Results 51 to 60 of about 622,986 (383)
lHuman cytotoxic T lymphocytes with reduced sensitivity to Fas-induced apoptosis [PDF]
, 2005 Effector-memory T cells expressing Fas (Apo-1/CD95) are switched to an apoptotic program by cross-linking with Fas-ligand (FasL). Consequently, tumors that express FasL can induce apoptosis of infiltrating Fas-positive T lymphocytes and subdue any ...
Biagi, E +8 more
core
Clinically Relevant Outcome Measures in Women With Adrenoleukodystrophy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Adrenoleukodystrophy is a rare inherited peroxisomal disease caused by pathogenic variants in the ABCD1 gene located on the X chromosome. Although the most severe central nervous system and adrenal complications typically affect only men with adrenoleukodystrophy, the majority of women develop myeloneuropathy symptoms in adulthood.
Chenwei Yan +3 more
wiley +1 more source
Beyond photoaging: additional factors involved in the process of skin aging
Clinical, Cosmetic and Investigational Dermatology, 2018 Flavia Alvim Sant’Anna Addor MEDCIN Research, Private Clinical Research Center, Osasco, São Paulo, Brazil Abstract: Studies assessing the impact of extrinsic factors on skin aging have increased during the last with the increase in life ...
Addor FAS
doaj
Lipid droplets and lipotoxicity during autophagy. [PDF]
, 2017 Lipid droplets (LDs) are neutral lipid storage organelles that provide a rapidly accessible source of fatty acids (FAs) for energy during periods of nutrient deprivation.
Nguyen, Truc, Olzmann, James
core +2 more sources
Fluid Biomarkers of Disease Burden and Cognitive Dysfunction in Progressive Supranuclear Palsy
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Identifying objective biomarkers for progressive supranuclear palsy (PSP) is crucial to improving diagnosis and establishing clinical trial and treatment endpoints. This study evaluated fluid biomarkers in PSP versus controls and their associations with regional 18F‐PI‐2620 tau‐PET, clinical, and cognitive outcomes.
Roxane Dilcher +10 more
wiley +1 more source
Geofísica InternacionalMexico City, one of the largest cities in the world, experiences frequent, devastating interplate earthquakes that originate on the subduction thrust along the Pacific coast of Mexico more than 250 km away.
Danny Arroyo, Mario Ordaz, Shri K Singh
doaj +1 more source
Romanian Journal of Laboratory Medicine, 2018 Background: Psoriasis is a multifactorial and inflammatory chronic skin disease indicated with T-cell-mediated keratinocyte hyper-proliferation. Demographic, epidemiological (family, twin), serological, and genetic studies have clearly demonstrated that ...
Duran Gülay Gülbol +4 more
doaj +1 more source
Fas-Fas Ligand System in Silicosis Patients.
Nippon Eiseigaku Zasshi (Japanese Journal of Hygiene), 2000 The exposure to silica and related substances such as silicate (e.g. chrysotile asbestos; 3MgO.2SiO2.H2O) or silicone (-R2Si-O-)n, used in plastic surgery, has been known to induce autoimmune diseases. The pathogenesis of autoimmunity induced by such environmental factors, however, needs to be clarified.
openaire +3 more sources
Caspase 8 activation independent of Fas (CD95/APO-1) signaling may mediate killing of B-chronic lymphocytic leukemia cells by cytotoxic drugs or gamma radiation. [PDF]
, 2001 Ligation of the cell-surface Fas molecule by its ligand (Fas-L) or agonistic anti-Fas monoclonal antibodies results in the cleavage and activation of the cysteine protease procaspase 8 followed by the activation of procaspase 3 and by apoptosis.
Folarin, NI +8 more
core
FAS-dependent cell death in α-synuclein transgenic oligodendrocyte models of multiple system atrophy [PDF]
, 2013 Multiple system atrophy is a parkinsonian neurodegenerative disorder. It is cytopathologically characterized by accumulation of the protein p25α in cell bodies of oligodendrocytes followed by accumulation of aggregated α-synuclein in so-called glial ...
Fillon, Gwenaëlle +13 more
core +3 more sources