Arthritis &Rheumatology, Accepted Article.Objectives Femoroacetabular impingement (FAI) and synovitis have been recognized as essential factors for developing osteoarthritis (OA) in the hip joints. However, little is known about altered synovial cellular compositions, their associated transcriptomic profiles, and cell‐cell interactions in FAI and hip OA.
Gulzada Kulzhanova +9 more
wiley +1 more source
Dysregulation of U12‐Type Splicing in Lupus Neutrophils
Arthritis &Rheumatology, Accepted Article.Abstract. Objective Neutrophil dysfunction is a hallmark of systemic lupus erythematosus (SLE), but its molecular basis remains unclear. This study explores transcriptional and post‐transcriptional changes in low‐density granulocytes (LDGs), a proinflammatory neutrophil subset expanded in SLE, focusing on NADPH oxidase (Nox) function and minor intron ...
Luz P. Blanco +11 more
wiley +1 more source
Health and Social Care Professionals' Perspectives of the Desired Interprofessional Collaboration in Frequent Attenders' Person-Centred Care: A Qualitative Study. [PDF]
Scand J Caring SciHartikainen K +4 more
europepmc +1 more source
Effect of the histone deacetylase inhibitor SNDX‐275 on Fas signaling in osteosarcoma cells and the feasibility of its topical application for the treatment of osteosarcoma lung metastases [PDF]
, 2011 Nadezhda V. Koshkina +2 more
openalex +1 more source
ToM2: Parental Perception of Theory of Mind Abilities in Autistic Children
Autism Research, EarlyView.ABSTRACT Understanding how parents perceive their children's abilities is crucial for family dynamics and intervention strategies, particularly in autism, where accurate parental assessment of social‐cognitive capabilities can influence support approaches and developmental outcomes. This study introduces ToM2, a novel measure examining parents' ability
Liraz Sasportas Joseph +3 more
wiley +1 more source
Influence of Different Death Receptor Signaling Pathways on Apoptosis of <i>Eimeria tenella</i> Host Cells. [PDF]
Curr Issues Mol BiolXu Z, Yu X, Ma J, Yu Y.
europepmc +1 more source
British Journal of Clinical Pharmacology, EarlyView.Abstract Aim Local investigators (LIs) overestimate the objective response rate (ORR) in comparison to Blinded Independent Central Reviewers (BICR) in oncology. In this study, we re‐analysed data obtained in the PHEREXA trial (NCT01026142) with the following aims: i) to confirm at the single‐patient level the discrepancy observed by analysing ...
Gennaro Daniele +3 more
wiley +1 more source
CMTM6 suppresses cell-surface expression of death receptor FAS in mice but not in humans. [PDF]
EMBO RepSemberova T +9 more
europepmc +1 more source
Efficacy, safety and cost‐effectiveness of CAR‐T therapy
British Journal of Clinical Pharmacology, EarlyView.CAR T‐cells demonstrate high efficacy in blood cancers, including ALL, MM and DLBCL. Innovations target solid tumours despite challenges such as antigen escape. Combination therapies enhance the delivery and infiltration of CAR T cells. Toxicity, cost and resistance remain major barriers to clinical use.
Emina Karahmet Sher +7 more
wiley +1 more source