Results 41 to 50 of about 1,159,722 (286)

Functional characterization of a chimeric soluble Fas ligand polymer with in vivo anti-tumor activity. [PDF]

PLoS ONE, 2013
Binding of ligand FasL to its receptor Fas triggers apoptosis via the caspase cascade. FasL itself is homotrimeric, and a productive apoptotic signal requires that FasL be oligomerized beyond the homotrimeric state. We generated a series of FasL chimeras
Sophie Daburon, Christel Devaud, Pierre Costet, Aurore Morello, Laure Garrigue-Antar, Mike Maillasson, Nathalie Hargous, Delphine Lapaillerie, Marc Bonneu, Julie Dechanet-Merville, Patrick Legembre, Myriam Capone, Jean-François Moreau, Jean-Luc Taupin   +13 more
doaj   +1 more source

Chelation Drives Surface Substitution in Hybrid‐MXenes

Angewandte Chemie, EarlyView.
We demonstrate ethylenediamine‐derived bidentate binding on Ti3C2 by controlled deprotonation of ─NH2 groups during reaction with Ti3C2Br2. XRD, XPS, ssNMR, STEM, DFT, and INS confirm the bidentate coordination and the superior stability of chelating modes, while AIMD reveals proton transfer and new surface imine–Ti bonding mode.
Vikash Khokhar, Young‐Hwan Kim, Abu Rashed Md. Shawon, Fatemeh Karimi, Danial Zangeneh, Yongqiang Cheng, Chang Liu, Murillo Longo Martins, Alexander S. Filatov, Robert F. Klie, Aaron J. Rossini, John S. Anderson, Dmitri V. Talapin, De‐en Jiang   +13 more
wiley   +2 more sources

Fas-ligand and caspase-3 positivity in three cases of histiocytic sarcoma: a different etiopathogenic pathway?

Autopsy and Case Reports, 2018
Histiocytic sarcoma (HS) is a rare malignant neoplasia of hematopoietic origin and unknown etiology. We studied three patients with histiocytic sarcoma reviewing the morphological and immunohistochemical aspects.
Cristiano Claudino Oliveira, Rafael Bispo Paschoalini, Maria Aparecida Custódio Domingues   +2 more
doaj   +1 more source

Fas ligand, death gene [PDF]

Cell Death & Differentiation, 1999
The concept of death genes goes back to the early days of programmed cell death, when a researcher's model system was required to be dependent on transcription of the dying cell in order to qualify as apoptosis. In 1987 Andrew Wyllie,1 one of the pioneers of cell death research, outlined four 'cardinal elements' of apoptosis: one of which was a ...
M J, Pinkoski, D R, Green
openaire   +2 more sources

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Species difference in the expression of Fas and Fas ligand in mature mammalian spermatozoa

Czech Journal of Animal Science, 2017
Although it has been proposed that the Fas and Fas ligand (FasL) may protect ejaculated spermatozoa against apoptosis induced by lipoperoxidative damage and against lymphocytes present in the female genital tract, studies reported conflicting results on ...
Youwei Li, Mingju Sun, Jiang Zhu, Guangzhong Jiao, Juan Lin, Haibo Dong, Jinghe Tan, Jiabo Zhou   +7 more
doaj   +1 more source

Metalloproteinase-mediated release of human Fas ligand

Journal of Experimental Medicine, 1995
Fas ligand (FasL) is a type II integral membrane protein homologous with tumor necrosis factor (TNF). Recent studies indicate that TNF is processed to yield the soluble cytokine by metalloproteinases at the cell surface of activated macrophages and T ...
A. Kawasaki, T. Ebata, H. Ohmoto, Shoji Ikeda, S. Inoue, Koichiroyoshino, Ko Okumura   +6 more
semanticscholar   +1 more source

Engineering Approaches to Modify Immunomodulatory Functions of Mesenchymal Stromal Cells (MSCs): Tissue Regeneration and Clinical Application

Advanced Science, EarlyView.
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang, Kejia Li, Ning Wang, Zhen Li, Zhiyong Zhang, Rocky S. Tuan, Yangzi Jiang   +6 more
wiley   +1 more source

Multiferroic‐Centric Materials and Systems Engineering for Battery Applications: An Insight Into Mechanisms, Strategies, and Characterizations

Advanced Science, EarlyView.
Multiferroic order parameters – polarization, magnetization, and ferroelastic strain – are positioned as dynamic design variables for batteries. Their mechanistic roles, practical tuning through fabrication and external fields, and ferroic‐resolved characterization routes are unified into a closed‐loop framework, revealing how coupled ferroic responses
Jiaqi Su, Yanda Zhu, Hao Peng, Manman Li, Xuzihan Zhang, Meixiao Wu, Siyuan Zhang, Yuhan Zeng, Jiwen Liao, Ming Luo, Hetaishan Huang, Yutong Wang, Sean Li, Wenxian Li   +13 more
wiley   +1 more source

The Fas and Fas ligand pathways in liver allograft tolerance [PDF]

Clinical and Experimental Immunology, 1999
SUMMARY The Fas and Fas ligand (Fas/FasL) pathways may play a central role in cytotoxicity or immunoregulation in liver transplantation. Here, in an attempt to examine the role of Fas/FasL on drug-free tolerance, we measured mRNA levels of Fas/FasL in livers by reverse transcriptase-polymerase chain reaction (RT-PCR), and also protein ...
T L, Pan, S, Goto, Y C, Lin, R, Lord, K C, Chiang, C Y, Lai, Y S, Chen, H L, Eng, Y F, Cheng, T, Tatsuma, S, Kitano, C L, Lin, C L, Chen   +12 more
openaire   +2 more sources