Results 91 to 100 of about 3,218 (202)

Examining Farnesyltransferase Interaction With Cell‐Permeable CaaX Peptides and the Role of the CaaX Motif in Biological Activity

Journal of Peptide Science, Volume 31, Issue 4, April 2025.
This work examines the interaction between farnesyltransferase (FTase) and cell‐permeable CaaX peptides. Particularly, peptide CaaX‐1 is presented as efficient binder to FTase capable to inhibit further interaction of other CaaX motif–bearing peptides. Moreover, biological effects require an intact CaaX motif.
Merlin Klußmann, Jan Reuter, Christian Werner, Ines Neundorf   +3 more
wiley   +1 more source

Supersulfides: A Promising Therapeutic Approach for Autoinflammatory Diseases

Microbiology and Immunology, Volume 69, Issue 4, Page 191-202, April 2025.
ABSTRACT Supersulfides are molecular species characterized by catenated sulfur moieties, including low‐molecular‐weight and protein‐bound supersulfides. Emerging evidence suggests that these molecules, abundantly present in diverse organisms, play essential roles far beyond their chemical properties, such as functions in energy metabolism, protein ...
Tianli Zhang, Touya Toyomoto, Tomohiro Sawa, Takaaki Akaike, Tetsuro Matsunaga   +4 more
wiley   +1 more source

Inhibition of protein geranylgeranylation specifically interferes with CD40-dependent B cell activation, resulting in a reduced capacity to induce T cell immunity

, 2014
Ab-independent effector functions of B cells, such as Ag presentation and cytokine production, have been shown to play an important role in a variety of immune-mediated conditions such as autoimmune diseases, transplant rejection, and graft-versus-host ...
Shimabukuro-Vornhagen, A., von Bergwelt-Baildon, M.S., Draube, A., Zoghi, S., Pallasch, C., Chemitz, J., Blaschke, F., Holtick, U., Theurich, S., Kochanek, M., Hallek, M., Liebig, T.M., Wennhold, K., Scheid, C.   +13 more
core   +1 more source

Pivaloyloxtmethyl-modified isoprenoid bisphosphonates display enhanced inhibition of cellular geranylgeranylation

, 2008
Nitrogenous bisphosphonate inhibitors of farnesyl disphosphate synthase have been used clinically for treatment of bone disease. Because many of their effects may be mediated by depletion of geranylgeranyl diphosphate, our group has sought compounds ...
Wasko, Brian
core  

The plastidial 2-C-methyl-D-erythritol 4-phosphate pathway provides the isoprenyl moiety for protein geranylgeranylation in tobacco BY-2 cells

, 2009
17 pages, 11 figures.-- PMID: 19136647 [PubMed].-- PMCID: PMC2648074.-- Supplementay information available at: http://www.plantcell.org/cgi/content/full/tpc.108.063248/DC1Protein farnesylation and geranylgeranylation are important posttranslational ...
Hartmann, Michael, Hartmann, Marie-Andrée, Rohmer, Michel, Bach, Thomas J., Heintz, Dimitri, Boronat, Albert, Rodríguez Concepción, Manuel, Mutterer, Jerome, Crowell, Dring N., Gerber, Esther, Van Dorsselaer, Alain, Hemmerlin, Andréa   +11 more
core   +1 more source

Geranylgeranylation but not GTP loading determines rho migratory function in T cells

, 2007
Rho GTPases orchestrate signaling pathways leading to cell migration. Their function depends on GTP loading and isoprenylation by geranylgeranyl pyrophosphate (GGpp).
Bendix, I, Brocke, S, Brandt, A U, Herz, J., Brocke, S., Waiczies, S, Pfueller, C.F., Herz, J, Prozorovski, T., Ratner, M, Nazarenko, I, Waiczies, S., Nazarenko, I., Pfueller, C F, Ratner, M., Prozorovski, T, Zipp, F, Ullrich, O., Brandt, A.U., Bendix, I., Ullrich, O, Zipp, F.   +21 more
core   +1 more source

Lovastatin Suppresses Invasiveness of Anaplastic Thyroid Cancer Cells by Inhibiting Rho Geranylgeranylation and Rhoa/Rock Signaling

, 2008
Lovastatin, a competitive inhibitor of 3-hydroxy-3- methylglutaryl (HMG)- CoA reductase, inhibits the conversion of mevalonate from HMG-CoA. Previously, we have reported that lovastatin treatment induced the occurrence of apoptosis and differentiation in
ZHONG, WEN-BIN;LIANG, YU-CHIH;WANG, CHIH-YUAN;CHANG, TIEN-CHUN;LEE, WEN-SEN, 鍾文彬;梁有志;王治元;張天鈞;李文森   +1 more
core  

Farnesylation or geranylgeranylation? Efficient assays for testing protein prenylation in vitro and in vivo

, 2006
Background: Available in vitro and in vivo methods for verifying protein substrates for posttranslational modifications via farnesylation or geranylgeranylation (for example, autoradiography with 3H-labeled anchor precursors) are time consuming (weeks ...
Benetka, Wolfgang (Universität Wien), Maurer-Stroh, Sebastian (Universität Wien), Koranda, Manfred (University of Vienna), Eisenhaber, Frank (University of Vienna), Pittner, Fritz (University of Vienna)   +4 more
core   +1 more source

Geranylgeranylation but not GTP-loading of Rho GTPases determines T cell function

, 2008
Rho guanosine triphosphatases (GTPases) orchestrate signaling pathways leading to cell migration. They are typically responsible for the organization of actin filaments that support actomyosin contractility and cell-body translocation.
Sonia Waiczies, Frauke Zipp, Bendix, I., Waiczies, S., Zipp, F., Ivo Bendix   +5 more
core   +1 more source

Inhibiting geranylgeranylation blocks growth and promotes apoptosis in pulmonary vascular smooth muscle cells

, 1998
The activity of small GTP-binding proteins is regulated by a critical step in posttranslational processing, namely, the addition of isoprenoid lipids farnesyl and geranylgeranyl, mediated by the enzymes farnesyltransferase (FTase) and ...
Michelle A. Blaskovich, Anil Vasudevan, Saïd M. Sebti, William W. Stark, Yimin Qian, Paul Davies, Bruce A. Johnson, Bruce Pitt, Andrew D. Hamilton   +8 more
core   +1 more source