Results 151 to 160 of about 6,054 (206)

Simvastatin-Mediated Molecular Mechanisms Underlying the Growth Inhibition of Testicular Leydig Tumour Cells. [PDF]

J Cell Mol Med
De Luca A, Zavaglia L, Vuono LF, Giordano F, La Padula D, De Amicis F, Pezzi V, Chimento A.   +7 more
europepmc   +1 more source

Regulation of Adaptive Immunity by Lipid Post-translational Modifications. [PDF]

Immune Netw
Mattingly JR, Wu A, York AG.
europepmc   +1 more source

Protein lipidation in the tumor microenvironment: enzymology, signaling pathways, and therapeutics. [PDF]

Mol Cancer
Xu M, Xu B.
europepmc   +1 more source

Sortase A-mediated farnesylation of Cdc42 in vitro

Tschirpke S, Hettema NM, Spitzbarth B, Eelkema R, Laan L.   +4 more
europepmc   +1 more source

Protein Farnesylation on Nasopharyngeal Carcinoma, Molecular Background and Its Potential as a Therapeutic Target

Cancers, 2022
SIMPLE SUMMARY: Nasopharyngeal carcinoma is distinguished from other head and neck carcinomas by the association of its carcinogenesis with the Epstein–Barr virus.
Eiji Kobayashi, Takeshi Komori, Yosuke Nakanishi   +2 more
exaly   +2 more sources

Protein farnesylation is involved in nitrogen starvation adaptation in Arabidopsis

Environmental and Experimental Botany, 2023
International audienceNitrogen is an important element that controls plant growth and yield. Recently we showed that protein farnesylation is involved in nitrate-driven root architecture organization in Arabidopsis.
Benoit Porcheron, Eric Ducos, Muriel Feinard-Duranceau   +2 more
exaly   +2 more sources

Protein farnesylation: Implications for normal physiology, malignant transformation, and cancer therapy

Cancer Cell, 2005
Protein farnesylation is a lipid posttranslational modification required for the cancer-causing activity of proteins such as the GTPase Ras. Although farnesyltransferase inhibitors (FTIs) are in clinical trials, their mechanism of action and the role of ...
Said M Sebti
exaly   +2 more sources

Insights into the Function of Prenylation from Nuclear Lamin Farnesylation

The Enzymes, 2011
The discovery of mammalian protein prenylation was originally motivated by an effort to identify a nonsterol isoprenoid which indirect evidence suggested was a coregulator of isoprenoid biosynthesis and played a critical role in cellular proliferation ...
Michael Sinensky
exaly   +2 more sources

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Farnesyl-Derived Inhibitors of ras Farnesyl Transferase

Biochemical and Biophysical Research Communications, 1995
The synthesis and evaluation of farnesyl-derived inhibitors of ras farnesyl transferase are presented. Evaluation of inhibitors of farnesyl transferase and comparison with the previously described inhibitor was accomplished using purified enzyme and Amersham's Farnesyl:Transferase enzyme assay kit.
M S, Kang, D M, Stemerick, J H, Zwolshen, B S, Harry, P S, Sunkara, B L, Harrison   +5 more
openaire   +2 more sources

Farnesyl Transferase Inhibitors

Cancer Investigation, 2007
Substituted imidazoles and thiazoles having the formula are useful for inhibiting farnesyltransferase. Also disclosed are farnesyltransferase-inhibiting compositions and methods of inhibiting farnesyltransferase in a patient.
Tianhong, Li, Joseph A, Sparano
openaire   +3 more sources