Results 31 to 40 of about 598,280 (274)

Fas induces apoptosis in human coronary artery endothelial cells in vitro

BMC Cell Biology, 2004
Background Published work suggests that some types of endothelial cells undergo apoptosis in response to ligation of the receptor Fas (CD95, APO1) but other types are resistant.
Wang Rongqi, Dincer Erhan, Gidea Claudia, Ang Edmund, Filippatos Gerasimos, Uhal Bruce D   +5 more
doaj   +1 more source

Fas-Fas Ligand: checkpoint of T cell functions in multiple sclerosis

Frontiers in Immunology, 2016
Fas and Fas Ligand (FasL) are two molecules involved in regulation of cell death. Their interaction leads to apoptosis of thymocytes that fail to rearrange correctly their T cell receptor genes (TCR) and of those that recognize self-antigens, a process ...
Elisabetta Volpe, Manolo Sambucci, Luca Battistini, Giovanna Borsellino   +3 more
doaj   +1 more source

Uterine spiral artery remodeling involves endothelial apoptosis induced by extravillous trophoblasts through Fas/FasL interactions. [PDF]

, 2005
Objective— Invasion of uterine spiral arteries by extravillous trophoblasts in the first trimester of pregnancy results in loss of endothelial and musculoelastic layers.
Philip R. Dash, Cartwright, JE, Whitley, GS, Ashton, SV, Philip N. Baker, Crocker, IP, Baker, PN, Guy St. J. Whitley, Ian P. Crocker, Mark Wareing, Wareing, M, Sandra V. Ashton, Judith E. Cartwright, Dash, PR   +13 more
core   +1 more source

Transfer of Fas (CD95) protein from the cell surface to the surface of polystyrene beads coated with anti-Fas antibody clone CH-11

European Journal of Histochemistry, 2010
Mouse monoclonal anti-Fas (CD95) antibody clone CH-11 has been widely used in research on apoptosis. CH-11 has the ability to bind to Fas protein on cell surface and induce apoptosis.
H. Sawai, N. Domae
doaj   +1 more source

sFasL-mediated induction of neutrophil activation in patients with type 2 diabetes mellitus. [PDF]

PLoS ONE, 2018
Fas/Fas ligand system was shown to be related to insulin resistance and type 2 diabetes mellitus (T2DM). However, the role of soluble Fas ligand (sFasL) in functioning of immune cells in type 2 diabetes mellitus (T2DM) has not been studied yet.
Sona Margaryan, Agata Witkowicz, Arsen Arakelyan, Anna Partyka, Lidia Karabon, Gayane Manukyan   +5 more
doaj   +1 more source

Fas-ligand: Privilege and peril [PDF]

Proceedings of the National Academy of Sciences, 1997
Meanwhile, FasL was shown to play other roles in the body. As discussed in more detail below, activated cytotoxic T lymphocytes (and other cells) often express high levels of FasL and the ability of FasL to kill cells bearing Fas accounts for some destructive effects mediated by these cells.
D R, Green, C F, Ware
openaire   +2 more sources

Polymorphism of FAS and FAS ligand genes in alopecia areata: A case–control study in Egyptian population

Indian Journal of Dermatology, 2018
Background: Alopecia areata (AA) is a common dermatologic disease with suspected autoimmune etiology. Tumor necrosis factor superfamily member 6 or CD95 (FAS) and FAS ligand (FASL) are proapoptotic proteins.
Iman Seleit, Ola Ahmed Bakry, Eman Abd El Gayed, Abd El Gawad D   +3 more
doaj   +1 more source

Unsolved mystery of Fas: mononuclear cells may have trouble dying in patients with Sjögren’s syndrome

BMC Immunology, 2023
Background Patients with Sjögren’s syndrome, like other patients with autoimmune disorders, display dysregulation in the function of their immune system. Fas and Fas Ligand (FasL) are among the dysregulated proteins. Methods We studied Fas and FasL on IL-
Irena Lindrova, Martina Kolackova, Tereza Svadlakova, Radka Vankova, Marcela Chmelarova, Michaela Rosecka, Eva Jozifkova, Martin Sembera, Jan Krejsek, Radovan Slezak   +9 more
doaj   +1 more source

CD40 ligand induced cytotoxicity in carcinoma cells is enhanced by inhibition of metalloproteinase cleavage and delivery via a conditionally-replicating adenovirus [PDF]

, 2010
Background CD40 and its ligand (CD40L) play a critical role in co-ordinating immune responses. CD40 is also expressed in lymphoid malignancies and a number of carcinomas. In carcinoma cells the physiological outcome of CD40 ligation depends on the level
Young Lawrence S, Elmetwali, Taha, Mcneish, I., Searle Peter F, Young, Lawrence, Searle, PF, Palmer Daniel H, McNeish, I, Young, Lawrence S., Palmer, D.H., McNeish, Iain, Peter F Searle, Lawrence S Young, Elmetwali, T., Searle, P.F., Elmetwali Taha, Iain McNeish, Young, LS, McNeish Iain, Palmer, Daniel H., Palmer, DH, Searle, Peter F., Daniel H Palmer, Young, L.S., Taha Elmetwali, Palmer, Daniel, Searle, Peter, Elmetwali, T   +27 more
core   +1 more source

Fas-mediated apoptosis and peripheral polyneuropathy in type 2 diabetes mellitus

Egyptian Rheumatology and Rehabilitation, 2019
Objective To evaluate the role of soluble Fas (sFas) and soluble Fas ligand (sFasL) in the pathogenesis of distal symmetrical polyneuropathy (DSPN) in patients with type 2 diabetes mellitus, and to analyze the relationship between these apoptotic markers
Mowaffak M Abd Elhameed, Noha A Elsawy, Magdy H Zekry Mgalaa, Sarah S El-Tawab, Reham A Abo Elwafa, Marwa R Abd Elfadeel   +5 more
doaj   +1 more source