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In Vivo Inhibition of Fas Ligand-Mediated Killing by TR6, a Fas Ligand Decoy Receptor
The Journal of Pharmacology and Experimental Therapeutics, 2001TR6, a member of the tumor necrosis factor (TNF) receptor superfamily, has recently been shown to bind to Fas ligand (FasL) and inhibit FasL-mediated cell killing in vitro. In the current study, we demonstrate that TR6 can block the lethal activity of FasL in multiple in vitro systems, and extend this finding to an in vivo model of hepatitis.
K, Connolly +16 more
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The Protein Journal, 2016
The Fas receptor is a representative death receptor, and the Fas-associated protein with death domain (FADD) is a crucial adapter protein needed to support the Fas receptor's activity. The Fas-FADD interactions constitute an important signaling pathway that ultimately induces apoptosis or programmed cell death in biological systems.
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The Fas receptor is a representative death receptor, and the Fas-associated protein with death domain (FADD) is a crucial adapter protein needed to support the Fas receptor's activity. The Fas-FADD interactions constitute an important signaling pathway that ultimately induces apoptosis or programmed cell death in biological systems.
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Prognostic significance of the Fas-receptor/Fas-ligand system in cervical squamous cell carcinoma
Virchows Archiv, 2007We studied whether Fas-receptor (Fas-R; CD95) expression, single-nucleotide polymorphisms (SNPs) in the Fas promoter region, and/or Fas-ligand (Fas-L) production could determine individual susceptibility to cervical cancer progression. The clinicopathologic features of 38 patients with cervical squamous carcinomas (22 stage I, 8 stage II, and 8 stage ...
Enrique, Lerma +8 more
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Fas receptor-mediated apoptosis
The Journal of Pathology, 2002Fas is a membrane protein belonging to the death receptor family. Cross-linking of Fas by its ligand, FasL, or agonistic anti-Fas antibodies, induces apoptosis of cells expressing Fas on the membrane by triggering a cascade of caspases. Since many different tumours express Fas on their membrane, targeting Fas-mediated apoptosis by anti-Fas antibodies ...
Timmer, T, de Vries, EGE, de Jong, S
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Phosphorylation-Based Signaling in Fas Receptor-Mediated Apoptosis
Critical Reviews™ in Immunology, 2000Apoptosis or programmed cell death plays an essential role during development of the immune system, in immune responses, and in the control of tissue homeostasis in the adult. An important physiological mediator of apoptosis is the Fas/APO-1/CD95 receptor (FasR), a surface receptor belonging to the tumor necrosis factor receptor family.
T H, Holmström, J E, Eriksson
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Defining the dynamics of self-assembled Fas-receptor activation
Trends in Immunology, 2002Fas-Fas-ligand, the most well investigated apoptotic signaling system, plays a pivotal role in several human diseases. Its signaling through multiple pathways; multiple, complex regulatory points; and recently described tendency to undergo ligand-independent self-assembly warrant a comprehensive understanding of its physiologically well controlled ...
Suneel D, Mundle, Azra, Raza
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Fas receptor expression on asthmatic eosinophils.
Research communications in molecular pathology and pharmacology, 1999Activation of the Fas receptor (Fas; CD95) on eosinophils induces apoptosis and may play a role in controlling eosinophil number in blood and tissue. To determine whether Fas expression on eosinophils is different between asthmatics and non-asthmatics, eosinophils were isolated from the peripheral blood using a three-step procedure of dextran ...
J E, Fahy +3 more
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Fas receptor signaling is requisite for B cell differentiation
Journal of Leukocyte Biology, 2005AbstractThe Fas/Fas ligand (FasL) pathway has been largely implicated in the homeostasis of mature cells. However, it is still unclear whether it plays a role at the progenitor level. To address this issue, we created chimeric mice by transferring C57BL/6 bone marrow (BM) cells of the lpr (Fas−FasL+) or gld (Fas+FasL−) genotype into Rag-2−/− hosts of ...
Pasqualetto, Valérie +4 more
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The role of the Fas receptor in adipocyte metabolism
2010Fas (FasR, CD95, Apo-1) is a member of the tumour necrosis receptor superfamily and plays a crucial role in the induction of apoptosis. In addition, depending on the cell type, activation of Fas can also induce non-apoptotic signalling pathways, including inflammation and proliferation.
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Analysis of Tyr to Phe and fa/fa leptin receptor mutations in the PC12 cell line.
European cytokine network, 1999Weight regulation through body-fat content and energy homeostasis, is regulated mainly through the actions of leptin. Herein, we analyse the effect of mutations in the mouse leptin receptor using the PC12 pheochromocytoma cell line as a model system. Both the induction of pancreatitis associated protein 1 and metallothionein-II, two leptin regulated ...
Eyckerman, S +5 more
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