Results 101 to 110 of about 5,118 (209)

The 4G/5G PAI-1 polymorphism influences the endothelial response to IL-1 and the modulatory effect of pravastatin [PDF]

, 2006
BACKGROUND: Increased plasminogen activator inhibitor (PAI-1) levels lead to impaired fibrinolytic function associated with higher cardiovascular risk. PAI-1 expression may be regulated by different inflammatory cytokines such as interleukin-1alpha (IL-1)
Belzunce, M. (Miriam), Orbe, J. (Josune), Paramo, J.A. (José Antonio), Rodriguez, J.A. (José Antonio), Roncal, C. (Carmen)   +4 more
core  

Microtubule motors transport phagosomes in the RPE, and lack of KLC1 leads to AMD-like pathogenesis. [PDF]

, 2015
The degradation of phagosomes, derived from the ingestion of photoreceptor outer segment (POS) disk membranes, is a major role of the retinal pigment epithelium (RPE). Here, POS phagosomes were observed to associate with myosin-7a, and then kinesin-1, as
Diemer, Tanja, Esteve-Rudd, Julian, Jiang, Mei, Lillo, Concepción, Lopes, Vanda S, Rump, Agrani, Williams, David S   +6 more
core   +1 more source

Solid State Fermentation: An Effective Method for Lovastatin Production by Fungi over Submerged Fermentation [PDF]

, 2012
The Enzyme 3-hydroxy-3-methylglutaryl-CoA reductase (HMG CoA reductase) catalyses conversion of HMG CoA to mevalonate during cholesterol biosynthesis. Lovastatin is used as an anti-cholesterol drug which blocks HMG CoA reductase activity.
Praveen, V.K., Savitha, J.
core  

Human Geranylgeranyl Diphosphate Synthase [PDF]

Journal of Biological Chemistry, 1999
Tsuyoshi Kuzuguchi, Yuiko Morita, Ikuko Sagami, Hiroshi Sagami, Kyozo Ogura   +4 more
openaire   +1 more source

Tumor suppressive Ca2+ signaling is driven by IP3 receptor fitness [PDF]

, 2017
Bultynck, G, Campanella, M
core   +3 more sources

Regulation of dolichol-linked glycosylation [PDF]

, 2018
In the majority of congenital disorders of glycosylation, the assembly of the glycan precursor GlcNAc2Man9Glc3 on the polyprenol carrier dolichyl-pyrophosphate is compromised.
Welti, Michael
core  

Pyrin inflammasome-driven erosive arthritis caused by unprenylated RHO GTPase signaling

EMBO Molecular Medicine
Geranylgeranyl pyrophosphate, a non-sterol intermediate of the mevalonate pathway, serves as the substrate for protein geranylgeranylation, a process catalyzed by geranylgeranyl transferase I (GGTase-I).
Murali K Akula, Elisabeth Gilis, Pieter Hertens, Lieselotte Vande Walle, Mozes Sze, Julie Coudenys, Yunus Incik, Omar Khan, Martin O Bergo, Dirk Elewaut, Andy Wullaert, Mohamed Lamkanfi, Geert van Loo   +12 more
doaj   +1 more source

Geranylgeranyl Transferase [PDF]

, 2020
openaire   +1 more source

Corrigendum: A Requirement of Protein Geranylgeranylation for Chemokine Receptor Signaling and Th17 Cell Function in an Animal Model of Multiple Sclerosis

Frontiers in Immunology, 2021
Gregory Swan, Gregory Swan, Jia Geng, Eunchong Park, Quanquan Ding, John Zhou, Ciana Walcott, Junyi J. Zhang, Hsin-I. Huang, Gianna Hammer, Donghai Wang, Donghai Wang   +11 more
doaj   +1 more source

The Rho-kinase inhibitor HA-1077 suppresses proliferation/migration and induces apoptosis of urothelial cancer cells [PDF]

, 2014

core   +1 more source