Results 81 to 90 of about 3,218 (202)

Simvastatin‐Mediated Molecular Mechanisms Underlying the Growth Inhibition of Testicular Leydig Tumour Cells

Journal of Cellular and Molecular Medicine, Volume 29, Issue 16, August 2025.
ABSTRACT Leydig cell tumours (LCTs) are uncommon stromal neoplasms of the testis, accounting for less than 3% of all gonadal cancers. Most of them are benign, but the malignant ones are very aggressive without specific effective treatment. Several studies reported pharmacologic insight into the use of statins as anti‐tumour agents, but their efficacy ...
Arianna De Luca, Lucia Zavaglia, Lucia Francesca Vuono, Francesca Giordano, Davide La Padula, Francesca De Amicis, Vincenzo Pezzi, Adele Chimento   +7 more
wiley   +1 more source

Dysregulated Cholesterol Metabolism and Its Impact on the Tumour Immune Response in Colorectal Cancer

Journal of Cellular and Molecular Medicine, Volume 29, Issue 15, August 2025.
ABSTRACT Colorectal cancer (CRC) ranks among the primary causes of cancer deaths worldwide. Cholesterol metabolism, tightly regulated through biosynthesis, uptake, efflux and conversion, plays a crucial role in CRC development and progression. Dysregulated cholesterol metabolism in cancer cells alters the tumour microenvironment (TME), promoting tumour
Chunyu Zhang, Zhiwei Miao, Yan Xu, Xingchao Zhu, Tongguo Shi   +4 more
wiley   +1 more source

Dual Mechanisms of ABCA1 Regulation by Geranylgeranyl Pyrophosphate [PDF]

Journal of Biological Chemistry, 2001
ATP-binding cassette transporter A1 (ABCA1) mediates an active efflux of cholesterol and phospholipids and is mutated in patients with Tangier disease. Expression of ABCA1 may be increased by certain oxysterols such as 22(R)-hydroxycholesterol via activation of the nuclear hormone receptor liver X receptor (LXR).
X, Gan, R, Kaplan, J G, Menke, K, MacNaul, Y, Chen, C P, Sparrow, G, Zhou, S D, Wright, T Q, Cai   +8 more
openaire   +2 more sources

Two avian Plasmodium species trigger different transcriptional responses on their vector Culex pipiens

Molecular Ecology, Volume 34, Issue 15, August 2025.
Abstract Malaria is a mosquito‐borne disease caused by protozoans of the genus Plasmodium that affects both humans and wildlife. The fitness consequences of infections by avian malaria are well known in birds, however, little information exists on its impact on mosquitoes.
Marta Garrigós, Guillem Ylla, Josué Martínez‐de la Puente, Jordi Figuerola, María José Ruiz‐López   +4 more
wiley   +1 more source

Protein Farnesyltransferase Catalyzes Unanticipated Farnesylation and Geranylgeranylation of Shortened Target Sequences

, 2020
Protein prenylation is a posttranslational modification involving the attachment of a C15 or C20 isoprenoid group to a cysteine residue near the C-terminus of the target substrate by protein farnesyltransferase (FTase) or protein ...
Colby S. Ruiz (8554755), Emily R. Hildebrandt (8554752), Walter K. Schmidt (1907722), David W. Coreno (8554761), James L. Hougland (202000), Daniel S. Hardgrove (8554758), Sudhat Ashok (8554749)   +6 more
core   +1 more source

Obesity Affects IVF Outcomes and Mevalonic Acid Rescues the Side Effects of Statins on Follicle Growth

The FASEB Journal, Volume 39, Issue 13, 15 July 2025.
Obesity reduces in vitro fertilization pregnancy success, with significant decreases in the number of retrieved oocytes, mature oocytes, and cleavage embryos. Mevalonic acid rescues potential productive toxicity of the lipid‐lowering drug simvastatin in follicular development.
Fei Mao, Jihong Yang, Zhihan Guo, Tianqing Chang, Hua Wu, Guangping Yang, Heqi Dai, Ruizhi Feng, Yun Qian   +8 more
wiley   +1 more source

Human γδ T Cell Function Is Impaired Upon Mevalonate Pathway Inhibition

Immunology, Volume 175, Issue 3, Page 300-322, July 2025.
Mevalonate pathway is important for the effector function of gammadelta T cells. Inhibition of the pathway in vivo and in vitro impairs cytokine and cytotoxic molecule production by mainly affecting protein prenylation and disturbing intracellular signalling in Vdelta2 T cells. Created with Biorender.
Tsz Kin Suen, Burcu Al, Thomas Ulas, Nico Reusch, Harsh Bahrar, Siroon Bekkering, Jaydeep Bhat, Dieter Kabelitz, Joachim L. Schultze, Frank L. van de Veerdonk, Jeanine Roeters van Lennep, Niels P. Riksen, Leo A. B. Joosten, Mihai G. Netea, Katarzyna Placek   +14 more
wiley   +1 more source

Podocyte Geranylgeranyl Transferase Type-I Is Essential for Maintenance of the Glomerular Filtration Barrier

, 2023
Significance StatementA tightly regulated actin cytoskeleton attained through balanced activity of RhoGTPases is crucial to maintaining podocyte function.
Lovisa Bergwall, Bergö, Martin,, Nyström, Jenny,, Bergwall, Lovisa,, Bergwall, L, Jenny Nyström, Buvall, L, Buvall, Lisa,, Boi, R, Roberto Boi, Martin O. Bergö, Lisa Buvall, Ebefors, Kerstin,, Ebefors, K, Boi, Roberto,, Kerstin Ebefors, Bergo, MO, Nystrom, J   +17 more
core   +1 more source

Quantitative Proteomic Analysis Indicates That Pggt1b Deficiency Promotes Cytokine Secretion in Resiquimod‐Stimulated Bone Marrow‐Derived Macrophages via the NF‐κB Pathway

Immunity, Inflammation and Disease, Volume 13, Issue 4, April 2025.
In Pggt1b‐deficient macrophages, TLR4 may be in a highly activated state and can be activated by R848 or DAMPS, which strongly correlated with increased cytokine production, interferon‐γ production, augmented amide binding and transferase activity, and the activation of NF‐κB and/or Nlrp3 inflammasome pathways.
Shanshan Yu, Xuecui Wei, Fangyuan Long, Heng Gu, Zhimin Hao   +4 more
wiley   +1 more source

Inhibition of geranylgeranylation blocks agonist-induced actin reorganization in human airway smooth muscle cells

, 2001
To determine whether RhoA isoprenylation (geranylgeranylation) is required for agonist-induced actin cytoskeleton reorganization (measured by an increase in the filamentous F- to monomeric G-actin ratio), human airway smooth muscle cells were treated for
Defen Zhu, Charles W. Emala, Reynold A. Panettieri, H. Thomas Lee, Ryan E. Lesh, Carol A. Hirshman   +5 more
core   +1 more source