Results 61 to 70 of about 3,218 (202)

Conserved statin-mediated activation of the p38-MAPK pathway protects Caenorhabditis elegans from the cholesterol-independent effects of statins

Molecular Metabolism, 2020
Objective: Statins are a group of medications that reduce cholesterol synthesis by inhibiting the activity of HMG-CoA reductase, a key enzyme in the mevalonate pathway. The clinical use of statins to lower excess cholesterol levels has revolutionized the
Irina Langier Goncalves, Sharon Tal, Liza Barki-Harrington, Amir Sapir   +3 more
doaj   +1 more source

Regulating Tumor Metabolic Reprogramming with Biomimetic Co‐Delivery of Simvastatin and Kynureninase for Immunotherapy

Advanced Science, Volume 13, Issue 12, 27 February 2026.
After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin, Shengcai Yang, Zengguang Liu, Songchen Zhao, Siyu Sun, Ziling Liu, Quanshun Li   +6 more
wiley   +1 more source

Modification of Rab5 with a Photoactivatable Analog of Geranylgeranyl Diphosphate [PDF]

Journal of Biological Chemistry, 2001
A photoprobe analog of geranylgeranyl diphosphate (2-diazo-3,3,3-trifluoropropionyloxy-farnesyl diphosphate or DATFP-FPP) inhibits mevalonate-dependent prenylation of in vitro translated Rab5 in rabbit reticulocyte lysate, suggesting that it competes for lipid binding to the Rab geranylgeranyl transferase.
G J, Quellhorst, C M, Allen, M, Wessling-Resnick   +2 more
openaire   +2 more sources

Convergent Metabolic Pathways in MASH Therapeutics: An AMPK‐Centric Analysis

Journal of Cellular and Molecular Medicine, Volume 30, Issue 2, January 2026.
ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) is a leading cause of liver‐related morbidity driven by systemic metabolic dysregulation. The recent approval of resmetirom and the clinical success of GLP‐1 receptor agonists have heralded a new era in MASH therapy, yet a convergent understanding of the complex mechanisms of these ...
Seungchan Choi, Jin‐Seok Jung, Yie‐sung Seo, Sungmin Song, Jeehye Ham, Hannah Chung, Yousef Ramadan, Kangchan Choi   +7 more
wiley   +1 more source

Geranylgeranyl isoprenoids and hepatic Rap1a regulate basal and statin-induced expression of PCSK9

Journal of Lipid Research
LDL-C lowering is the main goal of atherosclerotic cardiovascular disease prevention, and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition is now a validated therapeutic strategy that lowers serum LDL-C and reduces coronary events ...
Yating Wang, Brea Tinsley, Stefano Spolitu, John A. Zadroga, Heena Agarwal, Amesh K. Sarecha, Lale Ozcan   +6 more
doaj   +1 more source

Alteration of RhoA Prenylation Ameliorates Cardiac and Vascular Remodeling in Spontaneously Hypertensive Rats

Cellular Physiology and Biochemistry, 2016
Background: In our previous study, farnesyl pyrophosphate synthase (FPPS) was shown to be increased in spontaneously hypertensive rats (SHR) and in mice with angiotensin-II induced cardiac hypertrophy.
Jian Yang, Yu-Ning Chen, Zao-Xian Xu, Yun Mou, Liang-Rong Zheng   +4 more
doaj   +1 more source

Rab geranylgeranyl transferase catalyzes the geranylgeranylation of adjacent cysteines in the small GTPases Rab1A, Rab3A, and Rab5A. [PDF]

Proceedings of the National Academy of Sciences, 1994
Rab proteins are Ras-related small GTPases that are geranylgeranylated on cysteine residues located at or near their C termini. They differ from other geranylgeranylated small GTPases in several important respects. (i) Most Rab proteins contain two adjacent cysteine residues within one of the following C-terminal sequence motifs: -XXCC, -XCXC, or -CCXX;
C C, Farnsworth, M C, Seabra, L H, Ericsson, M H, Gelb, J A, Glomset   +4 more
openaire   +2 more sources

Cdc25‐Mediated Activation of the Small GTPase RasB Is Essential for Hyphal Fusion and Symbiotic Infection of Epichloë festucae

Molecular Plant Pathology, Volume 27, Issue 1, January 2026.
A conserved Cdc25–RasB signalling pathway, essential for hyphal fusion and host infection, is repurposed in Epichloë festucae to maintain a stable mutualistic symbiosis with grass hosts. ABSTRACT Epichloë festucae is a filamentous endophytic fungus that symbiotically colonises the intercellular spaces of aerial tissues in perennial ryegrass without ...
Mariko Inagaki, Shota Kamiya, Ayane Okamura, Atsushi Miura, Yuka Kayano, Aiko Tanaka, Daigo Takemoto   +6 more
wiley   +1 more source

A novel approach to tag and identify geranylgeranylated proteins [PDF]

ELECTROPHORESIS, 2009
AbstractA recently developed proteomic strategy, the “GG‐azide”‐labeling approach, is described for the detection and proteomic analysis of geranylgeranylated proteins. This approach involves metabolic incorporation of a synthetic azido‐geranylgeranyl analog and chemoselective derivatization of azido‐geranylgeranyl‐modified proteins by the “click ...
Lai N, Chan, Courtenay, Hart, Lea, Guo, Tamara, Nyberg, Brandon S J, Davies, Loren G, Fong, Stephen G, Young, Brian J, Agnew, Fuyuhiko, Tamanoi   +8 more
openaire   +2 more sources

Causal Association Between Plasma Proteins and Pericarditis: A Mendelian Randomization Study With Therapeutic Target Identification

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Background Observational studies demonstrate that pro‐inflammatory cytokines play a critical role in pericarditis. However, the causal association between circulating plasma proteins and pericarditis remains unestablished. Objective This research aimed to assess the causal association between plasma proteins and pericarditis and to investigate ...
Zhexuan Chen, Zongqiang Chen, Lingfeng Peng, Huankai Zhang, Ali Dawood   +4 more
wiley   +1 more source