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Necrotic death pathway in Fas receptor signaling
Necrotic death pathway in Fas receptor signalingopenaire
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Inhibition of Fas Receptor Endocytosis Sensitizes Cancer Cells to Fas-induced Apoptosis
European Journal of Cancer, 2022AbstractFas (CD95/APO-1) is a transmembrane death receptor that transduces apoptotic signals upon binding to its ligand and assembling into a death-inducing signaling complex (DISC) (1, 2). Intracellular trafficking of Fas receptors, including recycling from endosomes to the plasma membrane, plays a vital role in ligand-induced assembly of DISC (3, 4).
Mehmet H. Kural +9 more
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Fas ligand: receptor or ligand?
Apoptosis, 1999In this review, we chronicle the discovery, biochemical characterization, and assignment of Fas (CD95) as receptor and Fas Ligand (FasL, CD95L) as ligand. We review the functional descriptions of the molecules as death-inducing receptor and ligand or as mediators of cell division and/or growth arrest.
M K, Newell, J, Desbarats
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Fas receptor expression on B‐lineage cells
European Journal of Immunology, 1995AbstractMice homozygous for the lpr mutation have B and T cell defects and develop autoantibodies, suggesting that lpr plays a role in their genesis. The lpr defect has been identified as a mutation in the apoptosis‐associated Fas receptor (FasR) gene.
L, Mandik, K A, Nguyen, J, Erikson
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Fas receptor‐mediated apoptosis: a clinical application?
The Journal of Pathology, 2001AbstractFas is a membrane protein belonging to the death receptor family. Cross‐linking of Fas by its ligand, FasL, or agonistic anti‐Fas antibodies, induces apoptosis of cells expressing Fas on the membrane by triggering a cascade of caspases. Since many different tumours express Fas on their membrane, targeting Fas‐mediated apoptosis by anti‐Fas ...
Tineke, Timmer +2 more
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Fas Receptor (CD95)-Mediated Apoptosis in Leukemic Cells
Leukemia & Lymphoma, 1997Binding of Fas ligand (FasL) or an agonistic anti-Fas receptor (Fas/CD95) antibody induces apoptosis in Fas-bearing target cells. The involvement of Fas/FasL pathway has been investigated in human acute myelogenous leukemia (AML) cells. Fas/CD95 is expressed on a majority of AML cells, although the intensity of expression is variable. The cross-linking
Y, Komada, M, Sakurai
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Phosphorylation-Based Signaling in Fas Receptor-Mediated Apoptosis
Critical Reviews™ in Immunology, 2000Apoptosis or programmed cell death plays an essential role during development of the immune system, in immune responses, and in the control of tissue homeostasis in the adult. An important physiological mediator of apoptosis is the Fas/APO-1/CD95 receptor (FasR), a surface receptor belonging to the tumor necrosis factor receptor family.
T H, Holmström, J E, Eriksson
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TUMOR NECROSIS FACTOR RECEPTOR AND Fas SIGNALING MECHANISMS
Annual Review of Immunology, 1999▪ Abstract Four members of the tumor necrosis factor (TNF) ligand family, TNF-α, LT-α, LT-β, and LIGHT, interact with four receptors of the TNF/nerve growth factor family, the p55 TNF receptor (CD120a), the p75 TNF receptor (CD120b), the lymphotoxin beta receptor (LTβR), and herpes virus entry mediator (HVEM) to control a wide range of innate and ...
D, Wallach +5 more
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Prognostic significance of the Fas-receptor/Fas-ligand system in cervical squamous cell carcinoma
Virchows Archiv, 2007We studied whether Fas-receptor (Fas-R; CD95) expression, single-nucleotide polymorphisms (SNPs) in the Fas promoter region, and/or Fas-ligand (Fas-L) production could determine individual susceptibility to cervical cancer progression. The clinicopathologic features of 38 patients with cervical squamous carcinomas (22 stage I, 8 stage II, and 8 stage ...
Enrique, Lerma +8 more
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Death receptors, Fas and TRAIL receptors, are involved in human osteoclast apoptosis
Biochemical and Biophysical Research Communications, 2005Survival and apoptosis are crucial aspects of the osteoclast life cycle. Although osteoclast survival has been extensively studied, little is known about the mechanisms involved in human osteoclast apoptosis. In the present study, cord blood monocytes (CBMs) were used as the source of human osteoclast precursors.
Sophie, Roux +5 more
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