Results 101 to 110 of about 622,986 (383)

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

A tool for helping operations research [PDF]

, 1994
This paper describes an integrated environment in which a student can acquire and test knowledge about Operations Research techniques. In this environment all the interactions with the users are performed by means of an appropriated graphical interface ...
Costa, AFB, Marins, FAS, Senne, ELF
core  

Effect of fulvic acids on lead-induced oxidative stress to metal sensitive Vicia faba L. plant [PDF]

, 2012
Lead (Pb) is a ubiquitous environmental pollutant capable to induce various morphological, physiological, and biochemical functions in plants. Only few publications focus on the influence of Pb speciation both on its phytoavailability and phytotoxicity ...
Shahid, Muhammad, Dumat, Camille, Silvestre, Jérôme, Pinelli, Eric   +3 more
core   +1 more source

An Opto‐Actuated Hydrogel for Cell Mechanoactuation and Real‐Time Force Monitoring

Advanced Science, EarlyView.
Researchers developed a mechanoactuated hydrogel interface where nanomachines exert forces on adhesion receptors and allow monitoring of traction force responses in real time. They demonstrate reversible talin recruitment, enhanced F‐actin polymerization, and a reduction in cell traction force when force is locally applied to focal adhesions of ...
Rinku Kumar, Marc A. Fernandez‐Yague, Adrien Bessaguet, Hosoowi Lee, Nicolas Giuseppone, Andrés J. García, Aránzazu del Campo   +6 more
wiley   +1 more source

FAS and ACC dysfunction in visceral Adipose Tissue

پیاورد سلامت, 2020
Background and Aim: A great interest for determining the particular mechanisms underlying lipogenesis and adipogenesis has been raised among researchers in order to fight obesity.
Ehsan khalili, Naghmeh Janat Alipour, Reza Meshkani, Karamolah Tolabi, Solaleh Emamgholipour   +4 more
doaj  

Conversion of Membrane-bound Fas(CD95) Ligand to Its Soluble Form Is Associated with Downregulation of Its Proapoptotic Activity and Loss of Liver Toxicity

Journal of Experimental Medicine, 1998
Human Fas ligand (L) (CD95L) and tumor necrosis factor (TNF)-α undergo metalloproteinase-mediated proteolytic processing in their extracellular domains resulting in the release of soluble trimeric ligands (soluble [s]FasL, sTNF-α) which, in the case of ...
P. Schneider, N. Holler, J. Bodmer, M. Hahne, K. Frei, A. Fontana, J. Tschopp   +6 more
semanticscholar   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source

A connection between levels of soluble Fas and Fas ligand in the aqueous humor and the parameters of structural and functional damage of glaucoma patients [PDF]

Srpski Arhiv za Celokupno Lekarstvo
Introduction/Objective Fas ligand (FasL) induces apoptosis when interacting with the Fas-receptor. The aim was to determine the concentration of soluble Fas (sFas) and soluble FasL (sFasL) in the aqueous humor (AH) of open-angle glaucoma patients, and ...
Trenkić Marija, Jevtović-Stoimenov Tatjana, Bašić Jelena, Stamenković Miroslav, Jocić-Đorđević Jasmina, Trenkić Milan   +5 more
doaj   +1 more source

HIV-1 Directly Kills CD4+ T Cells by a Fas-independent Mechanism [PDF]

, 1998
The mechanism by which HIV-1 induces CD4+ T cell death is not known. A fundamental issue is whether HIV-1 primarily induces direct killing of infected cells or indirectly causes death of uninfected bystander cells.
Baltimore, David, Chen, Benjamin K., Dale, Janet K., Gandhi, Rajesh T., Lenardo, Michael J., Straus, Stephen E.   +5 more
core   +2 more sources

Contribution of Gli1+ Adventitial Stem Cells to Smooth Muscle Cells in Atherosclerosis and Vascular Injury

Advanced Science, EarlyView.
Gli1+ adventitial stem cells (ASCs) have been thought to generate smooth muscle cells (SMCs) in atherosclerosis. Using a dual‐recombinase lineage tracing to exclude ectopic labeling, Wang et al. found that Gli1+ ASCs do not contribute to SMCs in atherosclerotic plaques.
Haixiao Wang, Xiuzhen Huang, Jialing Mou, Enci Wang, Yan Li, Wenjuan Pu, Yao Xie, Xiaoling Guo, Lixin Wang, Maoping Chu, Bin Zhou, Chao Niu   +11 more
wiley   +1 more source