Results 31 to 40 of about 59,326 (211)

sFasL-mediated induction of neutrophil activation in patients with type 2 diabetes mellitus. [PDF]

PLoS ONE, 2018
Fas/Fas ligand system was shown to be related to insulin resistance and type 2 diabetes mellitus (T2DM). However, the role of soluble Fas ligand (sFasL) in functioning of immune cells in type 2 diabetes mellitus (T2DM) has not been studied yet.
Sona Margaryan, Agata Witkowicz, Arsen Arakelyan, Anna Partyka, Lidia Karabon, Gayane Manukyan   +5 more
doaj   +1 more source

Expression of Fas ligand in retinoblastoma [PDF]

Cancer, 2004
AbstractBACKGROUNDThe importance of the Fas‐Fas ligand (FasL) mechanism for the immune evasion by tumors provided a strong rationale for the examination of FasL expression in retinoblastoma. In an earlier publication, the authors reported that invasive retinoblastomas decreased Fas expression.
Subramanian, Krishnakumar, Mallikarjuna, Kandalam, Adithi, Mohan, Anita, Iyer, Nalini, Venkatesan, Jyotirmay, Biswas, Mahesh Palanivelu, Shanmugam   +6 more
openaire   +2 more sources

Periodontal diseases and adverse pregnancy outcomes. Present and future

Periodontology 2000, EarlyView., 2023
Abstract For more than two decades the possible association between periodontal diseases and adverse pregnancy outcomes has been extensively evaluated. Numerous observational, intervention, and mechanistic studies have offered valuable information on this topic.
Yiorgos A. Bobetsis, Mark Ide, Mervi Gürsoy, Phoebus N. Madianos   +3 more
wiley   +1 more source

Fas-mediated apoptosis and peripheral polyneuropathy in type 2 diabetes mellitus

Egyptian Rheumatology and Rehabilitation, 2019
Objective To evaluate the role of soluble Fas (sFas) and soluble Fas ligand (sFasL) in the pathogenesis of distal symmetrical polyneuropathy (DSPN) in patients with type 2 diabetes mellitus, and to analyze the relationship between these apoptotic markers
Mowaffak M Abd Elhameed, Noha A Elsawy, Magdy H Zekry Mgalaa, Sarah S El-Tawab, Reham A Abo Elwafa, Marwa R Abd Elfadeel   +5 more
doaj   +1 more source

Unsolved mystery of Fas: mononuclear cells may have trouble dying in patients with Sjögren’s syndrome

BMC Immunology, 2023
Background Patients with Sjögren’s syndrome, like other patients with autoimmune disorders, display dysregulation in the function of their immune system. Fas and Fas Ligand (FasL) are among the dysregulated proteins. Methods We studied Fas and FasL on IL-
Irena Lindrova, Martina Kolackova, Tereza Svadlakova, Radka Vankova, Marcela Chmelarova, Michaela Rosecka, Eva Jozifkova, Martin Sembera, Jan Krejsek, Radovan Slezak   +9 more
doaj   +1 more source

Functional characterization of a chimeric soluble Fas ligand polymer with in vivo anti-tumor activity. [PDF]

PLoS ONE, 2013
Binding of ligand FasL to its receptor Fas triggers apoptosis via the caspase cascade. FasL itself is homotrimeric, and a productive apoptotic signal requires that FasL be oligomerized beyond the homotrimeric state. We generated a series of FasL chimeras
Sophie Daburon, Christel Devaud, Pierre Costet, Aurore Morello, Laure Garrigue-Antar, Mike Maillasson, Nathalie Hargous, Delphine Lapaillerie, Marc Bonneu, Julie Dechanet-Merville, Patrick Legembre, Myriam Capone, Jean-François Moreau, Jean-Luc Taupin   +13 more
doaj   +1 more source

Fas ligand, death gene [PDF]

Cell Death & Differentiation, 1999
The concept of death genes goes back to the early days of programmed cell death, when a researcher's model system was required to be dependent on transcription of the dying cell in order to qualify as apoptosis. In 1987 Andrew Wyllie,1 one of the pioneers of cell death research, outlined four 'cardinal elements' of apoptosis: one of which was a ...
M J, Pinkoski, D R, Green
openaire   +2 more sources

Species difference in the expression of Fas and Fas ligand in mature mammalian spermatozoa

Czech Journal of Animal Science, 2017
Although it has been proposed that the Fas and Fas ligand (FasL) may protect ejaculated spermatozoa against apoptosis induced by lipoperoxidative damage and against lymphocytes present in the female genital tract, studies reported conflicting results on ...
Youwei Li, Mingju Sun, Jiang Zhu, Guangzhong Jiao, Juan Lin, Haibo Dong, Jinghe Tan, Jiabo Zhou   +7 more
doaj   +1 more source

Lymphoid‐Tissue‐on‐Chip Recapitulates Human Antibody Responses In Vitro

Advanced Science, EarlyView.
The presented lymphoid‐tissue‐on‐chip system allows culture of primary human tonsil cells at organotypic high density under perfusion for up to 4 weeks, emulates immune response to soluble vaccines and vaccination via peripheral antigen‐presenting cells and represents a useful tool to assess cellular interactions during homeostasis, immune responses ...
Claudia Teufel, Anna‐Sophie Schlemmer, Andrea W. Eiken, Zachary W. Wagoner, Dennis Vöhringer, Lena Christ, Alex Dulovic, Patrick Marsall, Madeleine Fandrich, Eduardo J. S. Brás, Julia Marzi, Friederike Bärhold, Julia Philipp, Sven Becker, Lisa E. Wagar, Peter Loskill   +15 more
wiley   +1 more source

The Fas and Fas ligand pathways in liver allograft tolerance [PDF]

Clinical and Experimental Immunology, 1999
SUMMARY The Fas and Fas ligand (Fas/FasL) pathways may play a central role in cytotoxicity or immunoregulation in liver transplantation. Here, in an attempt to examine the role of Fas/FasL on drug-free tolerance, we measured mRNA levels of Fas/FasL in livers by reverse transcriptase-polymerase chain reaction (RT-PCR), and also protein ...
T L, Pan, S, Goto, Y C, Lin, R, Lord, K C, Chiang, C Y, Lai, Y S, Chen, H L, Eng, Y F, Cheng, T, Tatsuma, S, Kitano, C L, Lin, C L, Chen   +12 more
openaire   +2 more sources