqiang Chen, Lingfeng Peng, Huankai Zhang, Ali Dawood   +4 more
wiley   +1 more source

Zoledronic acid and atorvastatin inhibit αvβ3-mediated adhesion of breast cancer cells

Journal of Bone Oncology, 2014
Bone metastases represent common long term complications of patients with breast cancer. Zoledronic acid, an amino-bisphosphonate and mevalonate pathway inhibitor, is an established agent for the treatment of bone metastases.
Maria Wilke, Andy Göbel, Martina Rauner, Peggy Benad-Mehner, Norbert Schütze, Susanne Füssel, Peyman Hadji, Lorenz C. Hofbauer, Tilman D. Rachner   +8 more
doaj   +1 more source

Anti-tumor effects of mevalonate pathway inhibition in ovarian cancer

BMC Cancer, 2020
Background Ovarian cancer remains the most fatal gynecological malignancy. Current therapeutic options are limited due to late diagnosis in the majority of the cases, metastatic spread to the peritoneal cavity and the onset of chemo-resistance.
Andy Göbel, Valentina M. Zinna, Stefania Dell’Endice, Nikolai Jaschke, Jan Dominik Kuhlmann, Pauline Wimberger, Tilman D. Rachner   +6 more
doaj   +1 more source

The prognostic role and metabolic function of GGPS1 in oral squamous cell carcinoma

Frontiers in Molecular Biosciences, 2023
Background: GGPS1(geranylgeranyl diphosphate synthase 1) is a member of the prenyltransferase family. Abnormal expression of GGPS1 can disrupt the balance between protein farnesylation and geranylgeranylation, thereby affecting a variety of cellular ...
Ke Huang, Ke Huang, Liang Han, Huimei Xu, Ruiming Xu, Hao Guo, Huihui Wang, Zhaoqing Xu   +7 more
doaj   +1 more source

synergistic cytoreductive effects of zoledronic acid and radiation on breast cancer cells [PDF]

, 2006
Introduction Bisphosphonates are mostly used in the treatment of bone metastases. They have been shown to act synergistically with other chemotherapeutic agents. It is not known, however, whether similar synergistic effects exist with radiation on breast
A Ugur Ural, Ferit Avcu, Muhammed Candir, Metin Guden, M Ali Ozcan, A Lipton, AU Ural, M Sato, AU Ural, FP Coxon, F Avcu, S Magnetto, G Van Der Pluijm, LS Rosen, LS Rosen, PJ Hoskin, U Vogt, RJ Tallarida, SG Senaratne, JK Woodward, SP Jagdev, ME Stearns, HL Neville-Webbe, E Algur, S Matsumoto, L Milas, J Sun, X Li, M Salomo, WG McKenna, EJ Bernhard   +30 more
core   +1 more source

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source