Results 101 to 110 of about 3,218 (202)

In vitro and in vivo effects of geranylgeranyltransferase I inhibitor P61A6 on non-small cell lung cancer cells [PDF]

, 2013
Background Lung cancer is the leading cause of cancer-related mortality. Therapies against non-small cell lung cancer (NSCLC) are particularly needed, as this type of cancer is relatively insensitive to chemotherapy and radiation therapy.
Tamanoi, Fuyuhiko, Veenu Tripathi, Ohyun Kwon, Douglas R Lowy, Lai N Chan, Fuyuhiko Tamanoi, Lowy, Douglas R, Zimonjic, Drazen B, Kwon, Ohyun, Chan, Lai N, Lu, Jie, Nicholas C Popescu, Tripathi, Veenu, Popescu, Nicholas C, Drazen B Zimonjic, Jie Lu   +15 more
core   +1 more source

Schematic of GGPP-mediated protein geranylgeranylation involving in the regulation of primary-secondary follicle transition via remodeling oocyte-granulosa cell communication.

, 2017
Cholesterol was biosynthesized from farnesyl diphosphate (FPP), a metabolic intermediate of the mevalonate pathway. FPP could be catalyzed into another metabolite, geranylgeranyl diphosphate (GGPP), by geranylgeranyl diphosphate synthase (GGPPS).
Xing-Xu Huang (3628259), Fan Diao (3628253), Wei-Wei Tao (3628247), Yong-Juan Sang (3628265), Rui-Lou Zhu (3628256), Xiu-Xing Wang (3628250), Na Xu (188237), Zhong Chen (32985), Hai-Xiang Sun (3628262), Bing Yao (336395), Chao-Jun Li (1442938), Chen Jiang (200126), Bin Xue (388921)   +12 more
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Lovastatin Induces Apoptosis of Anaplastic Thyroid Cancer Cells Via Inhibition of Protein Geranylgeranylation and De Novo Protein Synthesis

, 2008
Lovastatin has been used to treat hypercholesterolemia through blocking the mevalonate biosynthesis pathway. Inhibition of mevalonate synthesis may result in antiproliferation and cell apoptosis.
鍾文彬;王治元;張天鈞;李文森, ZHONG, WEN-BIN;WANG, CHIH-YUAN;CHANG, TIEN-CHUN;LEE, WEN-SEN   +1 more
core  

Modification analysis of the 36 APXs.

, 2019
A: Number of Phosphorylation sites. B: Number of S-Nitrosylation, S-Palmitoylation, N-Myristoylation, S-Farnesylation and S-Geranylgeranylation sites.
Baomei Wu (8157321), Binbin Wang (161690)   +1 more
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Farnesylation of Retinal Transducin Underlies Its Translocation during Light Adaptation

, 2005
SummaryG proteins are posttranslationally modified by isoprenylation: either farnesylation or geranylgeranylation. The γ subunit of retinal transducin (Tα/Tβγ) is selectively farnesylated, and the farnesylation is required for light signaling mediated by
Xiong, Wei-Hong, Satomi, Yoshinori, Yau, King-Wai, Imai, Hiroo, Takao, Toshifumi, Shichida, Yoshinori, Katsuki, Motoya, Fukada, Yoshitaka, Aiba, Atsu, Nakamura, Kenji, Nakao, Kazuki, Kassai, Hidetoshi, Okano, Toshiyuki   +12 more
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Associação entre miopatia induzida por estatinas e exercício físico [PDF]

, 2011
Dissertação (mestrado profissional) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaIntrodução: Ainda permanece pouco entendido se a associação entre exercício e estatina é condição ...
Brogliatto, Fernanda Seimetz
core  

Pyrin inflammasome-driven erosive arthritis caused by unprenylated RHO GTPase signaling

EMBO Molecular Medicine
Geranylgeranyl pyrophosphate, a non-sterol intermediate of the mevalonate pathway, serves as the substrate for protein geranylgeranylation, a process catalyzed by geranylgeranyl transferase I (GGTase-I).
Murali K Akula, Elisabeth Gilis, Pieter Hertens, Lieselotte Vande Walle, Mozes Sze, Julie Coudenys, Yunus Incik, Omar Khan, Martin O Bergo, Dirk Elewaut, Andy Wullaert, Mohamed Lamkanfi, Geert van Loo   +12 more
doaj   +1 more source

Human Geranylgeranyl Diphosphate Synthase [PDF]

Journal of Biological Chemistry, 1999
Tsuyoshi Kuzuguchi, Yuiko Morita, Ikuko Sagami, Hiroshi Sagami, Kyozo Ogura   +4 more
openaire   +1 more source

Efeitos da sinvastatina em modelo de osteoartrite em ratos [PDF]

, 2009
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pos-Graduação em Farmacologia, Florianópolis, 2009.A osteoartrite é uma doença articular degenerativa, progressiva e irreversível para a qual não ...
Castro, Gláucio Ricardo Werner de
core  

Corrigendum: A Requirement of Protein Geranylgeranylation for Chemokine Receptor Signaling and Th17 Cell Function in an Animal Model of Multiple Sclerosis

Frontiers in Immunology, 2021
Gregory Swan, Gregory Swan, Jia Geng, Eunchong Park, Quanquan Ding, John Zhou, Ciana Walcott, Junyi J. Zhang, Hsin-I. Huang, Gianna Hammer, Donghai Wang, Donghai Wang   +11 more
doaj   +1 more source