Results 81 to 90 of about 5,118 (209)

Differential effects of lovastatin on cisplatin responses in normal human mesothelial cells versus cancer cells: implication for therapy. [PDF]

PLoS ONE, 2012
The cancer killing efficacy of standard chemotherapeutic agents such as cisplatin (CDDP) is limited by their side effects to normal tissues. Therefore, research efforts optimizing the safety and efficacy of those agents are clinically relevant.
Yandong Shi, Emanuela Felley-Bosco, Thomas M Marti, Rolf A Stahel   +3 more
doaj   +1 more source

Human γδ T Cell Function Is Impaired Upon Mevalonate Pathway Inhibition

Immunology, Volume 175, Issue 3, Page 300-322, July 2025.
Mevalonate pathway is important for the effector function of gammadelta T cells. Inhibition of the pathway in vivo and in vitro impairs cytokine and cytotoxic molecule production by mainly affecting protein prenylation and disturbing intracellular signalling in Vdelta2 T cells. Created with Biorender.
Tsz Kin Suen, Burcu Al, Thomas Ulas, Nico Reusch, Harsh Bahrar, Siroon Bekkering, Jaydeep Bhat, Dieter Kabelitz, Joachim L. Schultze, Frank L. van de Veerdonk, Jeanine Roeters van Lennep, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea, Katarzyna Placek   +14 more
wiley   +1 more source

Zoledronic acid inhibits TSC2-null cell tumor growth via RhoA/YAP signaling pathway in mouse models of lymphangioleiomyomatosis

Cancer Cell International, 2020
Background This study is to investigate the effects of zoledronic acid (ZA) on TSC2-null cell proliferation and on the tumor progression and recurrence in mouse models of lymphangioleiomyomatosis (LAM).
Dandan Zhao, Jing Wu, Yinjuan Zhao, Wei Shao, Qi Cheng, Xiaoyan Shao, Xianwen Yuan, Juan Ye, Jianpu Gao, Meiling Jin, Chaojun Li, Xiaolin Chen, Yue Zhao, Bin Xue   +13 more
doaj   +1 more source

RABGGTB plays a critical role in ALS pathogenesis

Brain Research Bulletin
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease with unknown causes, which mainly affects motor neurons in the anterior horn of the spinal cord, brain stem, and cerebral cortex, also known as motor neuron disease.
Haiyang Ma, Jia Huo, Cheng Xin, Jing Yang, Qi Liu, Hui Dong, Rui Li, Yaling Liu   +7 more
doaj   +1 more source

Quantitative Proteomic Analysis Indicates That Pggt1b Deficiency Promotes Cytokine Secretion in Resiquimod‐Stimulated Bone Marrow‐Derived Macrophages via the NF‐κB Pathway

Immunity, Inflammation and Disease, Volume 13, Issue 4, April 2025.
In Pggt1b‐deficient macrophages, TLR4 may be in a highly activated state and can be activated by R848 or DAMPS, which strongly correlated with increased cytokine production, interferon‐γ production, augmented amide binding and transferase activity, and the activation of NF‐κB and/or Nlrp3 inflammasome pathways.
Shanshan Yu, Xuecui Wei, Fangyuan Long, Heng Gu, Zhimin Hao   +4 more
wiley   +1 more source

Mevalonate Pathway Regulates Cell Size Homeostasis and Proteostasis through Autophagy

Cell Reports, 2015
Balance between cell growth and proliferation determines cell size homeostasis, but little is known about how metabolic pathways are involved in the maintenance of this balance.
Teemu P. Miettinen, Mikael Björklund
doaj   +1 more source

Examining Farnesyltransferase Interaction With Cell‐Permeable CaaX Peptides and the Role of the CaaX Motif in Biological Activity

Journal of Peptide Science, Volume 31, Issue 4, April 2025.
This work examines the interaction between farnesyltransferase (FTase) and cell‐permeable CaaX peptides. Particularly, peptide CaaX‐1 is presented as efficient binder to FTase capable to inhibit further interaction of other CaaX motif–bearing peptides. Moreover, biological effects require an intact CaaX motif.
Merlin Klußmann, Jan Reuter, Christian Werner, Ines Neundorf   +3 more
wiley   +1 more source

Supersulfides: A Promising Therapeutic Approach for Autoinflammatory Diseases

Microbiology and Immunology, Volume 69, Issue 4, Page 191-202, April 2025.
ABSTRACT Supersulfides are molecular species characterized by catenated sulfur moieties, including low‐molecular‐weight and protein‐bound supersulfides. Emerging evidence suggests that these molecules, abundantly present in diverse organisms, play essential roles far beyond their chemical properties, such as functions in energy metabolism, protein ...
Tianli Zhang, Touya Toyomoto, Tomohiro Sawa, Takaaki Akaike, Tetsuro Matsunaga   +4 more
wiley   +1 more source

Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11.

PLoS Biology, 2014
Vesicular trafficking plays a key role in tuning the activity of Notch signaling. Here, we describe a novel and conserved Rab geranylgeranyltransferase (RabGGT)-α-like subunit that is required for Notch signaling-mediated lateral inhibition and cell fate
Wu-Lin Charng, Shinya Yamamoto, Manish Jaiswal, Vafa Bayat, Bo Xiong, Ke Zhang, Hector Sandoval, Gabriela David, Stephen Gibbs, Hsiang-Chih Lu, Kuchuan Chen, Nikos Giagtzoglou, Hugo J Bellen   +12 more
doaj   +1 more source

Alendronate induces anti-migratory effects and inhibition of neutral phosphatases in UMR106 osteosarcoma cells [PDF]

, 2007
Bisphosphonates are nonhydrolysable pyrophosphate analogues that prevent bone loss in several types of cancer. However, the mechanisms of anticancer action of bisphosphonates are not completely known.
Bruzzone, L., Cortizo, Ana María, Molinuevo, M.S.   +2 more
core   +2 more sources