Results 51 to 60 of about 5,118 (209)
The rab3A-22A chimera prevents sperm exocytosis by stabilizing open fusion pores [PDF]
, 2016 At the final stage of exocytotis, a fusion pore opens between the plasma and a secretory vesicle membranes; typically, when the pore dilates the vesicle releases its cargo.
Bustos, Matias Alberto +5 more
core +1 more source
Medicinal Research Reviews, Volume 46, Issue 2, Page 352-381, March 2026.ABSTRACT A plethora of cellular signaling pathways are dysregulated in cancer cells, promoting carcinogenesis and migration. Cholesterol has recently been linked to cancer by several subcellular mechanisms, especially by its involvement in the formation of lipid rafts, which promote oncogenic signaling and cancer cell invasion. Squalene synthase (SQS),
Danai Mavridi +2 more
wiley +1 more source
Molecular Metabolism, 2020 Objective: Statins are a group of medications that reduce cholesterol synthesis by inhibiting the activity of HMG-CoA reductase, a key enzyme in the mevalonate pathway. The clinical use of statins to lower excess cholesterol levels has revolutionized the
Irina Langier Goncalves +3 more
doaj +1 more source
Simvastatin inhibits TGFβ1-induced fibronectin in human airway fibroblasts [PDF]
, 2011 Background Bronchial fibroblasts contribute to airway remodelling, including airway wall fibrosis. Transforming growth factor (TGF)-β1 plays a major role in this process.
Dedmer Schaafsma +8 more
core +2 more sources
Deficient Geranylgeranylation of Ram/Rab27 in Choroideremia [PDF]
Journal of Biological Chemistry, 1995 Choroideremia, an X-linked form of retinal degeneration, results from defects in the Rab escort protein-1 (REP-1) gene. REP-1 and REP-2 assist in the attachment of geranylgeranyl groups to Rab GTPases, a modification essential for their action as molecular switches regulating intracellular vesicular transport.
M C, Seabra, Y K, Ho, J S, Anant
openaire +2 more sources
Advanced Science, Volume 13, Issue 12, 27 February 2026.After the intravenous injection of biomimetic and pH/ROS‐responsive PTSK@CRM, the nanoparticles can be accumulated in tumors and release Sim and KYNase to inhibit the tumor growth, regulate the metabolism of cholesterol and Kyn, and reverse the immunosuppressive tumor microenvironment.
Jiaxin Yin +6 more
wiley +1 more source
Generation of specific antibodies against the rap1A, rap1B and rap2 small GTP-binding proteins. Analysis of rap and ras proteins in membranes from mammalian cells [PDF]
, 1992 Specific antibodies against rap1A and rap1B small GTP-binding proteins were generated by immunization of rabbits with peptides derived from the C-terminus of the processed proteins.
Frank, R. +5 more
core +1 more source
Plant Methods, 2023 Abstract Background Isoprenoids are a very large class of metabolites playing a key role in plant physiological processes such as growth, stress resistance, fruit flavor, and color. In chloroplasts and chromoplasts, the diterpene compound geranylgeranyl diphosphate (GGPP) is the metabolic ...
Zita, Wayne +5 more
openaire +4 more sources
Convergent Metabolic Pathways in MASH Therapeutics: An AMPK‐Centric Analysis
Journal of Cellular and Molecular Medicine, Volume 30, Issue 2, January 2026.ABSTRACT Metabolic dysfunction‐associated steatohepatitis (MASH) is a leading cause of liver‐related morbidity driven by systemic metabolic dysregulation. The recent approval of resmetirom and the clinical success of GLP‐1 receptor agonists have heralded a new era in MASH therapy, yet a convergent understanding of the complex mechanisms of these ...
Seungchan Choi +7 more
wiley +1 more source
Geranylgeranyl isoprenoids and hepatic Rap1a regulate basal and statin-induced expression of PCSK9
Journal of Lipid ResearchLDL-C lowering is the main goal of atherosclerotic cardiovascular disease prevention, and proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition is now a validated therapeutic strategy that lowers serum LDL-C and reduces coronary events ...
Yating Wang +6 more
doaj +1 more source