FAS Ligand, Bcl-2, Granulocyte Colony-Stimulating Factor, and p38 Mitogen-Activated Protein Kinase [PDF]
The Journal of Experimental Medicine, 2000 The short life span of granulocytes, which limits many inflammatory responses, is thought to be influenced by the Bcl-2 protein family, death receptors such as CD95 (Fas/APO-1), stress-activated protein kinases such as p38 mitogen-activated protein kinase (MAPK), and proinflammatory cytokines like granulocyte colony-stimulating factor (G-CSF).
Andreas Villunger +4 more
openaire +1 more source
Signaling pathways for transduction of the initial message of the glycocode into cellular responses [PDF]
, 1998 The sugar units of glycan structures store information and establish an alphabet of life. The language of the oligosaccharide coding units is deciphered by receptors such as lectins and the decoded message can be transduced by multiple signaling pathways.
Gabius, Hans-Joachim, Villalobo, A.
core +2 more sources
TRAIL receptor signaling regulation of chemosensitivity in vivo but not in vitro. [PDF]
PLoS ONE, 2011 Signaling by Tumor Necrosis Factor-Related Apoptosis Inducing Ligand (TRAIL) and Fas ligand (FasL) has been proposed to contribute to the chemosensitivity of tumor cells treated with various other anti-cancer agents.
Christina Menke +6 more
doaj +1 more source
Effect of Insulin-Like Growth Factor-1 (IGF-1) on the expression of NFκB and cFLIP in Bovine Granulosa Cells [PDF]
, 2014 Infertility, often attributed to follicular atresia, is a growing problem in the agricultural industry. Programmed cell death, also known as apoptosis, is a contributing factor of follicular atresia.
Docos, Samantha Kathleen
core +1 more source
The effect of experimental hyperoxia on erythrocytes’ oxygen-transport function [PDF]
, 2018 The aim of this study was to investigate the effect of hyperoxia, calcium ions and pH value on the composition of major phospholipids in human erythrocyte membranes and erythrocytes’ oxygen-transport function. To create a model of hyperoxia, we saturated
Alexander Alexandrovich Moskovkin +25 more
core +4 more sources
Cytokines and chemokines as regulators of skeletal muscle inflammation: presenting the case of Duchenne muscular dystrophy [PDF]
, 2013 Duchenne muscular dystrophy is a severe inherited muscle disease that affects 1 in 3500 boys worldwide. Infiltration of skeletal muscle by inflammatory cells is an important facet of disease pathophysiology and is strongly associated with disease ...
De Bleecker, Jan, De Paepe, Boel
core +3 more sources
Babao Dan induces gastric cancer cell apoptosis via regulating MAPK and NF-κB signaling pathways
Journal of International Medical Research, 2019 Objective The objective was to further investigate apoptosis induction by Babao Dan (BBD), which supports its anti-tumor mechanisms, using two human gastric cancer cell lines (AGS and MGC80-3).
Haixia Shang +9 more
doaj +1 more source
Journal of Lipid Research, 2014 Adipose TG lipase (ATGL) catalyzes the rate-limiting step in TG hydrolysis in most tissues. We have shown that hepatic ATGL preferentially channels hydrolyzed FAs to β-oxidation and induces PPAR-α signaling.
Kuok Teong Ong +3 more
doaj +1 more source
Serum Fas/FasL levels in dependence on clinical presentations of coronary disease and their relationship with risk factors [PDF]
Vojnosanitetski Pregled, 2010 Background/Aim. Ischemic heart disease is mostly a consequence of atherosclerosis. Besides the inflammation, the Fas/Fas ligand (FasL)/caspase death pathway is documented to be activated in atherosclerotic lesions.
Ristić Tatjana +4 more
doaj +1 more source
Direct interaction between EgFABP1, a fatty acid binding protein from echinococcus granulosus, and phospholipid membranes [PDF]
, 2012 <p>Background: Growth and maintenance of hydatid cysts produced by Echinococcus granulosus have a high requirement for host lipids for biosynthetic processes, membrane building and possibly cellular and developmental signalling.
Alvite, G. +5 more
core +5 more sources