Results 191 to 200 of about 185,643 (306)

MK2 and Fas receptor contribute to the severity of CNS demyelination. [PDF]

PLoS One, 2014
Tietz SM, Hofmann R, Thomas T, Tackenberg B, Gaestel M, Berghoff M.   +5 more
europepmc   +1 more source

Bioinorganic Site‐Specific Conjugation of Multi‐Arm Linkers to Create Pharmaceuticals With Targeting and Effector Functions

Journal of the Chinese Chemical Society, EarlyView.
This Account showcases a modular, multi‐arm linker platform that decouples payload loading from antibody conjugation. By leveraging a computationally designed ACPGHA zinc‐binding motif, we demonstrate the construction of homogeneous antibody‐drug conjugates and theranostic antibody‐radionuclide conjugates with high payload loading. The multi‐arm linker
Cédric Grauffel, Tse Wen Chang, Carmay Lim   +2 more
wiley   +1 more source

A MR Fingerprinting Development Kit for Quantitative 3D Brain Imaging

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Magnetic resonance fingerprinting (MRF) is an emerging quantitative imaging technique that enables multiparametric tissue characterization, but its adoption has been hindered by the complexity of data acquisition and post‐processing. These technical and implementation challenges have limited its broader clinical deployment.
Rasim Boyacioglu, Thomas Kluge, Guido Buonincontri, Wei‐Ching Lo, Stephan Kannengiesser, Mathias Nittka, Arashdeep Kaur, Andrew Dupuis, Dan Ma, Chaitra Badve, Mark A. Griswold, Yong Chen   +11 more
wiley   +1 more source

CMTM6 suppresses cell-surface expression of death receptor FAS in mice but not in humans. [PDF]

EMBO Rep
Semberova T, Pribikova M, Cimermanova V, Trivic T, Haderbache R, Paprckova D, Christen L, Kissiova H, Stepanek O, Draber P.   +9 more
europepmc   +1 more source

Retinal de novo lipogenesis coordinates neurotrophic signaling to maintain vision [PDF]

, 2018
Adak, Sangeeta, Chen, Shiming, Doggett, Teresa, Enright, Jennifer, Hsu, Fong-Fu, Ling, Guoyu, Rajagopal, Rithwick, Semenkovich, Clay F, Shah, Vaishali, Wei, Xiaochao, Yoshino, Jun, Zhang, Sheng   +11 more
core   +2 more sources

Managing Spectral Intensity Variations With In‐Line Fiber‐Optic High‐Volume Noncontact Raman Probes: A Strategy Exploration

Journal of Raman Spectroscopy, EarlyView.
Robust quantification in noncontact Raman sensing requires dedicated correction of working distance dependent background effects, while laser power variations are readily stabilized using internal reference signals. Chemically relevant Raman intensity can be preserved for bulk composition measurements, under variable laser power and working distance ...
Tiril Aurora Lintvedt, Petter Vejle Andersen, Jens Petter Wold, Nils Kristian Afseth   +3 more
wiley   +1 more source

The Mediating Factor of Immune Cell in the Causal Relationship Between Cardiovascular Disease-Related Plasma Proteins and Parkinson's Disease: A Network Mendelian Randomization Analysis. [PDF]

Mediators Inflamm
Yao R, Chen S, Lu Y, Li Y, Yu B, Liu Y, Zhang T, Zhu Y, Chen F, Lin Y, Wang Y, Li C.   +11 more
europepmc   +1 more source

Real‐World, Prospective, Multicenter Outcomes to Brodalumab Treatment in Patients With Moderate‐to‐Severe Psoriasis in Greece (The RESOLVE Study)

JEADV Clinical Practice, EarlyView.
RESOLVE was a prospective, real‐world study in patients with moderate‐to‐severe psoriasis treated with brodalumab. At Week 12, 76.4% achieved PASI ≤ 3, 53.5% PASI100, and 71.5%/54.2% achieved sPGA0/1 and sPGA 0, respectively. At Week 52, 96.1% achieved sPGA success (clear/almost clear). Furthermore, at Week 52, mean DLQI scores decreased by 12.6 ± 6.2,
Electra Nicolaidou, Pantelis Panagakis, Dimitrios Xekardakis, Natalia Rompoti, Marina Papoutsaki, Ioanna Lefaki, Kanella Kalapothakou, Despina Exadactylou, Athanasios Chaniotis, Vasiliki Chasapi, Alexander Stratigos   +10 more
wiley   +1 more source

Association of FAS gene polymorphisms with the risk of noise-induced hearing loss in Chinese occupational workers. [PDF]

Front Public Health
Li YH, Jiang PS, Bai LX, Xie CJ, Zhao Y, Li Q, Zeng WF, Zhu F.   +7 more
europepmc   +1 more source

Clinically Meaningful Improvements in Quality of Life, Including Sleep, With Two‐Week and Monthly Dosed Rademikibart: A Phase 2 Randomized Trial in Adults With Moderate‐to‐Severe Atopic Dermatitis

JEADV Clinical Practice, EarlyView.
Rademikibart, a potent IL‐4Rα‐targeting antibody, achieved its primary endpoint as a treatment for adults with moderate‐to‐severe atopic dermatitis (AD) in the CBP‐201‐WW001 Phase 2 trial. There is a need for AD treatment options with convenient dosing intervals.
Jonathan I. Silverberg, Emma Guttman‐Yassky, Raúl Collazo   +2 more
wiley   +1 more source