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Fas Receptor (CD95)-Mediated Apoptosis in Leukemic Cells
Leukemia and Lymphoma, 1997Binding of Fas ligand (FasL) or an agonistic anti-Fas receptor (Fas/CD95) antibody induces apoptosis in Fas-bearing target cells. The involvement of Fas/FasL pathway has been investigated in human acute myelogenous leukemia (AML) cells. Fas/CD95 is expressed on a majority of AML cells, although the intensity of expression is variable. The cross-linking
Y Komada
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Fas and Fas Ligand: A Death Factor and Its Receptor
1994Publisher Summary This chapter discusses the Fas /Fas ligand system and its physiological role. The chapter discusses the identification of a natural Fas ligand in a cytotoxic T-lymphocyte (CTL) cell line and proves that it is a member of the tumor necrosis factor (TNF) family.
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Death receptors, Fas and TRAIL receptors, are involved in human osteoclast apoptosis
Biochemical and Biophysical Research Communications, 2005Survival and apoptosis are crucial aspects of the osteoclast life cycle. Although osteoclast survival has been extensively studied, little is known about the mechanisms involved in human osteoclast apoptosis. In the present study, cord blood monocytes (CBMs) were used as the source of human osteoclast precursors.
Sophie, Roux +5 more
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Induction of Fas receptor and Fas ligand by nodularin is mediated by NF-κB in HepG2 cells
Toxicology and Applied Pharmacology, 2011Nodularin is a natural toxin with multiple features, including inhibitor of protein phosphatases 1 and 2A as well as tumor initiator and promoter. One unique feature of nodularin is that this chemical is a hepatotoxin. It can accumulate into the liver after contact and lead to severe damage to hepatocyte, such as apoptosis.
Gong, Feng, Ying, Li, Yansheng, Bai
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In Vivo Inhibition of Fas Ligand-Mediated Killing by TR6, a Fas Ligand Decoy Receptor
The Journal of Pharmacology and Experimental Therapeutics, 2001TR6, a member of the tumor necrosis factor (TNF) receptor superfamily, has recently been shown to bind to Fas ligand (FasL) and inhibit FasL-mediated cell killing in vitro. In the current study, we demonstrate that TR6 can block the lethal activity of FasL in multiple in vitro systems, and extend this finding to an in vivo model of hepatitis.
K, Connolly +16 more
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The Protein Journal, 2016
The Fas receptor is a representative death receptor, and the Fas-associated protein with death domain (FADD) is a crucial adapter protein needed to support the Fas receptor's activity. The Fas-FADD interactions constitute an important signaling pathway that ultimately induces apoptosis or programmed cell death in biological systems.
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The Fas receptor is a representative death receptor, and the Fas-associated protein with death domain (FADD) is a crucial adapter protein needed to support the Fas receptor's activity. The Fas-FADD interactions constitute an important signaling pathway that ultimately induces apoptosis or programmed cell death in biological systems.
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Prognostic significance of the Fas-receptor/Fas-ligand system in cervical squamous cell carcinoma
Virchows Archiv, 2007We studied whether Fas-receptor (Fas-R; CD95) expression, single-nucleotide polymorphisms (SNPs) in the Fas promoter region, and/or Fas-ligand (Fas-L) production could determine individual susceptibility to cervical cancer progression. The clinicopathologic features of 38 patients with cervical squamous carcinomas (22 stage I, 8 stage II, and 8 stage ...
Enrique, Lerma +8 more
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Phosphorylation-Based Signaling in Fas Receptor-Mediated Apoptosis
Critical Reviews™ in Immunology, 2000Apoptosis or programmed cell death plays an essential role during development of the immune system, in immune responses, and in the control of tissue homeostasis in the adult. An important physiological mediator of apoptosis is the Fas/APO-1/CD95 receptor (FasR), a surface receptor belonging to the tumor necrosis factor receptor family.
T H, Holmström, J E, Eriksson
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Fas receptor-mediated apoptosis
The Journal of Pathology, 2002Fas is a membrane protein belonging to the death receptor family. Cross-linking of Fas by its ligand, FasL, or agonistic anti-Fas antibodies, induces apoptosis of cells expressing Fas on the membrane by triggering a cascade of caspases. Since many different tumours express Fas on their membrane, targeting Fas-mediated apoptosis by anti-Fas antibodies ...
Timmer, T, de Vries, EGE, de Jong, S
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Defining the dynamics of self-assembled Fas-receptor activation
Trends in Immunology, 2002Fas-Fas-ligand, the most well investigated apoptotic signaling system, plays a pivotal role in several human diseases. Its signaling through multiple pathways; multiple, complex regulatory points; and recently described tendency to undergo ligand-independent self-assembly warrant a comprehensive understanding of its physiologically well controlled ...
Suneel D, Mundle, Azra, Raza
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