Results 31 to 40 of about 3,218 (202)

Geranylgeranyl Switching Regulates [PDF]

Structure, 2003
AbstractRab GTPases, key regulators of membrane targeting and fusion, require the covalent attachment of geranylgeranyl lipids to their C terminus for function. To elucidate the role of lipid in Rab recycling, we have determined the crystal structure of Rab guanine nucleotide dissociation inhibitor (αGDI) in complex with a geranylgeranyl (GG) ligand ...
An, Yu, Shao, Ying, Alory, Christelle, Matteson, Jeanne, Sakisaka, Toshiaki, Chen, Wei, Gibbs, Richard A, Wilson, Ian A, Balch, William E   +8 more
openaire   +1 more source

GGPS1 Promoter Variant (rs3806394) Is Associated With Larger Simple Renal Cysts via Reduced GGPPS Expression. [PDF]

Hum Mutat
Objective We are aimed at investigating the association between the size of simple renal cyst (SRC) and the expression of geranylgeranyl pyrophosphate synthase (GGPPS), which can induce renal cyst formation after its deletion. Methods Seventy‐seven patients who received renal cyst decortication were enrolled.
Wang K, Tang T, Xu T, Chen Z, Gou L, Wang Y, Wang D, Wu J, Wang X, Xue B, Xu X.   +10 more
europepmc   +2 more sources

Compromized geranylgeranylation of RhoA and Rac1 in mevalonate kinase deficiency [PDF]

, 2010
Mevalonate kinase deficiency (MKD) is an autoinflammatory disorder caused by mutations in the MVK gene resulting in decreased activity of the enzyme mevalonate kinase (MK).
Turkenburg, M., Schneiders, M.S., Waterham, H.R., Waterham, H. R., L. Henneman, M. S. Schneiders, Schneiders, M. S., Henneman, L., M. Turkenburg, H. R. Waterham   +9 more
core   +1 more source

Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome

Journal of Lipid Research, 2009
Hutchinson-Gilford progeria syndrome (HGPS) is caused by the synthesis of a truncated prelamin A, commonly called progerin, that contains a carboxyl-terminal farnesyl lipid anchor.
Brandon S.J. Davies, Shao H. Yang, Emily Farber, Roger Lee, Suzanne B. Buck, Douglas A. Andres, H. Peter Spielmann, Brian J. Agnew, Fuyuhiko Tamanoi, Loren G. Fong, Stephen G. Young   +10 more
doaj   +1 more source

Design and Evaluation of Bivalent K-Ras Inhibitors That Target the CAAX Binding Site and the Acidic Surface of Farnesyltransferase and Geranylgeranyltransferase I. [PDF]

Chemistry
Chemical inhibition of K‐Ras posttranslational prenylation represents a promising strategy against aggressive cancers. A structure‐based design produces piperidine‐based peptidomimetics conjugated to cationic modules, effectively inhibiting FTase and GGTase I at single‐digit nanomolar concentrations.
Horiuchi N, Omer R, Sugino F, Ogino N, Inoue Y, Aslamuzzaman K, Suzuki T, Sebti SM, Ohkanda J.   +8 more
europepmc   +2 more sources

Deficient Geranylgeranylation of Ram/Rab27 in Choroideremia [PDF]

Journal of Biological Chemistry, 1995
Choroideremia, an X-linked form of retinal degeneration, results from defects in the Rab escort protein-1 (REP-1) gene. REP-1 and REP-2 assist in the attachment of geranylgeranyl groups to Rab GTPases, a modification essential for their action as molecular switches regulating intracellular vesicular transport.
M C, Seabra, Y K, Ho, J S, Anant
openaire   +2 more sources

Synthesis of the 6-Substituted Imidazo[1,2-a]Pyridine-3-yl-2- Phosphonopropionic Acids as Potential Inhibitors of Rab Geranylgeranyl Transferase

Frontiers in Chemistry, 2021
Twelve phosphonopropionates derived from 2-hydroxy-3-imidazo[1,2-a]pyridin-3-yl-2-phosphonopropionic acid (3-IPEHPC) were synthesized and evaluated for their activity as inhibitors of protein geranylgeranylation.
Damian Kusy, Aleksandra Marchwicka, Joanna Małolepsza, Katarzyna Justyna, Katarzyna Justyna, Edyta Gendaszewska-Darmach, Katarzyna Magdalena Błażewska   +6 more
doaj   +1 more source

Geranylgeranyl pyrophosphate depletion by statins compromises skeletal muscle insulin sensitivity

Journal of Cachexia, Sarcopenia and Muscle, 2022
Background Statins are widely prescribed cholesterol‐lowering drugs but have been shown to increase the risk of type 2 diabetes mellitus. However, the molecular mechanisms underlying the diabetogenic effect of statins are still not fully understood ...
Lai Wang, Zuguo Zheng, Lijun Zhu, Lingchang Meng, Hanling Liu, Keke Wang, Jun Chen, Ping Li, Hua Yang   +8 more
doaj   +1 more source

Thematic review series: Lipid Posttranslational Modifications. Geranylgeranylation of Rab GTPases

Journal of Lipid Research, 2006
Rab GTPases require special machinery for protein prenylation, which include Rab escort protein (REP) and Rab geranylgeranyl transferase (RGGT). The current model of Rab geranylgeranylation proposes that REP binds Rab and presents it to RGGT.
Ka Fai Leung, Rudi Baron, Miguel C. Seabra   +2 more
doaj   +1 more source

Nucleotide Dependence of Rab Geranylgeranylation [PDF]

Journal of Biological Chemistry, 1996
Miguel C. Seabra
openaire   +2 more sources