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Fas Receptor (CD95)-Mediated Apoptosis in Leukemic Cells
Leukemia and Lymphoma, 1997Binding of Fas ligand (FasL) or an agonistic anti-Fas receptor (Fas/CD95) antibody induces apoptosis in Fas-bearing target cells. The involvement of Fas/FasL pathway has been investigated in human acute myelogenous leukemia (AML) cells. Fas/CD95 is expressed on a majority of AML cells, although the intensity of expression is variable. The cross-linking
Y, Komada, M, Sakurai
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Inhibition of Fas Receptor Endocytosis Sensitizes Cancer Cells to Fas-induced Apoptosis
European Journal of Cancer, 2022Abstract Fas (CD95/APO-1) is a transmembrane death receptor that transduces apoptotic signals upon binding to its ligand and assembling into a death-inducing signaling complex (DISC) ( 1, 2 ).
C. Kural, M. Kural, L. Niklason
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Fas ligand: receptor or ligand?
Apoptosis, 1999In this review, we chronicle the discovery, biochemical characterization, and assignment of Fas (CD95) as receptor and Fas Ligand (FasL, CD95L) as ligand. We review the functional descriptions of the molecules as death-inducing receptor and ligand or as mediators of cell division and/or growth arrest.
M K, Newell, J, Desbarats
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Fas receptor expression on B‐lineage cells
European Journal of Immunology, 1995AbstractMice homozygous for the lpr mutation have B and T cell defects and develop autoantibodies, suggesting that lpr plays a role in their genesis. The lpr defect has been identified as a mutation in the apoptosis‐associated Fas receptor (FasR) gene.
L, Mandik, K A, Nguyen, J, Erikson
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Fas receptor‐mediated apoptosis: a clinical application?
The Journal of Pathology, 2001AbstractFas is a membrane protein belonging to the death receptor family. Cross‐linking of Fas by its ligand, FasL, or agonistic anti‐Fas antibodies, induces apoptosis of cells expressing Fas on the membrane by triggering a cascade of caspases. Since many different tumours express Fas on their membrane, targeting Fas‐mediated apoptosis by anti‐Fas ...
Tineke, Timmer +2 more
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Soluble Fas receptor and soluble Fas ligand in the serum of women with uterine tumors
Apoptosis, 2005It is commonly accepted that apoptosis plays an important role in the death of normal and neoplastic cells. Related proteins and their receptors on cell surfaces regulate apoptosis. One of the best-characterized systems is the Fas-Fas ligand system. The aim of the study was to examine the concentrations of soluble Fas receptor (sFas) and the soluble ...
Z, Kondera-Anasz +2 more
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Apoptosis regulated by a death factor and its receptor: Fas ligand and Fas
Philosophical Transactions of the Royal Society of London. Series B: Biological Sciences, 1994Abstract Homeostasis in vertebrates is tightly regulated by not only proliferation and differentiation of cells, but also cell death or apoptosis (Ellis et al. 1991; Raff 1992). Many cytokines bind to their respective receptors to regulate proliferation and differentiation of cells.
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Fas and Fas Ligand: A Death Factor and Its Receptor
1994Publisher Summary This chapter discusses the Fas /Fas ligand system and its physiological role. The chapter discusses the identification of a natural Fas ligand in a cytotoxic T-lymphocyte (CTL) cell line and proves that it is a member of the tumor necrosis factor (TNF) family.
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Induction of Fas receptor and Fas ligand by nodularin is mediated by NF-κB in HepG2 cells
Toxicology and Applied Pharmacology, 2011Nodularin is a natural toxin with multiple features, including inhibitor of protein phosphatases 1 and 2A as well as tumor initiator and promoter. One unique feature of nodularin is that this chemical is a hepatotoxin. It can accumulate into the liver after contact and lead to severe damage to hepatocyte, such as apoptosis.
Gong, Feng, Ying, Li, Yansheng, Bai
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Death receptors, Fas and TRAIL receptors, are involved in human osteoclast apoptosis
Biochemical and Biophysical Research Communications, 2005Survival and apoptosis are crucial aspects of the osteoclast life cycle. Although osteoclast survival has been extensively studied, little is known about the mechanisms involved in human osteoclast apoptosis. In the present study, cord blood monocytes (CBMs) were used as the source of human osteoclast precursors.
Sophie, Roux +5 more
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