Results 71 to 80 of about 3,218 (202)

Zoledronic acid and atorvastatin inhibit αvβ3-mediated adhesion of breast cancer cells

Journal of Bone Oncology, 2014
Bone metastases represent common long term complications of patients with breast cancer. Zoledronic acid, an amino-bisphosphonate and mevalonate pathway inhibitor, is an established agent for the treatment of bone metastases.
Maria Wilke, Andy Göbel, Martina Rauner, Peggy Benad-Mehner, Norbert Schütze, Susanne Füssel, Peyman Hadji, Lorenz C. Hofbauer, Tilman D. Rachner   +8 more
doaj   +1 more source

Anti-tumor effects of mevalonate pathway inhibition in ovarian cancer

BMC Cancer, 2020
Background Ovarian cancer remains the most fatal gynecological malignancy. Current therapeutic options are limited due to late diagnosis in the majority of the cases, metastatic spread to the peritoneal cavity and the onset of chemo-resistance.
Andy Göbel, Valentina M. Zinna, Stefania Dell’Endice, Nikolai Jaschke, Jan Dominik Kuhlmann, Pauline Wimberger, Tilman D. Rachner   +6 more
doaj   +1 more source

The prognostic role and metabolic function of GGPS1 in oral squamous cell carcinoma

Frontiers in Molecular Biosciences, 2023
Background: GGPS1(geranylgeranyl diphosphate synthase 1) is a member of the prenyltransferase family. Abnormal expression of GGPS1 can disrupt the balance between protein farnesylation and geranylgeranylation, thereby affecting a variety of cellular ...
Ke Huang, Ke Huang, Liang Han, Huimei Xu, Ruiming Xu, Hao Guo, Huihui Wang, Zhaoqing Xu   +7 more
doaj   +1 more source

A new motif for inhibitors of geranylgeranyl diphosphate synthase [PDF]

Bioorganic & Medicinal Chemistry, 2016
The enzyme geranylgeranyl diphosphate synthase (GGDPS) is believed to receive the substrate farnesyl diphosphate through one lipophilic channel and release the product geranylgeranyl diphosphate through another. Bisphosphonates with two isoprenoid chains positioned on the α-carbon have proven to be effective inhibitors of this enzyme.
Benjamin J, Foust, Cheryl, Allen, Sarah A, Holstein, David F, Wiemer   +3 more
openaire   +2 more sources

The Concise Guide to PHARMACOLOGY 2025/26: Enzymes

British Journal of Pharmacology, Volume 182, Issue S1, Page S307-S403, December 2025.
The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander, Doriano Fabbro, Alasdair J. Gibb, Eamonn Kelly, Alistair A. Mathie, Chloe J. Peach, Emma L. Veale, Jane F. Armstrong, Elena Faccenda, Simon D. Harding, Christopher Southan, Jamie A. Davies, Stephanie Annett, Detlev Boison, Kathryn Elisa Burns, Carmen Dessauer, Jürg Gertsch, Nuala Ann Helsby, Angelo A. Izzo, Rennolds Ostrom, Ester Pagano, Andreas Papapetropoulos, Nigel J. Pyne, Susan Pyne, Tracy Robson, Roland Seifert, Johannes‐Peter Stasch, Csaba Szabo, Mario van der Stelt, Albert van der Vliet, Val Watts, Szu Shen Wong   +31 more
wiley   +1 more source

Treatment with high-dose simvastatin inhibits geranylgeranylation in AML blast cells in a subset of AML patients.

, 2012
Item does not contain fulltextIt is currently unknown whether the in vitro effects observed with statins in acute myeloid leukemia (AML) cells, including lowering of cholesterol, inhibition of isoprenylation, and sensitization to chemotherapy, also occur
de Vries, Elisabeth G. E.; id_orcid, Jonge-Peeters, S. de, Jan Jacob Schuringa, van der Weide, Karen, Elisabeth G.E. de Vries, Huls, Gerwin, Karen van der Weide, Schuringa, J.J., Weide, K. van der, de Jonge-Peeters, Susan, Kuipers, F., Rudolf S.N. Fehrmann, Vries, E.G. de, Fehrmann, Rudolf S. N., Edo Vellenga, Schuringa, Jan Jacob, Folkert Kuipers, Susan de Jonge-Peeters, Huls, G.A., de Vries, Elisabeth G. E., Fehrmann, R.S., Kuipers, Folkert, Kuipers, Folkert; id_orcid, Gerwin Huls, Vellenga, E., Vellenga, Edo   +25 more
core   +1 more source

Identification and characterization of mechanism of action of P61-E7, a novel phosphine catalysis-based inhibitor of geranylgeranyltransferase-I.

PLoS ONE, 2011
Small molecule inhibitors of protein geranylgeranyltransferase-I (GGTase-I) provide a promising type of anticancer drugs. Here, we first report the identification of a novel tetrahydropyridine scaffold compound, P61-E7, and define effects of this ...
Lai N Chan, Hannah D G Fiji, Masaru Watanabe, Ohyun Kwon, Fuyuhiko Tamanoi   +4 more
doaj   +1 more source

A somatic multiple myeloma mutation unravels a mechanism of oligomerization‐mediated product inhibition in GGPPS

The FEBS Journal, Volume 292, Issue 21, Page 5802-5817, November 2025.
Geranylgeranyl diphosphate synthase (GGPPS) plays a key role in multiple myeloma biology. Using crystallography, mass spectrometry, and fluorescence spectroscopy, this study shows that a somatic multiple myeloma cell line mutation destabilizes inter‐dimer interactions, resulting in increased GGPPS activity by facilitating product releas.
Ruba Yehia, Jasmína Mária Portašiková, Rut Mor Yosef, Benny Da'adoosh, Alan Kádek, Petr Man, Moshe Giladi, Yoni Haitin   +7 more
wiley   +1 more source

Atorvastatin reduces long pentraxin 3 expression in vascular cells by inhibiting protein geranylgeranylation

, 2015
Background: The long pentraxin PTX3 is an acute-phase multi-functional protein that might play both positive and detrimental effects under different pathophysiological conditions.
R. Baetta, S. Ghilardi, E. Barbati, S. Lento, C. Banfi, A. Corsini, E. Tremoli   +6 more
core   +1 more source

Statins inhibit blastocyst formation by preventing geranylgeranylation [PDF]

Molecular Human Reproduction, 2016
Statins, inhibitors of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase of the mevalonate pathway and prescription drugs that treat hypercholesterolemia, compromise preimplantation mouse development via modulation of HIPPO signaling.HMG-CoA reductase activity is required for trophectoderm specification, namely blastocyst cavity formation and ...
Vernadeth B, Alarcon, Yusuke, Marikawa
openaire   +2 more sources