Results 11 to 20 of about 97,027 (306)
Fas and Fas ligand are highly expressed in lymphocytes from cervical intraepithelial neoplasia and cervical cancer patients: A possible role for immune escaping [PDF]
Iranian Journal of Basic Medical Sciences, 2022 Objective(s): Infection with high-risk human papillomavirus is required to develop cervical cancer. Some viruses modulate the Fas/FasL signaling to evade the immune response; the role of these molecules in cervical cancer is not clear.
Carla O Contreras-Ochoa +7 more
doaj +1 more source
FAS (Fas cell surface death receptor) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2017 CD95 (also known as Fas) is a death receptor that belongs to the TNF-receptor superfamily. Expressed at the cell surface as a homotrimer, this receptor implements both apoptotic and non-apoptotic signalling pathways. While the apoptotic signalling pathway is involved in tumor surveillance, peripheral tolerance and immune homeostasis (Strasser et al ...
Sanséau, Doriane, Legembre, Patrick
openaire +2 more sources
Cells, 2022 Signaling through the TNF-family receptor Fas/CD95 can trigger apoptosis or non-apoptotic cellular responses and is essential for protection from autoimmunity.
Nicholas Frazzette +6 more
doaj +1 more source
Cholangiocarcinomas express fas ligand and disable the fas receptor [PDF]
Hepatology, 1999 Cholangiocarcinoma is a highly-malignant adenocarcinoma originating from cholangiocytes. Current concepts support escape from immune surveillance using aberrant expression of Fas ligand (FasL) and dysregulation of receptor (FasR) signaling as a potential mechanism for tumor progression.
F G, Que +6 more
openaire +2 more sources
Frontiers in Pediatrics, 2022 BackgroundThe autoimmune lymphoproliferative syndrome (ALPS) is a rare disease characterized by defective function of the FAS death receptor, which results in chronic, non-malignant lymphoproliferation and autoimmunity accompanied by elevated numbers of ...
Hao Gu +7 more
doaj +1 more source
Soluble Fas ligand drives autoantibody-induced arthritis by binding to DR5/TRAIL-R2
eLife, 2021 To date, no study has demonstrated that soluble Fas ligand (sFasL)-mediated inflammation is regulated via interaction with Fas in vivo. We found that FasL interacts specifically with tumor necrosis factor receptor superfamily (TNFRSF)10B, also known as ...
Dongjin Jeong +15 more
doaj +1 more source
MK2 and Fas receptor contribute to the severity of CNS demyelination. [PDF]
PLoS One, 2014 Tietz SM +5 more
europepmc +3 more sources
Functional characterization of a chimeric soluble Fas ligand polymer with in vivo anti-tumor activity. [PDF]
PLoS ONE, 2013 Binding of ligand FasL to its receptor Fas triggers apoptosis via the caspase cascade. FasL itself is homotrimeric, and a productive apoptotic signal requires that FasL be oligomerized beyond the homotrimeric state. We generated a series of FasL chimeras
Sophie Daburon +13 more
doaj +1 more source
Pro- and anti-apoptotic fate decisions induced by di- and trimeric synthetic cytokine receptors
iScience, 2021 Summary: Synthetic strategies to activate cytokine receptors so far only address standard dimeric cytokine receptor assemblies. The 19 ligands of the tumor necrosis factor superfamily (TNFSF), however, form noncovalent trimers and receptor trimerization ...
Sofie Mossner +2 more
doaj +1 more source