Results 41 to 50 of about 123,724 (326)
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
BMC Immunology, 2023 Background Patients with Sjögren’s syndrome, like other patients with autoimmune disorders, display dysregulation in the function of their immune system. Fas and Fas Ligand (FasL) are among the dysregulated proteins. Methods We studied Fas and FasL on IL-
Irena Lindrova +9 more
doaj +1 more source
The Fas ligand/Fas system in renal injury [PDF]
Nephrology Dialysis Transplantation, 1999 The FasL-Fas system regulates renal cell apoptosis, as well as the immune and inflammatory responses. Evidence that FasL and Fas participate in renal injury may be summarized along modified Koch's postulates (Table 1): (i) FasL is expressed by renal cells and during renal injury, (ii) activation of the Fas receptor promotes apoptosis of cultured renal ...
A, Ortiz, C, Lorz, J, Egido
openaire +2 more sources
Uterine spiral artery remodeling involves endothelial apoptosis induced by extravillous trophoblasts through Fas/FasL interactions. [PDF]
, 2005 Objective— Invasion of uterine spiral arteries by extravillous trophoblasts in the first trimester of pregnancy results in loss of endothelial and musculoelastic layers.
Ashton, SV +6 more
core +1 more source
Functional characterization of a chimeric soluble Fas ligand polymer with in vivo anti-tumor activity. [PDF]
PLoS ONE, 2013 Binding of ligand FasL to its receptor Fas triggers apoptosis via the caspase cascade. FasL itself is homotrimeric, and a productive apoptotic signal requires that FasL be oligomerized beyond the homotrimeric state. We generated a series of FasL chimeras
Sophie Daburon +13 more
doaj +1 more source
Molecular manipulation of keratin 8/18 intermediate filaments: modulators of FAS-mediated death signaling in human ovarian granulosa tumor cells [PDF]
, 2016 Background: Granulosa cell tumors (GCT) are a rare ovarian neoplasm but prognosis is poor following recurrence. Keratin intermediate filaments expressed in these tumors are a diagnostic marker, yet paradoxically, may also constitute a target for ...
Davis, John S. +4 more
core +3 more sources
Natural killer cell response to chemotherapy-stressed cancer cells: Role in tumor immunosurveillance. [PDF]
, 2017 Natural killer (NK) cells are innate cytotoxic lymphoid cells that actively prevent neoplastic development, growth, and metastatic dissemination in a process called cancer immunosurveillance.
Borrelli, Cristiana +5 more
core +1 more source
Species difference in the expression of Fas and Fas ligand in mature mammalian spermatozoa
Czech Journal of Animal Science, 2017 Although it has been proposed that the Fas and Fas ligand (FasL) may protect ejaculated spermatozoa against apoptosis induced by lipoperoxidative damage and against lymphocytes present in the female genital tract, studies reported conflicting results on ...
Youwei Li +7 more
doaj +1 more source
Fas-ligand: Privilege and peril [PDF]
Proceedings of the National Academy of Sciences, 1997 Meanwhile, FasL was shown to play other roles in the body. As discussed in more detail below, activated cytotoxic T lymphocytes (and other cells) often express high levels of FasL and the ability of FasL to kill cells bearing Fas accounts for some destructive effects mediated by these cells.
D R, Green, C F, Ware
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FAS Ligand Triggers Pulmonary Silicosis [PDF]
The Journal of Experimental Medicine, 2001 We investigated the role of Fas ligand in murine silicosis. Wild-type mice instilled with silica developed severe pulmonary inflammation, with local production of tumor necrosis factor (TNF)-α, and interstitial neutrophil and macrophage infiltration in the lungs. Strikingly, Fas ligand–deficient generalized lymphoproliferative disease mutant (gld) mice
V M, Borges +13 more
openaire +2 more sources