Results 141 to 150 of about 6,405 (188)

Protein Farnesylation on Nasopharyngeal Carcinoma, Molecular Background and Its Potential as a Therapeutic Target

Cancers, 2022
SIMPLE SUMMARY: Nasopharyngeal carcinoma is distinguished from other head and neck carcinomas by the association of its carcinogenesis with the Epstein–Barr virus.
Naohiro Wakisaka, Eiji Kobayashi, Nobuyuki Hirai   +2 more
exaly   +2 more sources

Protein farnesylation is involved in nitrogen starvation adaptation in Arabidopsis

Environmental and Experimental Botany, 2023
International audienceNitrogen is an important element that controls plant growth and yield. Recently we showed that protein farnesylation is involved in nitrate-driven root architecture organization in Arabidopsis.
Eric Ducos, Cecile Vincent-Barbaroux, Alexandra Launay-Avon   +2 more
exaly   +2 more sources

Protein farnesylation: Implications for normal physiology, malignant transformation, and cancer therapy [PDF]

Cancer Cell, 2005
Protein farnesylation is a lipid posttranslational modification required for the cancer-causing activity of proteins such as the GTPase Ras. Although farnesyltransferase inhibitors (FTIs) are in clinical trials, their mechanism of action and the role of ...
Said Sebti
exaly   +2 more sources

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Farnesyl-Derived Inhibitors of ras Farnesyl Transferase

Biochemical and Biophysical Research Communications, 1995
The synthesis and evaluation of farnesyl-derived inhibitors of ras farnesyl transferase are presented. Evaluation of inhibitors of farnesyl transferase and comparison with the previously described inhibitor was accomplished using purified enzyme and Amersham's Farnesyl:Transferase enzyme assay kit.
M S, Kang, D M, Stemerick, J H, Zwolshen, B S, Harry, P S, Sunkara, B L, Harrison   +5 more
openaire   +2 more sources

Insights into the Function of Prenylation from Nuclear Lamin Farnesylation

The Enzymes, 2011
The discovery of mammalian protein prenylation was originally motivated by an effort to identify a nonsterol isoprenoid which indirect evidence suggested was a coregulator of isoprenoid biosynthesis and played a critical role in cellular proliferation ...
Michael Sinensky
exaly   +2 more sources

Protein farnesylation and disease

Journal of Inherited Metabolic Disease, 2012
AbstractPrenylation consists of the addition of an isoprenoid group to a cysteine residue located near the carboxyl terminal of a protein. This enzymatic posttranslational modification is important for the maturation and processing of proteins. Both processes are necessary to mediate protein‐protein and membrane‐protein associations, in addition to ...
NOVELLI, GIUSEPPE, D'APICE, MARIA ROSARIA   +1 more
openaire   +4 more sources

Farnesyl Transferase Inhibitors

Cancer Investigation, 2007
Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
Tianhong, Li, Joseph A, Sparano
openaire   +2 more sources

Farnesyl Diphosphate-Based Inhibitors of Ras Farnesyl Protein Transferase

Journal of Medicinal Chemistry, 1995
The rational design, synthesis, and biological activity of farnesyl diphosphate (FPP)-based inhibitors of the enzyme Ras farnesyl protein transferase (FPT) is described. Compound 3, wherein a beta-carboxylic phosphonic acid type pyrophosphate (PP) surrogate is connected to the hydrophobic farnesyl group by an amide linker, was found to be a potent (I50(
D V, Patel, R J, Schmidt, S A, Biller, E M, Gordon, S S, Robinson, V, Manne   +5 more
openaire   +2 more sources

Photoaffinity Analogues of Farnesyl Pyrophosphate Transferable by Protein Farnesyl Transferase

Journal of the American Chemical Society, 2002
Farnesylation is a posttranslational lipid modification in which a 15-carbon farnesyl isoprenoid is linked via a thioether bond to specific cysteine residues of proteins in a reaction catalyzed by protein farnesyltransferase (FTase). We synthesized analogues (3-6) of farnesyl pyrophosphate (FPP) to probe the range of modifications possible to the FPP ...
Kareem A H, Chehade, Katarzyna, Kiegiel, Richard J, Isaacs, Jennifer S, Pickett, Katherine E, Bowers, Carol A, Fierke, Douglas A, Andres, H Peter, Spielmann   +7 more
openaire   +2 more sources

Stereochemistry‐dependent inhibition of RAS farnesylation by farnesyl phosphonic acids

Lipids, 1998
AbstractThis investigation compares the effects of three farnesyl pyrophosphate analogs on selected aspects of isoprenoid metabolism. E,E‐α‐Hydroxyfarnesylphosphonate was prepared by an improved variation on a literature synthesis, which also gave access to the new Z,E‐α‐hydroxyfarnesyl‐ and α‐hydroxygeranylphosphonates.
R J, Hohl, K A, Lewis, D M, Cermak, D F, Wiemer   +3 more
openaire   +2 more sources